Phospho-JunB (Ser259) Antibody - #AF7242
| 製品: | Phospho-JunB (Ser259) Antibody |
| カタログ: | AF7242 |
| タンパク質の説明: | Rabbit polyclonal antibody to Phospho-JunB (Ser259) |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Dog, Xenopus |
| 分子量: | 40kDa; 36kD(Calculated). |
| ユニプロット: | P17275 |
| RRID: | AB_2843682 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF7242, RRID:AB_2843682.
折りたたみ／展開
Activator protein 1; AP 1; AP1; Jun B; Jun B proto oncogene; Jun B protooncogene; Junb; JunB proto oncogene; JunB protoncogene 9; JunB protooncogene; JUNB_HUMAN; Transcription factor jun B; Transcription factor jun-B; Transcription factor junB;
免疫原
- P17275 JUNB_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MCTKMEQPFYHDDSYTATGYGRAPGGLSLHDYKLLKPSLAVNLADPYRSLKAPGARGPGPEGGGGGSYFSGQGSDTGASLKLASSELERLIVPNSNGVITTTPTPPGQYFYPRGGGSGGGAGGAGGGVTEEQEGFADGFVKALDDLHKMNHVTPPNVSLGATGGPPAGPGGVYAGPEPPPVYTNLSSYSPASASSGGAGAAVGTGSSYPTTTISYLPHAPPFAGGHPAQLGLGRGASTFKEEPQTVPEARSRDATPPVSPINMEDQERIKVERKRLRNRLAATKCRKRKLERIARLEDKVKTLKAENAGLSSTAGLLREQVAQLKQKVMTHVSNGCQLLLGVKGHAF
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P17275 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K4 | Sumoylation | Uniprot | |
| K33 | Sumoylation | Uniprot | |
| K36 | Acetylation | Uniprot | |
| K36 | Sumoylation | Uniprot | |
| K36 | Ubiquitination | Uniprot | |
| Y47 | Phosphorylation | Uniprot | |
| S49 | Phosphorylation | Uniprot | |
| K51 | Sumoylation | Uniprot | |
| Y68 | Phosphorylation | Uniprot | |
| S79 | Phosphorylation | Q16539 (MAPK14) | Uniprot |
| T102 | Phosphorylation | Q16539 (MAPK14) , P45983 (MAPK8) | Uniprot |
| T104 | Phosphorylation | Q16539 (MAPK14) , P45983 (MAPK8) | Uniprot |
| Y109 | Phosphorylation | Uniprot | |
| Y111 | Phosphorylation | Uniprot | |
| S117 | Phosphorylation | Uniprot | |
| T129 | Phosphorylation | Uniprot | |
| T153 | Phosphorylation | Uniprot | |
| Y173 | Phosphorylation | P00519 (ABL1) | Uniprot |
| Y182 | Phosphorylation | P00519 (ABL1) | Uniprot |
| Y188 | Phosphorylation | P00519 (ABL1) | Uniprot |
| S189 | Phosphorylation | Uniprot | |
| S237 | Phosphorylation | Uniprot | |
| T238 | Phosphorylation | Uniprot | |
| K240 | Acetylation | Uniprot | |
| K240 | Sumoylation | Uniprot | |
| K240 | Ubiquitination | Uniprot | |
| S251 | Phosphorylation | P49841 (GSK3B) | Uniprot |
| T255 | Phosphorylation | P49841 (GSK3B) | Uniprot |
| S259 | Phosphorylation | Uniprot | |
| K304 | Sumoylation | Uniprot | |
| K304 | Ubiquitination | Uniprot | |
| S311 | Phosphorylation | Uniprot | |
| S312 | Phosphorylation | Uniprot | |
| K325 | Ubiquitination | Uniprot | |
| T330 | Phosphorylation | Uniprot |
研究背景
Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'.
Ubiquitinated by ITCH, leading to its degradation.
Nucleus.
Binds DNA as a homodimer or as a heterodimer with another member of the Jun/Fos family. Interacts with ITCH (via its WW domains).
Belongs to the bZIP family. Jun subfamily.
研究領域
· Environmental Information Processing > Signal transduction > TNF signaling pathway. (View pathway)
· Organismal Systems > Development > Osteoclast differentiation. (View pathway)
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