Phospho-MARCKS (Ser170) Antibody - #AF7290
| 製品: | Phospho-MARCKS (Ser170) Antibody |
| カタログ: | AF7290 |
| タンパク質の説明: | Rabbit polyclonal antibody to Phospho-MARCKS (Ser170) |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Rabbit, Chicken, Xenopus |
| 分子量: | 31kDa; 32kD(Calculated). |
| ユニプロット: | P29966 |
| RRID: | AB_2843730 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF7290, RRID:AB_2843730.
折りたたみ／展開
80 kDa protein; 80K L; 80K L protein; 80K-L protein; 80KL; 81 kDa protein, light chain; light chain; MACS; MARCKS; MARCS; MARCS_HUMAN; MGC52672; myristoylated alanine rich C kinase substrate; Myristoylated alanine rich protein kinase C substrate (MARCKS, 80K L); Myristoylated alanine rich protein kinase C substrate; Myristoylated alanine-rich C-kinase substrate; Phosphomyristin; PKCSL; PRKCSL; protein kinase C substrate 80 kDa protein light chain; Protein kinase C substrate;
免疫原
- P29966 MARCS_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGAQFSKTAAKGEAAAERPGEAAVASSPSKANGQENGHVKVNGDASPAAAESGAKEELQANGSAPAADKEEPAAAGSGAASPSAAEKGEPAAAAAPEAGASPVEKEAPAEGEAAEPGSPTAAEGEAASAASSTSSPKAEDGATPSPSNETPKKKKKRFSFKKSFKLSGFSFKKNKKEAGEGGEAEAPAAEGGKDEAAGGAAAAAAEAGAASGEQAAAPGEEAAAGEEGAAGGDPQEAKPQEAAVAPEKPPASDETKAAEEPSKVEEKKAEEAGASAAACEAPSAAGPGAPPEQEAAPAEEPAAAAASSACAAPSQEAQPECSPEAPPAEAAE
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P29966 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| G2 | Myristoylation | Uniprot | |
| K11 | Ubiquitination | Uniprot | |
| S26 | Phosphorylation | P24941 (CDK2) | Uniprot |
| S27 | Phosphorylation | P24941 (CDK2) , P17252 (PRKCA) | Uniprot |
| S29 | Phosphorylation | Uniprot | |
| K30 | Ubiquitination | Uniprot | |
| S46 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| S52 | Phosphorylation | Uniprot | |
| K55 | Ubiquitination | Uniprot | |
| S63 | Phosphorylation | Uniprot | |
| K69 | Ubiquitination | Uniprot | |
| S77 | Phosphorylation | Uniprot | |
| S81 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| S83 | Phosphorylation | Uniprot | |
| K87 | Ubiquitination | Uniprot | |
| S101 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| K105 | Ubiquitination | Uniprot | |
| S118 | Phosphorylation | P17252 (PRKCA) , P24941 (CDK2) | Uniprot |
| T120 | Phosphorylation | Uniprot | |
| S128 | Phosphorylation | Uniprot | |
| S131 | Phosphorylation | P24941 (CDK2) | Uniprot |
| S132 | Phosphorylation | P24941 (CDK2) | Uniprot |
| T133 | Phosphorylation | P24941 (CDK2) | Uniprot |
| S134 | Phosphorylation | P24941 (CDK2) | Uniprot |
| S135 | Phosphorylation | P24941 (CDK2) | Uniprot |
| T143 | Phosphorylation | Uniprot | |
| S145 | Phosphorylation | Uniprot | |
| S147 | Phosphorylation | P24941 (CDK2) | Uniprot |
| T150 | Phosphorylation | P24941 (CDK2) | Uniprot |
| K152 | Ubiquitination | Uniprot | |
| K153 | Ubiquitination | Uniprot | |
| S159 | Phosphorylation | Q13464 (ROCK1) , P17252 (PRKCA) , P05771 (PRKCB) , P17612 (PRKACA) , Q16512 (PKN1) | Uniprot |
| K161 | Methylation | Uniprot | |
| S163 | Phosphorylation | P17252 (PRKCA) , Q16512 (PKN1) , P05771 (PRKCB) | Uniprot |
| K165 | Ubiquitination | Uniprot | |
| S167 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| S170 | Phosphorylation | P17252 (PRKCA) , Q16512 (PKN1) , P05771 (PRKCB) | Uniprot |
| K172 | Acetylation | Uniprot | |
| K172 | Methylation | Uniprot | |
| K176 | Ubiquitination | Uniprot | |
| K248 | Methylation | Uniprot | |
| S252 | Phosphorylation | Uniprot | |
| S262 | Phosphorylation | Uniprot | |
| K267 | Ubiquitination | Uniprot | |
| S314 | Phosphorylation | Uniprot |
研究背景
MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.
Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity.
Cytoplasm>Cytoskeleton. Membrane>Lipid-anchor.
Belongs to the MARCKS family.
研究領域
· Human Diseases > Cancers: Overview > MicroRNAs in cancer.
· Organismal Systems > Immune system > Fc gamma R-mediated phagocytosis. (View pathway)
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.