PLD2 Antibody - #AF7603
| 製品: | PLD2 Antibody |
| カタログ: | AF7603 |
| タンパク質の説明: | Rabbit polyclonal antibody to PLD2 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Bovine, Horse, Sheep, Dog, Xenopus |
| 分子量: | 106kDa; 106kD(Calculated). |
| ユニプロット: | O14939 |
| RRID: | AB_2843967 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF7603, RRID:AB_2843967.
折りたたみ／展開
Choline phosphatase 2; EC 3.1.4.4; hPLD 2; hPLD2; mPLD2; Phosphatidylcholine hydrolyzing phospholipase D2; Phosphatidylcholine-hydrolyzing phospholipase D2; Phospholipase D2; PhospholipaseD2; PLD 2; PLD1C; Pld2; PLD2_HUMAN; Pldc; rPLD2;
免疫原
- O14939 PLD2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTATPESLFPTGDELDSSQLQMESDEVDTLKEGEDPADRMHPFLAIYELQSLKVHPLVFAPGVPVTAQVVGTERYTSGSKVGTCTLYSVRLTHGDFSWTTKKKYRHFQELHRDLLRHKVLMSLLPLARFAVAYSPARDAGNREMPSLPRAGPEGSTRHAASKQKYLENYLNRLLTMSFYRNYHAMTEFLEVSQLSFIPDLGRKGLEGMIRKRSGGHRVPGLTCCGRDQVCYRWSKRWLVVKDSFLLYMCLETGAISFVQLFDPGFEVQVGKRSTEARHGVRIDTSHRSLILKCSSYRQARWWAQEITELAQGPGRDFLQLHRHDSYAPPRPGTLARWFVNGAGYFAAVADAILRAQEEIFITDWWLSPEVYLKRPAHSDDWRLDIMLKRKAEEGVRVSILLFKEVELALGINSGYSKRALMLLHPNIKVMRHPDQVTLWAHHEKLLVVDQVVAFLGGLDLAYGRWDDLHYRLTDLGDSSESAASQPPTPRPDSPATPDLSHNQFFWLGKDYSNLITKDWVQLDRPFEDFIDRETTPRMPWRDVGVVVHGLPARDLARHFIQRWNFTKTTKAKYKTPTYPYLLPKSTSTANQLPFTLPGGQCTTVQVLRSVDRWSAGTLENSILNAYLHTIRESQHFLYIENQFFISCSDGRTVLNKVGDEIVDRILKAHKQGWCYRVYVLLPLLPGFEGDISTGGGNSIQAILHFTYRTLCRGEYSILHRLKAAMGTAWRDYISICGLRTHGELGGHPVSELIYIHSKVLIADDRTVIIGSANINDRSLLGKRDSELAVLIEDTETEPSLMNGAEYQAGRFALSLRKHCFGVILGANTRPDLDLRDPICDDFFQLWQDMAESNANIYEQIFRCLPSNATRSLRTLREYVAVEPLATVSPPLARSELTQVQGHLVHFPLKFLEDESLLPPLGSKEGMIPLEVWT
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O14939 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T29 | Phosphorylation | Uniprot | |
| T72 | Phosphorylation | Uniprot | |
| S77 | Phosphorylation | Uniprot | |
| S79 | Phosphorylation | Uniprot | |
| K80 | Ubiquitination | Uniprot | |
| T99 | Phosphorylation | Uniprot | |
| T100 | Phosphorylation | Uniprot | |
| K118 | Ubiquitination | Uniprot | |
| S134 | Phosphorylation | Q00535 (CDK5) | Uniprot |
| S146 | Phosphorylation | Uniprot | |
| T156 | Phosphorylation | Uniprot | |
| S161 | Phosphorylation | Uniprot | |
| Y169 | Phosphorylation | Uniprot | |
| T175 | Phosphorylation | Uniprot | |
| Y179 | Phosphorylation | P00533 (EGFR) | Uniprot |
| S213 | Phosphorylation | Uniprot | |
| S243 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| T252 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| K292 | Methylation | Uniprot | |
| Y296 | Phosphorylation | P00533 (EGFR) | Uniprot |
| K388 | Methylation | Uniprot | |
| K388 | Ubiquitination | Uniprot | |
| Y415 | Phosphorylation | P52333 (JAK3) | Uniprot |
| S416 | Phosphorylation | Uniprot | |
| T488 | Phosphorylation | Uniprot | |
| Y511 | Phosphorylation | P12931 (SRC) | Uniprot |
| T566 | Phosphorylation | Q05655 (PRKCD) | Uniprot |
| Y573 | Phosphorylation | Uniprot | |
| Y578 | Phosphorylation | Uniprot | |
| Y580 | Phosphorylation | Uniprot | |
| K656 | Ubiquitination | Uniprot |
研究背景
May have a role in signal-induced cytoskeletal regulation and/or endocytosis.
Phosphorylated by FGR.
Membrane>Peripheral membrane protein.
Ubiquitous.
Interacts with EGFR (By similarity). Interacts with PIP5K1B.
Belongs to the phospholipase D family.
研究領域
· Cellular Processes > Transport and catabolism > Endocytosis. (View pathway)
· Environmental Information Processing > Signal transduction > Ras signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > cAMP signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Sphingolipid signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Phospholipase D signaling pathway. (View pathway)
· Human Diseases > Cancers: Overview > Choline metabolism in cancer. (View pathway)
· Metabolism > Lipid metabolism > Glycerophospholipid metabolism.
· Metabolism > Lipid metabolism > Ether lipid metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Organismal Systems > Immune system > Fc gamma R-mediated phagocytosis. (View pathway)
· Organismal Systems > Nervous system > Glutamatergic synapse.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.