Glycogen Synthase Antibody - #AF7725
| 製品: | Glycogen Synthase Antibody |
| カタログ: | AF7725 |
| タンパク質の説明: | Rabbit polyclonal antibody to Glycogen Synthase |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Zebrafish, Bovine, Sheep, Rabbit, Dog |
| 分子量: | 85kDa; 84kD(Calculated). |
| ユニプロット: | P13807 |
| RRID: | AB_2844089 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF7725, RRID:AB_2844089.
折りたたみ／展開
Glycogen [starch] synthase; Glycogen synthase 1 (muscle); Glycogen synthase 1; GSY; GYS; Gys1; GYS1_HUMAN; muscle;
免疫原
- P13807 GYS1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P13807 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Phosphorylation | Uniprot | ||
| T6 | Phosphorylation | Uniprot | |
| S8 | Phosphorylation | Uniprot | |
| S10 | Phosphorylation | Uniprot | |
| S11 | Phosphorylation | Uniprot | |
| Y44 | Phosphorylation | Uniprot | |
| K52 | Ubiquitination | Uniprot | |
| T75 | Phosphorylation | Uniprot | |
| K88 | Acetylation | Uniprot | |
| K88 | Ubiquitination | Uniprot | |
| K97 | Acetylation | Uniprot | |
| K97 | Ubiquitination | Uniprot | |
| K100 | Acetylation | Uniprot | |
| Y102 | Phosphorylation | Uniprot | |
| K231 | Ubiquitination | Uniprot | |
| K271 | Ubiquitination | Uniprot | |
| K273 | Ubiquitination | Uniprot | |
| K285 | Ubiquitination | Uniprot | |
| K286 | Ubiquitination | Uniprot | |
| K301 | Ubiquitination | Uniprot | |
| K381 | Ubiquitination | Uniprot | |
| K387 | Ubiquitination | Uniprot | |
| K397 | Ubiquitination | Uniprot | |
| K403 | Ubiquitination | Uniprot | |
| Y405 | Phosphorylation | Uniprot | |
| S412 | Phosphorylation | Uniprot | |
| K418 | Ubiquitination | Uniprot | |
| K422 | Ubiquitination | Uniprot | |
| T426 | Phosphorylation | Uniprot | |
| K429 | Ubiquitination | Uniprot | |
| S484 | Phosphorylation | Uniprot | |
| T485 | Phosphorylation | Uniprot | |
| S486 | Phosphorylation | Uniprot | |
| K599 | Ubiquitination | Uniprot | |
| Y604 | Phosphorylation | Uniprot | |
| K615 | Ubiquitination | Uniprot | |
| Y636 | Phosphorylation | Uniprot | |
| S641 | Phosphorylation | Q96RG2 (PASK) , P49841 (GSK3B) , P49840 (GSK3A) , Q92630 (DYRK2) | Uniprot |
| S645 | Phosphorylation | Q15759 (MAPK11) , P49841 (GSK3B) | Uniprot |
| S647 | Phosphorylation | Uniprot | |
| S649 | Phosphorylation | Uniprot | |
| S652 | Phosphorylation | Uniprot | |
| S653 | Phosphorylation | P49841 (GSK3B) , Q15759 (MAPK11) | Uniprot |
| S657 | Phosphorylation | Uniprot | |
| Y675 | Phosphorylation | Uniprot | |
| K683 | Ubiquitination | Uniprot | |
| S698 | Phosphorylation | Uniprot | |
| T700 | Phosphorylation | Uniprot | |
| S710 | Phosphorylation | Uniprot | |
| T713 | Phosphorylation | Uniprot | |
| T715 | Phosphorylation | Uniprot | |
| S716 | Phosphorylation | Uniprot | |
| S717 | Phosphorylation | Uniprot | |
| S718 | Phosphorylation | Uniprot | |
| T721 | Phosphorylation | Q15759 (MAPK11) | Uniprot |
| S723 | Phosphorylation | Uniprot | |
| S727 | Phosphorylation | Q15759 (MAPK11) | Uniprot |
| T729 | Phosphorylation | Uniprot | |
| S730 | Phosphorylation | Uniprot | |
| S731 | Phosphorylation | Uniprot |
研究背景
Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.
Phosphorylation at Ser-8 by AMPK inactivates the enzyme activity. Primed phosphorylation at Ser-657 (site 5) by CSNK2A1 and CSNK2A2 is required for inhibitory phosphorylation at Ser-641 (site 3a), Ser-645 (site 3b), Ser-649 (site 3c) and Ser-653 (site 4) by GSK3A an GSK3B (By similarity). Phosphorylated at Ser-641 by DYRK2, leading to inactivation (By similarity). Phosphorylated at Ser-641 by PASK, leading to inactivation; phosphorylation by PASK is inhibited by glycogen. Dephosphorylation at Ser-641 and Ser-645 by PP1 activates the enzyme.
Interacts with GYG1.
Belongs to the glycosyltransferase 3 family.
研究領域
· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > AMPK signaling pathway. (View pathway)
· Human Diseases > Endocrine and metabolic diseases > Insulin resistance.
· Metabolism > Carbohydrate metabolism > Starch and sucrose metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Organismal Systems > Endocrine system > Insulin signaling pathway. (View pathway)
· Organismal Systems > Endocrine system > Glucagon signaling pathway.
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