TYK2 Antibody - #AF7788
| 製品: | TYK2 Antibody |
| カタログ: | AF7788 |
| タンパク質の説明: | Rabbit polyclonal antibody to TYK2 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse |
| 予測: | Pig, Bovine, Horse, Sheep, Dog, Xenopus |
| 分子量: | 140kDa; 134kD(Calculated). |
| ユニプロット: | P29597 |
| RRID: | AB_2844152 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF7788, RRID:AB_2844152.
折りたたみ／展開
JTK 1; JTK1; Non receptor tyrosine protein kinase 2; Non receptor tyrosine protein kinase TYK2; Non-receptor tyrosine-protein kinase TYK2; OTTHUMP00000232745; OTTHUMP00000232746; OTTHUMP00000232748; Protein Tyrosine Kinase 2; TYK 2; Tyk2; TYK2_HUMAN; Tyrosine kinase 2;
免疫原
Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.
- P29597 TYK2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P29597 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T67 | Phosphorylation | Uniprot | |
| Y292 | Phosphorylation | Uniprot | |
| S339 | Phosphorylation | Uniprot | |
| S340 | Phosphorylation | Uniprot | |
| K354 | Ubiquitination | Uniprot | |
| K389 | Ubiquitination | Uniprot | |
| K401 | Ubiquitination | Uniprot | |
| S406 | Phosphorylation | Uniprot | |
| S415 | Phosphorylation | Uniprot | |
| Y423 | Phosphorylation | Uniprot | |
| Y433 | Phosphorylation | Uniprot | |
| S491 | Phosphorylation | Uniprot | |
| S499 | Phosphorylation | Uniprot | |
| K504 | Ubiquitination | Uniprot | |
| S577 | Phosphorylation | Uniprot | |
| S580 | Phosphorylation | Uniprot | |
| K587 | Ubiquitination | Uniprot | |
| S613 | Phosphorylation | Uniprot | |
| S720 | Phosphorylation | Uniprot | |
| S723 | Phosphorylation | Uniprot | |
| K728 | Ubiquitination | Uniprot | |
| K756 | Ubiquitination | Uniprot | |
| K823 | Ubiquitination | Uniprot | |
| Y827 | Phosphorylation | Uniprot | |
| Y851 | Phosphorylation | Uniprot | |
| S884 | Phosphorylation | Uniprot | |
| K899 | Ubiquitination | Uniprot | |
| K930 | Ubiquitination | Uniprot | |
| K933 | Ubiquitination | Uniprot | |
| K945 | Ubiquitination | Uniprot | |
| K963 | Ubiquitination | Uniprot | |
| K1046 | Ubiquitination | Uniprot | |
| Y1054 | Phosphorylation | P29597 (TYK2) , P23458 (JAK1) | Uniprot |
| Y1055 | Phosphorylation | P29597 (TYK2) , P23458 (JAK1) | Uniprot |
| K1074 | Ubiquitination | Uniprot | |
| K1175 | Ubiquitination | Uniprot |
PTMs - P29597 酵素として
| Substrate | Site | Source |
|---|---|---|
| O15304 (SIVA1) | Y53 | Uniprot |
| O15304 (SIVA1) | Y162 | Uniprot |
| P17181 (IFNAR1) | Y466 | Uniprot |
| P17181 (IFNAR1) | Y481 | Uniprot |
| P29597 (TYK2) | Y1054 | Uniprot |
| P29597 (TYK2) | Y1055 | Uniprot |
| P42224-2 (STAT1) | Y701 | Uniprot |
| P51452 (DUSP3) | Y138 | Uniprot |
| P63244 (RACK1) | Y194 | Uniprot |
| Q13651 (IL10RA) | Y446 | Uniprot |
| Q13651 (IL10RA) | Y496 | Uniprot |
| Q9BZL6 (PRKD2) | Y438 | Uniprot |
研究背景
Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.
Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.
Interacts with JAKMIP1.
The FERM domain mediates interaction with JAKMIP1.
Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
研究領域
· Cellular Processes > Cell growth and death > Necroptosis. (View pathway)
· Environmental Information Processing > Signal transduction > Jak-STAT signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Parasitic > Toxoplasmosis.
· Human Diseases > Infectious diseases: Viral > Hepatitis C.
· Human Diseases > Infectious diseases: Viral > Measles.
· Human Diseases > Infectious diseases: Viral > Influenza A.
· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.
· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.
· Human Diseases > Infectious diseases: Viral > Epstein-Barr virus infection.
· Organismal Systems > Development > Osteoclast differentiation. (View pathway)
· Organismal Systems > Immune system > NOD-like receptor signaling pathway. (View pathway)
· Organismal Systems > Immune system > Th1 and Th2 cell differentiation. (View pathway)
· Organismal Systems > Immune system > Th17 cell differentiation. (View pathway)
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.