A-RAF Antibody - #DF10327
製品: | A-RAF Antibody |
カタログ: | DF10327 |
タンパク質の説明: | Rabbit polyclonal antibody to A-RAF |
アプリケーション: | WB |
反応性: | Human, Mouse, Rat, Monkey |
予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus |
分子量: | 68kDa; 68kD(Calculated). |
ユニプロット: | P10398 |
RRID: | AB_2844334 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF10327, RRID:AB_2844334.
折りたたみ/展開
A raf 1; A Raf proto oncogene serine/threonine protein kinase; ARAF 1; Araf; ARaf proto oncogene serine/threonine protein kinase; ARAF_HUMAN; ARAF1; Oncogene Araf1; Oncogene PKS2; PKS 2; PKS; PKS2; Proto oncogene Pks; Proto-oncogene A-Raf; Proto-oncogene A-Raf-1; Proto-oncogene Pks; RAFA 1; RAFA1; Ras binding protein DA Raf; Serine/threonine-protein kinase A-Raf; v raf murine sarcoma 3611 viral oncogene homolog; v raf murine sarcoma 3611 viral oncogene homolog 1; v raf oncogene homolog 1 (murine sarcoma 3611 virus);
免疫原
- P10398 ARAF_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCVVYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPSNRPLNELLTPQGPSPRTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFSTDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P10398 基板として
Site | PTM Type | Enzyme | Source |
---|---|---|---|
S15 | Phosphorylation | Uniprot | |
T20 | Phosphorylation | Uniprot | |
Y24 | Phosphorylation | Uniprot | |
K28 | Ubiquitination | Uniprot | |
Y42 | Phosphorylation | Uniprot | |
Y155 | Phosphorylation | Uniprot | |
S157 | Phosphorylation | Uniprot | |
S162 | Phosphorylation | Uniprot | |
T181 | Phosphorylation | Uniprot | |
S186 | Phosphorylation | Uniprot | |
S212 | Phosphorylation | Uniprot | |
T213 | Phosphorylation | Uniprot | |
S214 | Phosphorylation | Uniprot | |
T215 | Phosphorylation | Uniprot | |
S222 | Phosphorylation | Uniprot | |
T223 | Phosphorylation | Uniprot | |
T224 | Phosphorylation | Uniprot | |
S229 | Phosphorylation | Uniprot | |
S250 | Phosphorylation | Uniprot | |
T253 | Phosphorylation | Uniprot | |
S257 | Phosphorylation | Uniprot | |
S259 | Phosphorylation | Uniprot | |
S262 | Phosphorylation | Uniprot | |
S264 | Phosphorylation | Uniprot | |
S265 | Phosphorylation | Uniprot | |
S269 | Phosphorylation | Uniprot | |
S272 | Phosphorylation | Uniprot | |
S274 | Phosphorylation | Uniprot | |
K282 | Ubiquitination | Uniprot | |
S283 | Phosphorylation | Uniprot | |
K292 | Ubiquitination | Uniprot | |
Y296 | Phosphorylation | Uniprot | |
S299 | Phosphorylation | Q13153 (PAK1) | Uniprot |
Y301 | Phosphorylation | P12931 (SRC) | Uniprot |
Y302 | Phosphorylation | P12931 (SRC) | Uniprot |
K314 | Ubiquitination | Uniprot | |
T318 | Phosphorylation | Uniprot | |
S320 | Phosphorylation | Uniprot | |
T323 | Phosphorylation | Uniprot | |
K339 | Ubiquitination | Uniprot | |
S341 | Phosphorylation | Uniprot | |
T344 | Phosphorylation | Uniprot | |
K352 | Ubiquitination | Uniprot | |
T413 | Phosphorylation | Uniprot | |
Y419 | Phosphorylation | Uniprot | |
K423 | Ubiquitination | Uniprot | |
K431 | Ubiquitination | Uniprot | |
S432 | Phosphorylation | Uniprot | |
T442 | Phosphorylation | Uniprot | |
T452 | Phosphorylation | Uniprot | |
K454 | Ubiquitination | Uniprot | |
T455 | Phosphorylation | Uniprot | |
S458 | Phosphorylation | Uniprot | |
Y526 | Phosphorylation | Uniprot | |
S528 | Phosphorylation | Uniprot | |
S532 | Phosphorylation | Uniprot | |
S535 | Phosphorylation | Uniprot | |
S536 | Phosphorylation | Uniprot | |
K540 | Ubiquitination | Uniprot | |
S547 | Phosphorylation | Uniprot | |
K551 | Ubiquitination | Uniprot | |
S573 | Phosphorylation | Uniprot | |
K576 | Ubiquitination | Uniprot | |
S576 | Phosphorylation | Uniprot | |
S580 | Phosphorylation | Uniprot | |
S582 | Phosphorylation | Uniprot | |
S585 | Phosphorylation | Uniprot | |
T589 | Phosphorylation | Uniprot | |
S600 | Phosphorylation | Uniprot |
PTMs - P10398 酵素として
研究背景
Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade.
Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation.
Predominantly in urogenital tissues.
Interacts with TH1L/NELFD.
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.
研究領域
· Cellular Processes > Cell motility > Regulation of actin cytoskeleton. (View pathway)
· Environmental Information Processing > Signal transduction > MAPK signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > ErbB signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > FoxO signaling pathway. (View pathway)
· Human Diseases > Drug resistance: Antineoplastic > EGFR tyrosine kinase inhibitor resistance.
· Human Diseases > Drug resistance: Antineoplastic > Endocrine resistance.
· Human Diseases > Substance dependence > Alcoholism.
· Human Diseases > Infectious diseases: Viral > Hepatitis C.
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Cancers: Overview > Proteoglycans in cancer.
· Human Diseases > Cancers: Specific types > Colorectal cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Renal cell carcinoma. (View pathway)
· Human Diseases > Cancers: Specific types > Pancreatic cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Endometrial cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Glioma. (View pathway)
· Human Diseases > Cancers: Specific types > Prostate cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Melanoma. (View pathway)
· Human Diseases > Cancers: Specific types > Bladder cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Chronic myeloid leukemia. (View pathway)
· Human Diseases > Cancers: Specific types > Acute myeloid leukemia. (View pathway)
· Human Diseases > Cancers: Specific types > Non-small cell lung cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Breast cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Hepatocellular carcinoma. (View pathway)
· Human Diseases > Cancers: Specific types > Gastric cancer. (View pathway)
· Organismal Systems > Circulatory system > Vascular smooth muscle contraction. (View pathway)
· Organismal Systems > Immune system > Natural killer cell mediated cytotoxicity. (View pathway)
· Organismal Systems > Nervous system > Long-term potentiation.
· Organismal Systems > Nervous system > Serotonergic synapse.
· Organismal Systems > Nervous system > Long-term depression.
· Organismal Systems > Endocrine system > Insulin signaling pathway. (View pathway)
· Organismal Systems > Endocrine system > Progesterone-mediated oocyte maturation.
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