Phospho-DEPTOR (Ser244) Antibody - #AF4313

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製品: Phospho-DEPTOR (Ser244) Antibody
カタログ: AF4313
タンパク質の説明: Rabbit polyclonal antibody to Phospho-DEPTOR (Ser244)
アプリケーション: WB
反応性: Human, Mouse, Rat
予測: Zebrafish, Bovine, Horse, Rabbit, Dog, Chicken, Xenopus
分子量: 48kDa; 46kD(Calculated).
ユニプロット: Q8TB45
RRID: AB_2844392

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Zebrafish(90%), Bovine(100%), Horse(100%), Rabbit(91%), Dog(100%), Chicken(80%), Xenopus(82%)
クローナリティ:
Polyclonal
特異性:
Phospho-DEPTOR (Ser244) Antibody detects endogenous levels of DEPTOR only when phosphorylated at Ser244.
RRID:
AB_2844392
引用形式: Affinity Biosciences Cat# AF4313, RRID:AB_2844392.
コンジュゲート:
Unconjugated.
精製:
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

DEP domain containing 6; DEP domain-containing mTOR-interacting protein; DEP domain-containing protein 6; DEP.6; DEPDC6; DEPTOR; DPTOR_HUMAN;

免疫原

免疫原:

A synthesized peptide derived from human DEPTOR around the phosphorylation site of Ser244.

Uniprot:

Q8TB45(DPTOR_HUMAN) >>Visit HPA database.

遺伝子(ID):
DEPTOR(64798)
タンパク質配列:
MEEGGSTGSAGSDSSTSGSGGAQQRELERMAEVLVTGEQLRLRLHEEKVIKDRRHHLKTYPNCFVAKELIDWLIEHKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRFRKDDGTFPLDNEVKAFMRGQRLYEKLMSPENTLLQPREEEGVKYERTFMASEFLDWLVQEGEATTRKEAEQLCHRLMEHGIIQHVSNKHPFVDSNLLYQFRMNFRRRRRLMELLNEKSPSSQETHDSPFCLRKQSHDNRKSTSFMSVSPSKEIKIVSAVRRSSMSSCGSSGYFSSSPTLSSSPPVLCNPKSVLKRPVTSEELLTPGAPYARKTFTIVGDAVGWGFVVRGSKPCHIQAVDPSGPAAAAGMKVCQFVVSVNGLNVLHVDYRTVSNLILTGPRTIVMEVMEELEC

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Horse
100
Bovine
100
Dog
100
Rabbit
91
Zebrafish
90
Xenopus
82
Chicken
80
Pig
0
Sheep
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

研究背景

機能:

Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes.

PTMs:

Phosphorylated. Phosphorylation weakens interaction with MTOR within mTORC1 and mTORC2.

Ubiquitinated; ubiquitination leads to proteasomal degradation.

研究領域

· Cellular Processes > Transport and catabolism > Autophagy - animal.   (View pathway)

· Environmental Information Processing > Signal transduction > mTOR signaling pathway.   (View pathway)

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