Phospho-GRAP2 (Thr262) Antibody - #AF4322
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF4322, RRID:AB_2844401.
折りたたみ／展開
Adapter protein GRID; GADS; GADS protein; GRAP-2; Grap2; GRAP2_HUMAN; GRB-2-like protein; GRB2-related adapter protein 2; GRB2-related adaptor protein 2; GRB2-related protein with insert domain; GRB2L; GRBLG; GRBX; Grf-40; Grf40 adapter protein; Grf40; GRID; Growth factor receptor-binding protein; Growth factor receptor-bound protein 2-related adaptor protein 2; GRPL; Hema; Hematopoietic cell-associated adapter protein GrpL; Hematopoietic cell-associated adaptor protein GRPL; Mona; p38; Protein GADS; SH3-SH2-SH3 adapter Mona; SH3-SH2-SH3 adaptor molecule;
免疫原
- O75791 GRAP2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEAVAKFDFTASGEDELSFHTGDVLKILSNQEEWFKAELGSQEGYVPKNFIDIQFPKWFHEGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFLWTEKFPSLNKLVDYYRTNSISRQKQIFLRDRTREDQGHRGNSLDRRSQGGPHLSGAVGEEIRPSMNRKLSDHPPTLPLQQHQHQPQPPQYAPAPQQLQQPPQQRYLQHHHFHQERRGGSLDINDGHCGTGLGSEMNAALMHRRHTDPVQLQAAGRVRWARALYDFEALEDDELGFHSGEVVEVLDSSNPSWWTGRLHNKLGLFPANYVAPMTR
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O75791 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K36 | Ubiquitination | Uniprot | |
| S41 | Phosphorylation | Uniprot | |
| Y45 | Phosphorylation | Uniprot | |
| K48 | Ubiquitination | Uniprot | |
| K57 | Ubiquitination | Uniprot | |
| K106 | Acetylation | Uniprot | |
| K112 | Ubiquitination | Uniprot | |
| K121 | Ubiquitination | Uniprot | |
| K127 | Ubiquitination | Uniprot | |
| Y131 | Phosphorylation | Uniprot | |
| K141 | Ubiquitination | Uniprot | |
| S159 | Phosphorylation | Uniprot | |
| S164 | Phosphorylation | Uniprot | |
| S181 | Phosphorylation | Uniprot | |
| S187 | Phosphorylation | Uniprot | |
| T192 | Phosphorylation | Uniprot | |
| Y207 | Phosphorylation | Uniprot | |
| Y222 | Phosphorylation | Uniprot | |
| R233 | Methylation | Uniprot | |
| S236 | Phosphorylation | Uniprot | |
| T246 | Phosphorylation | Uniprot | |
| S250 | Phosphorylation | Uniprot | |
| T262 | Phosphorylation | Uniprot | |
| Y324 | Phosphorylation | Uniprot |
研究背景
Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.
Nucleus. Cytoplasm. Endosome.
Interacts with phosphorylated LIME1 upon TCR activation (By similarity). Interacts with phosphorylated LAT and LAX1 upon TCR activation. Interacts with SHB. Interacts with PTPN23.
Belongs to the GRB2/sem-5/DRK family.
研究領域
· Organismal Systems > Immune system > T cell receptor signaling pathway. (View pathway)
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For Research Use Only.
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