Phospho-MAP2 (Thr1620/Thr1623) Antibody - #AF4402
製品: | Phospho-MAP2 (Thr1620/Thr1623) Antibody |
カタログ: | AF4402 |
タンパク質の説明: | Rabbit polyclonal antibody to Phospho-MAP2 (Thr1620/Thr1623) |
アプリケーション: | WB |
反応性: | Human, Mouse, Rat |
予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
分子量: | 82kDa,280kDa; 200kD(Calculated). |
ユニプロット: | P11137 |
RRID: | AB_2844467 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF4402, RRID:AB_2844467.
折りたたみ/展開
DKFZp686I2148; MAP 2; MAP dendrite specific; MAP-2; MAP2; MAP2A; MAP2B; MAP2C; Microtubule associated protein 2; Microtubule-associated protein 2; MTAP2_HUMAN;
免疫原
- P11137 MTAP2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MADERKDEAKAPHWTSAPLTEASAHSHPPEIKDQGGAGEGLVRSANGFPYREDEEGAFGEHGSQGTYSNTKENGINGELTSADRETAEEVSARIVQVVTAEAVAVLKGEQEKEAQHKDQTAALPLAAEETANLPPSPPPSPASEQTVTVEEDLLTASKMEFHDQQELTPSTAEPSDQKEKESEKQSKPGEDLKHAALVSQPETTKTYPDKKDMQGTEEEKAPLALFGHTLVASLEDMKQKTEPSLVVPGIDLPKEPPTPKEQKDWFIEMPTEAKKDEWGLVAPISPGPLTPMREKDVFDDIPKWEGKQFDSPMPSPFQGGSFTLPLDVMKNEIVTETSPFAPAFLQPDDKKSLQQTSGPATAKDSFKIEEPHEAKPDKMAEAPPSEAMTLPKDAHIPVVEEHVMGKVLEEEKEAINQETVQQRDTFTPSGQEPILTEKETELKLEEKTTISDKEAVPKESKPPKPADEEIGIIQTSTEHTFSEQKDQEPTTDMLKQDSFPVSLEQAVTDSAMTSKTLEKAMTEPSALIEKSSIQELFEMRVDDKDKIEGVGAATSAELDMPFYEDKSGMSKYFETSALKEEATKSIEPGSDYYELSDTRESVHESIDTMSPMHKNGDKEFQTGKESQPSPPAQEAGYSTLAQSYPSDLPEEPSSPQERMFTIDPKVYGEKRDLHSKNKDDLTLSRSLGLGGRSAIEQRSMSINLPMSCLDSIALGFNFGRGHDLSPLASDILTNTSGSMDEGDDYLPATTPALEKAPCFPVESKEEEQIEKVKATGEESTQAEISCESPFLAKDFYKNGTVMAPDLPEMLDLAGTRSRLASVSADAEVARRKSVPSETVVEDSRTGLPPVTDENHVIVKTDSQLEDLGYCVFNKYTVPLPSPVQDSENLSGESGTFYEGTDDKVRRDLATDLSLIEVKLAAAGRVKDEFSVDKEASAHISGDKSGLSKEFDQEKKANDRLDTVLEKSEEHADSKEHAKKTEEAGDEIETFGLGVTYEQALAKDLSIPTDASSEKAEKGLSSVPEIAEVEPSKKVEQGLDFAVQGQLDVKISDFGQMASGLNIDDRRATELKLEATQDMTPSSKAPQEADAFMGVESGHMKEGTKVSETEVKEKVAKPDLVHQEAVDKEESYESSGEHESLTMESLKADEGKKETSPESSLIQDEIAVKLSVEIPCPPAVSEADLATDERADVQMEFIQGPKEESKETPDISITPSDVAEPLHETIVSEPAEIQSEEEEIEAQGEYDKLLFRSDTLQITDLGVSGAREEFVETCPSEHKGVIESVVTIEDDFITVVQTTTDEGESGSHSVRFAALEQPEVERRPSPHDEEEFEVEEAAEAQAEPKDGSPEAPASPEREEVALSEYKTETYDDYKDETTIDDSIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAEKEARRSSLEKHRKEKPFKTGRGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKTEVQAHSPSRKFILKPAIKYTRPTHLSCVKRKTTAAGGESALAPSVFKQAKDKVSDGVTKSPEKRSSLPRPSSILPPRRGVSGDRDENSFSLNSSISSSARRTTRSEPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTPGTPGTPSYPRTPHTPGTPKSAILVPSEKKVAIIRTPPKSPATPKQLRLINQPLPDLKNVKSKIGSTDNIKYQPKGGQVQIVTKKIDLSHVTSKCGSLKNIRHRPGGGRVKIESVKLDFKEKAQAKVGSLDNAHHVPGGGNVKIDSQKLNFREHAKARVDHGAEIITQSPGRSSVASPRRLSNVSSSGSINLLESPQLATLAEDVTAALAKQGL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P11137 基板として
Site | PTM Type | Enzyme | Source |
---|---|---|---|
Y50 | Phosphorylation | Uniprot | |
S63 | Phosphorylation | Uniprot | |
T66 | Phosphorylation | Uniprot | |
Y67 | Phosphorylation | P07948 (LYN) , P06241 (FYN) | Uniprot |
S136 | Phosphorylation | Uniprot | |
T168 | Phosphorylation | Uniprot | |
T216 | Phosphorylation | Uniprot | |
S233 | Phosphorylation | Uniprot | |
T241 | Phosphorylation | Uniprot | |
T258 | Phosphorylation | Uniprot | |
S285 | Phosphorylation | Uniprot | |
T290 | Phosphorylation | Uniprot | |
S311 | Phosphorylation | Uniprot | |
S315 | Phosphorylation | Uniprot | |
S321 | Phosphorylation | Uniprot | |
T323 | Phosphorylation | Uniprot | |
S357 | Phosphorylation | Uniprot | |
T361 | Phosphorylation | Uniprot | |
S385 | Phosphorylation | Q9P0L2 (MARK1) | Uniprot |
T427 | Phosphorylation | Uniprot | |
T516 | Phosphorylation | Uniprot | |
S532 | Phosphorylation | Uniprot | |
S585 | Phosphorylation | Uniprot | |
Y592 | Phosphorylation | Uniprot | |
Y593 | Phosphorylation | Uniprot | |
S610 | Phosphorylation | Uniprot | |
S629 | Phosphorylation | Uniprot | |
S725 | Phosphorylation | Uniprot | |
S785 | Phosphorylation | Uniprot | |
S788 | Phosphorylation | Uniprot | |
S821 | Phosphorylation | Uniprot | |
S823 | Phosphorylation | Uniprot | |
S833 | Phosphorylation | Uniprot | |
S843 | Phosphorylation | Uniprot | |
T860 | Phosphorylation | Uniprot | |
S862 | Phosphorylation | Uniprot | |
S881 | Phosphorylation | Uniprot | |
S913 | Phosphorylation | Uniprot | |
Y996 | Phosphorylation | Uniprot | |
S1005 | Phosphorylation | Uniprot | |
S1021 | Phosphorylation | Uniprot | |
S1031 | Phosphorylation | Uniprot | |
S1106 | Phosphorylation | Uniprot | |
T1108 | Phosphorylation | Uniprot | |
S1139 | Phosphorylation | Uniprot | |
T1154 | Phosphorylation | Uniprot | |
S1155 | Phosphorylation | Uniprot | |
S1158 | Phosphorylation | Uniprot | |
S1234 | Phosphorylation | Uniprot | |
S1324 | Phosphorylation | Uniprot | |
S1347 | Phosphorylation | Uniprot | |
S1353 | Phosphorylation | Uniprot | |
T1366 | Phosphorylation | Uniprot | |
T1368 | Phosphorylation | Uniprot | |
Y1369 | Phosphorylation | Uniprot | |
S1398 | Phosphorylation | Uniprot | |
S1420 | Phosphorylation | Uniprot | |
S1421 | Phosphorylation | Uniprot | |
K1427 | Acetylation | Uniprot | |
T1440 | Phosphorylation | Uniprot | |
K1447 | Ubiquitination | Uniprot | |
K1448 | Ubiquitination | Uniprot | |
S1480 | Phosphorylation | Uniprot | |
Y1493 | Phosphorylation | Uniprot | |
T1494 | Phosphorylation | Uniprot | |
T1497 | Phosphorylation | Uniprot | |
S1500 | Phosphorylation | Uniprot | |
K1505 | Acetylation | Uniprot | |
T1506 | Phosphorylation | Uniprot | |
K1524 | Acetylation | Uniprot | |
S1534 | Phosphorylation | Uniprot | |
S1539 | Phosphorylation | Uniprot | |
S1540 | Phosphorylation | Uniprot | |
S1546 | Phosphorylation | Uniprot | |
S1555 | Phosphorylation | Uniprot | |
S1562 | Phosphorylation | Uniprot | |
S1564 | Phosphorylation | Uniprot | |
S1588 | Phosphorylation | Uniprot | |
T1590 | Phosphorylation | Uniprot | |
S1591 | Phosphorylation | Uniprot | |
T1592 | Phosphorylation | Uniprot | |
T1594 | Phosphorylation | Uniprot | |
T1595 | Phosphorylation | Uniprot | |
S1598 | Phosphorylation | Uniprot | |
T1599 | Phosphorylation | Uniprot | |
T1602 | Phosphorylation | Uniprot | |
T1605 | Phosphorylation | Uniprot | |
S1608 | Phosphorylation | Uniprot | |
Y1609 | Phosphorylation | Uniprot | |
S1611 | Phosphorylation | Uniprot | |
T1613 | Phosphorylation | Uniprot | |
T1616 | Phosphorylation | Uniprot | |
T1619 | Phosphorylation | Uniprot | |
S1621 | Phosphorylation | Uniprot | |
Y1622 | Phosphorylation | Uniprot | |
T1628 | Phosphorylation | Uniprot | |
T1631 | Phosphorylation | Uniprot | |
S1634 | Phosphorylation | Uniprot | |
S1640 | Phosphorylation | Uniprot | |
T1649 | Phosphorylation | Uniprot | |
S1653 | Phosphorylation | Uniprot | |
T1656 | Phosphorylation | Uniprot | |
S1675 | Phosphorylation | Uniprot | |
S1679 | Phosphorylation | P17612 (PRKACA) , Q9P0L2 (MARK1) | Uniprot |
T1680 | Phosphorylation | Uniprot | |
S1702 | Phosphorylation | Uniprot | |
S1706 | Phosphorylation | Uniprot | |
S1710 | Phosphorylation | Q9P0L2 (MARK1) , P17612 (PRKACA) | Uniprot |
S1727 | Phosphorylation | Uniprot | |
S1742 | Phosphorylation | P17612 (PRKACA) | Uniprot |
T1780 | Phosphorylation | Uniprot | |
S1782 | Phosphorylation | P17612 (PRKACA) | Uniprot |
S1786 | Phosphorylation | Uniprot | |
S1787 | Phosphorylation | Uniprot | |
S1790 | Phosphorylation | Uniprot | |
S1795 | Phosphorylation | Uniprot | |
S1798 | Phosphorylation | Uniprot | |
S1799 | Phosphorylation | Uniprot | |
S1800 | Phosphorylation | Uniprot | |
S1802 | Phosphorylation | Uniprot | |
S1808 | Phosphorylation | Uniprot | |
T1813 | Phosphorylation | Uniprot | |
T1819 | Phosphorylation | Uniprot |
研究背景
The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). Isoform 2 is probably phosphorylated by PKA at Ser-323, Ser-354 and Ser-386 and by FYN at Tyr-67. The interaction with KNDC1 enhances MAP2 threonine phosphorylation (By similarity).
Cytoplasm>Cytoskeleton. Cell projection>Dendrite.
Interacts with KNDC1 (via KIND2); the interaction enhances MAP2 phosphorylation and localizes KNDC1 to dendrites.
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