p50 Dynamitin Antibody - #AF0232
| 製品: | p50 Dynamitin Antibody |
| カタログ: | AF0232 |
| タンパク質の説明: | Rabbit polyclonal antibody to p50 Dynamitin |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 50kDa; 44kD(Calculated). |
| ユニプロット: | Q13561 |
| RRID: | AB_2833407 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF0232, RRID:AB_2833407.
折りたたみ／展開
50 kD dynein associated polypeptide; 50 kDa dynein associated polypeptide; 50 kDa dynein-associated polypeptide; DCTN-50; DCTN2; DCTN2_HUMAN; DCTN50; dynactin 2 (p50); dynactin 2; dynactin complex 50 kD subunit; Dynactin complex 50 kDa subunit; Dynactin subunit 2; DYNAMITIN; p50 dynamitin; RBP50;
免疫原
- Q13561 DCTN2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAEELTSTSVEHIIVNPNAAYDKFKDKRVGTKGLDFSDRIGKTKRTGYESGEYEMLGEGLGVKETPQQKYQRLLHEVQELTTEVEKIKTTVKESATEEKLTPVLLAKQLAALKQQLVASHLEKLLGPDAAINLTDPDGALAKRLLLQLEATKNSKGGSGGKTTGTPPDSSLVTYELHSRPEQDKFSQAAKVAELEKRLTELETAVRCDQDAQNPLSAGLQGACLMETVELLQAKVSALDLAVLDQVEARLQSVLGKVNEIAKHKASVEDADTQSKVHQLYETIQRWSPIASTLPELVQRLVTIKQLHEQAMQFGQLLTHLDTTQQMIANSLKDNTTLLTQVQTTMRENLATVEGNFASIDERMKKLGK
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q13561 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| K5 | Ubiquitination | Uniprot | |
| Y6 | Phosphorylation | Uniprot | |
| Y54 | Phosphorylation | Uniprot | |
| K65 | Methylation | Uniprot | |
| K65 | Ubiquitination | Uniprot | |
| S70 | Phosphorylation | Uniprot | |
| R72 | Methylation | Uniprot | |
| Y81 | Phosphorylation | Uniprot | |
| S83 | Phosphorylation | Uniprot | |
| Y86 | Phosphorylation | Uniprot | |
| T98 | Phosphorylation | Uniprot | |
| K102 | Ubiquitination | Uniprot | |
| T115 | Phosphorylation | Uniprot | |
| K119 | Ubiquitination | Uniprot | |
| K125 | Ubiquitination | Uniprot | |
| S127 | Phosphorylation | Uniprot | |
| T134 | Phosphorylation | Uniprot | |
| K140 | Ubiquitination | Uniprot | |
| K146 | Ubiquitination | Uniprot | |
| S152 | Phosphorylation | Uniprot | |
| K156 | Ubiquitination | Uniprot | |
| K175 | Ubiquitination | Uniprot | |
| T198 | Phosphorylation | Uniprot | |
| S202 | Phosphorylation | Uniprot | |
| Y207 | Phosphorylation | Uniprot | |
| K217 | Ubiquitination | Uniprot | |
| K223 | Ubiquitination | Uniprot | |
| T232 | Phosphorylation | Uniprot | |
| S249 | Phosphorylation | Uniprot | |
| T260 | Phosphorylation | Uniprot | |
| S285 | Phosphorylation | Uniprot | |
| K289 | Ubiquitination | Uniprot | |
| K297 | Ubiquitination | Uniprot | |
| K308 | Acetylation | Uniprot | |
| K308 | Ubiquitination | Uniprot | |
| Y313 | Phosphorylation | Uniprot | |
| T315 | Phosphorylation | Uniprot | |
| S320 | Phosphorylation | Uniprot |
研究背景
Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.
Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome. Membrane>Peripheral membrane protein.
Subunit of dynactin, a multiprotein complex associated with dynein. Interacts with BICD2 and CEP135 (By similarity). Interacts with DYNAP. Interacts with ECPAS. Interacts with MAPRE1.
Belongs to the dynactin subunit 2 family.
研究領域
· Human Diseases > Neurodegenerative diseases > Huntington's disease.
· Organismal Systems > Excretory system > Vasopressin-regulated water reabsorption.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.