CD32 Antibody - #AF4648
| 製品: | CD32 Antibody |
| カタログ: | AF4648 |
| タンパク質の説明: | Rabbit polyclonal antibody to CD32 |
| アプリケーション: | WB |
| 反応性: | Human |
| 分子量: | 40,44 kDa; 35kD(Calculated). |
| ユニプロット: | P12318 |
| RRID: | AB_2844590 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF4648, RRID:AB_2844590.
折りたたみ／展開
CD32; CD32 antigen; CDw32; Fc fragment of IgG, low affinity IIa, receptor (CD32); Fc fragment of IgG, low affinity IIa, receptor for (CD32); Fc gamma RII a; Fc gamma RIIa; Fc-gamma RII-a; Fc-gamma-RIIa; FCG2; FCG2A_HUMAN; FcGR; FCGR2; FCGR2A; FCGR2A1; FcRII a; FcRII-a; IGFR2; IgG Fc receptor II a; IgG Fc receptor II-a; Immunoglobulin G Fc receptor II; low affinity immunoglobulin gamma Fc region receptor II a; Low affinity immunoglobulin gamma Fc region receptor II-a;
免疫原
- P12318 FCG2A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTMETQMSQNVCPRNLWLLQPLTVLLLLASADSQAAAPPKAVLKLEPPWINVLQEDSVTLTCQGARSPESDSIQWFHNGNLIPTHTQPSYRFKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEGETIMLRCHSWKDKPLVKVTFFQNGKSQKFSHLDPTFSIPQANHSHSGDYHCTGNIGYTLFSSKPVTITVQVPSMGSSSPMGIIVAVVIATAVAAIVAAVVALIYCRKKRISANSTDPVKAAQFEPPGRQMIAIRKRQLEETNNDYETADGGYMTLNPRAPTDDDKNIYLTLPPNDHVNSNN
PTMs - P12318 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N97 | N-Glycosylation | Uniprot | |
| N178 | N-Glycosylation | Uniprot | |
| Y240 | Phosphorylation | Uniprot | |
| K255 | Ubiquitination | Uniprot | |
| K271 | Acetylation | Uniprot | |
| T277 | Phosphorylation | Uniprot | |
| Y281 | Phosphorylation | P51451 (BLK) , P43405 (SYK) , P07948 (LYN) , P06241 (FYN) | Uniprot |
| T283 | Phosphorylation | Uniprot | |
| Y288 | Phosphorylation | P07948 (LYN) , P43405 (SYK) , P51451 (BLK) , P06241 (FYN) | Uniprot |
| T290 | Phosphorylation | Uniprot | |
| T297 | Phosphorylation | Uniprot | |
| Y304 | Phosphorylation | P43405 (SYK) , P06241 (FYN) , P07948 (LYN) , P51451 (BLK) | Uniprot |
研究背景
Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.
Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN, HCK and SYK.
Cell membrane>Single-pass type I membrane protein.
Found on monocytes, neutrophils and eosinophil platelets.
Interacts with INPP5D/SHIP1 and INPPL1/SHIP2, regulating its function. Interacts with APCS and FGR. Interacts with HCK.
研究領域
· Cellular Processes > Transport and catabolism > Phagosome. (View pathway)
· Human Diseases > Infectious diseases: Parasitic > Leishmaniasis.
· Human Diseases > Infectious diseases: Bacterial > Staphylococcus aureus infection.
· Human Diseases > Infectious diseases: Bacterial > Tuberculosis.
· Human Diseases > Immune diseases > Systemic lupus erythematosus.
· Organismal Systems > Development > Osteoclast differentiation. (View pathway)
· Organismal Systems > Immune system > Platelet activation. (View pathway)
· Organismal Systems > Immune system > Fc gamma R-mediated phagocytosis. (View pathway)
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