BACH1/BRIP1 Antibody - #AF4789
| 製品: | BACH1/BRIP1 Antibody |
| カタログ: | AF4789 |
| タンパク質の説明: | Rabbit polyclonal antibody to BACH1/BRIP1 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse |
| 予測: | Pig, Bovine, Dog, Chicken |
| 分子量: | 145kDa; 141kD(Calculated). |
| ユニプロット: | Q9BX63 |
| RRID: | AB_2844609 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF4789, RRID:AB_2844609.
折りたたみ／展開
ATP dependent RNA helicase BRIP1; ATP-dependent RNA helicase BRIP1; BACH 1; BRAC 1 Associated C Terminal Helicase 1; BRCA 1 Interacting Protein 1; BRCA1 binding helicase like protein BACH1; BRCA1 interacting protein C terminal helicase 1; BRCA1-associated C-terminal helicase 1; BRCA1-interacting protein 1; BRCA1-interacting protein C-terminal helicase 1; BRCA1/BRCA2 associated helicase 1; BRIP 1; BRIP1; FANCJ; FANCJ_HUMAN; Fanconi anemia group J protein; FLJ90232; MGC126521; MGC126523; OF; Protein FACJ;
免疫原
- Q9BX63 FANCJ_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSSMWSEYTIGGVKIYFPYKAYPSQLAMMNSILRGLNSKQHCLLESPTGSGKSLALLCSALAWQQSLSGKPADEGVSEKAEVQLSCCCACHSKDFTNNDMNQGTSRHFNYPSTPPSERNGTSSTCQDSPEKTTLAAKLSAKKQASIYRDENDDFQVEKKRIRPLETTQQIRKRHCFGTEVHNLDAKVDSGKTVKLNSPLEKINSFSPQKPPGHCSRCCCSTKQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRRTAYSGVPMTILSSRDHTCVHPEVVGNFNRNEKCMELLDGKNGKSCYFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQDADIIFCPYNYLLDAQIRESMDLNLKEQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSMVNNNIRKKDHEPLRAVCCSLINWLEANAEYLVERDYESACKIWSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRFADDYKIAIQQTYSWTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKSFSSELGVTFTIQLEANHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVIVEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGRQWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPSSIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFNSLGQYFTGKIPKATPELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTVNTSFGSCPQSETIISSLKIDATLTRKNHSEHPLCSEEALDPDIELSLVSEEDKQSTSNRDFETEAEDESIYFTPELYDPEDTDEEKNDLAETDRGNRLANNSDCILAKDLFEIRTIKEVDSAREVKAEDCIDTKLNGILHIEESKIDDIDGNVKTTWINELELGKTHEIEIKNFKPSPSKNKGMFPGFK
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9BX63 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y22 | Phosphorylation | Uniprot | |
| K39 | Ubiquitination | Uniprot | |
| S77 | Phosphorylation | Uniprot | |
| Y110 | Phosphorylation | Uniprot | |
| S112 | Phosphorylation | Uniprot | |
| T113 | Phosphorylation | Uniprot | |
| S116 | Phosphorylation | Uniprot | |
| T124 | Phosphorylation | Uniprot | |
| S128 | Phosphorylation | Uniprot | |
| K137 | Ubiquitination | Uniprot | |
| S139 | Phosphorylation | Uniprot | |
| K142 | Ubiquitination | Uniprot | |
| K158 | Ubiquitination | Uniprot | |
| K186 | Acetylation | Uniprot | |
| K191 | Acetylation | Uniprot | |
| S197 | Phosphorylation | Uniprot | |
| S204 | Phosphorylation | Uniprot | |
| S206 | Phosphorylation | Uniprot | |
| K222 | Ubiquitination | Uniprot | |
| S226 | Phosphorylation | Uniprot | |
| S229 | Phosphorylation | Uniprot | |
| S230 | Phosphorylation | Uniprot | |
| T232 | Phosphorylation | Uniprot | |
| K254 | Ubiquitination | Uniprot | |
| T274 | Phosphorylation | Uniprot | |
| S278 | Phosphorylation | Uniprot | |
| K297 | Ubiquitination | Uniprot | |
| K345 | Ubiquitination | Uniprot | |
| K348 | Ubiquitination | Uniprot | |
| Y461 | Phosphorylation | Uniprot | |
| K503 | Ubiquitination | Uniprot | |
| S505 | Phosphorylation | Uniprot | |
| Y508 | Phosphorylation | Uniprot | |
| K510 | Ubiquitination | Uniprot | |
| T584 | Phosphorylation | Uniprot | |
| K656 | Ubiquitination | Uniprot | |
| Y742 | Phosphorylation | Uniprot | |
| K747 | Ubiquitination | Uniprot | |
| K764 | Ubiquitination | Uniprot | |
| K797 | Ubiquitination | Uniprot | |
| K862 | Ubiquitination | Uniprot | |
| S895 | Phosphorylation | Uniprot | |
| K897 | Ubiquitination | Uniprot | |
| Y916 | Phosphorylation | Uniprot | |
| T918 | Phosphorylation | Uniprot | |
| Y921 | Phosphorylation | Uniprot | |
| S927 | Phosphorylation | Uniprot | |
| S930 | Phosphorylation | Uniprot | |
| T953 | Phosphorylation | Uniprot | |
| K954 | Ubiquitination | Uniprot | |
| S956 | Phosphorylation | Uniprot | |
| K982 | Ubiquitination | Uniprot | |
| S988 | Phosphorylation | Uniprot | |
| S990 | Phosphorylation | Uniprot | |
| S1001 | Phosphorylation | Uniprot | |
| S1004 | Phosphorylation | Uniprot | |
| S1007 | Phosphorylation | Uniprot | |
| T1020 | Phosphorylation | Uniprot | |
| S1031 | Phosphorylation | Uniprot | |
| S1032 | Phosphorylation | Uniprot | |
| T1045 | Phosphorylation | Uniprot | |
| T1050 | Phosphorylation | Uniprot | |
| S1063 | Phosphorylation | Uniprot | |
| T1133 | Phosphorylation | Uniprot | |
| T1142 | Phosphorylation | Uniprot | |
| S1162 | Phosphorylation | Uniprot | |
| K1168 | Acetylation | Uniprot | |
| K1168 | Ubiquitination | Uniprot | |
| K1214 | Ubiquitination | Uniprot | |
| S1237 | Phosphorylation | Uniprot | |
| S1239 | Phosphorylation | Uniprot | |
| K1249 | Acetylation | Uniprot |
研究背景
DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1.
Phosphorylated. Phosphorylation is necessary for interaction with BRCA1, and is cell-cycle regulated.
Acetylation at Lys-1249 facilitates DNA end processing required for repair and checkpoint signaling.
Nucleus. Cytoplasm.
Ubiquitously expressed, with highest levels in testis.
Binds directly to the BRCT domains of BRCA1. Interacts with the CIA complex components CIAO1, CIAO2B and MMS19.
4Fe-4S iron-sulfur-binding is required for helicase activity.
Belongs to the DEAD box helicase family. DEAH subfamily.
研究領域
· Genetic Information Processing > Replication and repair > Homologous recombination.
· Genetic Information Processing > Replication and repair > Fanconi anemia pathway.
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