Phospho-VAV2 (Tyr142) Antibody - #AF4446
| 製品: | Phospho-VAV2 (Tyr142) Antibody |
| カタログ: | AF4446 |
| タンパク質の説明: | Rabbit polyclonal antibody to Phospho-VAV2 (Tyr142) |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Zebrafish, Horse, Chicken, Xenopus |
| 分子量: | 101kDa; 101kD(Calculated). |
| ユニプロット: | P52735 |
| RRID: | AB_2844631 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF4446, RRID:AB_2844631.
折りたたみ／展開
Guanine nucleotide exchange factor VAV2; Oncogene VAV2; Protein vav 2; VAV 2; Vav 2 oncogene; VAV-2; VAV2; VAV2 oncogene; VAV2_HUMAN;
免疫原
- P52735 VAV2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDINFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSIAQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEVQQPMIRYMQKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAVFINLEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKEALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKSHGKMWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKACKMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGNPAPPGKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSPASCASYNFSFLSPQGLSFASQGPSAPFWSVFTPRVIGTAVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEEEGIQ
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P52735 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S91 | Phosphorylation | Uniprot | |
| K124 | Ubiquitination | Uniprot | |
| Y142 | Phosphorylation | P06239 (LCK) , P00533 (EGFR) | Uniprot |
| Y159 | Phosphorylation | P06239 (LCK) , P00533 (EGFR) | Uniprot |
| Y172 | Phosphorylation | P06239 (LCK) , P00533 (EGFR) | Uniprot |
| K212 | Ubiquitination | Uniprot | |
| K385 | Ubiquitination | Uniprot | |
| K399 | Ubiquitination | Uniprot | |
| K407 | Ubiquitination | Uniprot | |
| K413 | Ubiquitination | Uniprot | |
| Y426 | Phosphorylation | Uniprot | |
| K515 | Acetylation | Uniprot | |
| K573 | Ubiquitination | Uniprot | |
| T575 | Phosphorylation | Uniprot | |
| S576 | Phosphorylation | Uniprot | |
| S583 | Phosphorylation | Uniprot | |
| S626 | Phosphorylation | Uniprot | |
| S639 | Phosphorylation | Uniprot | |
| S663 | Phosphorylation | Uniprot | |
| S692 | Phosphorylation | Uniprot | |
| K718 | Ubiquitination | Uniprot | |
| K757 | Ubiquitination | Uniprot | |
| S778 | Phosphorylation | Uniprot | |
| S779 | Phosphorylation | Uniprot | |
| S781 | Phosphorylation | Uniprot | |
| S836 | Phosphorylation | Uniprot |
研究背景
Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity).
Phosphorylated on tyrosine residues in response to FGR activation.
Widely expressed.
Interacts (via SH2 domains) with the phosphorylated form of EPHA2. Interacts with SSX2IP (By similarity). Interacts with NEK3 and PRLR and this interaction is prolactin-dependent.
研究領域
· Cellular Processes > Cellular community - eukaryotes > Focal adhesion. (View pathway)
· Cellular Processes > Cell motility > Regulation of actin cytoskeleton. (View pathway)
· Environmental Information Processing > Signal transduction > Rap1 signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > cAMP signaling pathway. (View pathway)
· Human Diseases > Cancers: Overview > Proteoglycans in cancer.
· Organismal Systems > Immune system > Chemokine signaling pathway. (View pathway)
· Organismal Systems > Immune system > Natural killer cell mediated cytotoxicity. (View pathway)
· Organismal Systems > Immune system > T cell receptor signaling pathway. (View pathway)
· Organismal Systems > Immune system > B cell receptor signaling pathway. (View pathway)
· Organismal Systems > Immune system > Fc epsilon RI signaling pathway. (View pathway)
· Organismal Systems > Immune system > Fc gamma R-mediated phagocytosis. (View pathway)
· Organismal Systems > Immune system > Leukocyte transendothelial migration. (View pathway)
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