Phospho-CD226/DNAM-1 (Ser329) Antibody - #AF4478
| 製品: | Phospho-CD226/DNAM-1 (Ser329) Antibody |
| カタログ: | AF4478 |
| タンパク質の説明: | Rabbit polyclonal antibody to Phospho-CD226/DNAM-1 (Ser329) |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Monkey |
| 予測: | Pig, Horse |
| 分子量: | 58kDa; 39kD(Calculated). |
| ユニプロット: | Q15762 |
| RRID: | AB_2844641 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF4478, RRID:AB_2844641.
折りたたみ／展開
adhesion glycoprotein; CD226; CD226 antigen; CD226 molecule; CD226_HUMAN; DNAM 1; DNAM-1; DNAM1; DNAX accessory molecule 1; platelet and T cell activation antigen 1; PTA1; T lineage specific activation antigen 1 antigen; TLiSA1;
免疫原
- Q15762 CD226_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDYPTLLLALLHVYRALCEEVLWHTSVPFAENMSLECVYPSMGILTQVEWFKIGTQQDSIAIFSPTHGMVIRKPYAERVYFLNSTMASNNMTLFFRNASEDDVGYYSCSLYTYPQGTWQKVIQVVQSDSFEAAVPSNSHIVSEPGKNVTLTCQPQMTWPVQAVRWEKIQPRQIDLLTYCNLVHGRNFTSKFPRQIVSNCSHGRWSVIVIPDVTVSDSGLYRCYLQASAGENETFVMRLTVAEGKTDNQYTLFVAGGTVLLLLFVISITTIIVIFLNRRRRRERRDLFTESWDTQKAPNNYRSPISTSQPTNQSMDDTREDIYVNYPTFSRRPKTRV
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q15762 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K167 | Ubiquitination | Uniprot | |
| Y249 | Phosphorylation | Uniprot | |
| T250 | Phosphorylation | Uniprot | |
| S290 | Phosphorylation | Uniprot | |
| T293 | Phosphorylation | Uniprot | |
| K295 | Ubiquitination | Uniprot | |
| S313 | Phosphorylation | Uniprot | |
| Y322 | Phosphorylation | P06241 (FYN) | Uniprot |
| Y325 | Phosphorylation | Uniprot | |
| S329 | Phosphorylation | P17252 (PRKCA) | Uniprot |
研究背景
Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding.
Cell membrane>Single-pass type I membrane protein.
Expressed by peripheral blood T-lymphocytes.
Interacts with PVR and NECTIN2. Competes with PVRIG for NECTIN2-binding.
研究領域
· Environmental Information Processing > Signaling molecules and interaction > Cell adhesion molecules (CAMs). (View pathway)
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