SIN3A Antibody - #AF4612
| 製品: | SIN3A Antibody |
| カタログ: | AF4612 |
| タンパク質の説明: | Rabbit polyclonal antibody to SIN3A |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 145kDa; 145kD(Calculated). |
| ユニプロット: | Q96ST3 |
| RRID: | AB_2844651 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF4612, RRID:AB_2844651.
折りたたみ／展開
AW553200; DKFZP434K2235; FLJ90319; Histone deacetylase complex subunit Sin 3a; Histone deacetylase complex subunit Sin3a; KIAA0700; Kiaa4126; mKIAA4126; Paired amphipathic helix protein Sin 3a; Paired amphipathic helix protein Sin3a; Sin 3a; SIN3 homolog A; SIN3 homolog A transcription regulator (yeast); SIN3 homolog A transcription regulator; SIN3 transcription regulator homolog A; Sin3a; SIN3A protein; SIN3A_HUMAN; Transcriptional co repressor Sin 3A; Transcriptional co repressor Sin3A; Transcriptional corepressor Sin3a; Transcriptional regulator SIN3A;
免疫原
Expressed in the developing brain, with highest levels of expression detected in the ventricular zone of various cortical regions.
- Q96ST3 SIN3A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKRRLDDQESPVYAAQQRRIPGSTEAFPHQHRVLAPAPPVYEAVSETMQSATGIQYSVTPSYQVSAMPQSSGSHGPAIAAVHSSHHHPTAVQPHGGQVVQSHAHPAPPVAPVQGQQQFQRLKVEDALSYLDQVKLQFGSQPQVYNDFLDIMKEFKSQSIDTPGVISRVSQLFKGHPDLIMGFNTFLPPGYKIEVQTNDMVNVTTPGQVHQIPTHGIQPQPQPPPQHPSQPSAQSAPAPAQPAPQPPPAKVSKPSQLQAHTPASQQTPPLPPYASPRSPPVQPHTPVTISLGTAPSLQNNQPVEFNHAINYVNKIKNRFQGQPDIYKAFLEILHTYQKEQRNAKEAGGNYTPALTEQEVYAQVARLFKNQEDLLSEFGQFLPDANSSVLLSKTTAEKVDSVRNDHGGTVKKPQLNNKPQRPSQNGCQIRRHPTGTTPPVKKKPKLLNLKDSSMADASKHGGGTESLFFDKVRKALRSAEAYENFLRCLVIFNQEVISRAELVQLVSPFLGKFPELFNWFKNFLGYKESVHLETYPKERATEGIAMEIDYASCKRLGSSYRALPKSYQQPKCTGRTPLCKEVLNDTWVSFPSWSEDSTFVSSKKTQYEEHIYRCEDERFELDVVLETNLATIRVLEAIQKKLSRLSAEEQAKFRLDNTLGGTSEVIHRKALQRIYADKAADIIDGLRKNPSIAVPIVLKRLKMKEEEWREAQRGFNKVWREQNEKYYLKSLDHQGINFKQNDTKVLRSKSLLNEIESIYDERQEQATEENAGVPVGPHLSLAYEDKQILEDAAALIIHHVKRQTGIQKEDKYKIKQIMHHFIPDLLFAQRGDLSDVEEEEEEEMDVDEATGAVKKHNGVGGSPPKSKLLFSNTAAQKLRGMDEVYNLFYVNNNWYIFMRLHQILCLRLLRICSQAERQIEEENREREWEREVLGIKRDKSDSPAIQLRLKEPMDVDVEDYYPAFLDMVRSLLDGNIDSSQYEDSLREMFTIHAYIAFTMDKLIQSIVRQLQHIVSDEICVQVTDLYLAENNNGATGGQLNTQNSRSLLESTYQRKAEQLMSDENCFKLMFIQSQGQVQLTIELLDTEEENSDDPVEAERWSDYVERYMNSDTTSPELREHLAQKPVFLPRNLRRIRKCQRGREQQEKEGKEGNSKKTMENVDSLDKLECRFKLNSYKMVYVIKSEDYMYRRTALLRAHQSHERVSKRLHQRFQAWVDKWTKEHVPREMAAETSKWLMGEGLEGLVPCTTTCDTETLHFVSINKYRVKYGTVFKAP
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q96ST3 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S10 | Phosphorylation | Uniprot | |
| Y13 | Phosphorylation | Uniprot | |
| S23 | Phosphorylation | Uniprot | |
| Y41 | Phosphorylation | Uniprot | |
| K122 | Ubiquitination | Uniprot | |
| K155 | Ubiquitination | Uniprot | |
| S166 | Phosphorylation | Uniprot | |
| S169 | Phosphorylation | Uniprot | |
| T260 | Phosphorylation | Uniprot | |
| T266 | Phosphorylation | Uniprot | |
| Y272 | Phosphorylation | Uniprot | |
| S274 | Phosphorylation | Uniprot | |
| S277 | Phosphorylation | Uniprot | |
| T284 | Phosphorylation | Uniprot | |
| S289 | Phosphorylation | Uniprot | |
| Y310 | Phosphorylation | Uniprot | |
| K337 | Ubiquitination | Uniprot | |
| K343 | Ubiquitination | Uniprot | |
| T350 | Phosphorylation | Uniprot | |
| K391 | Ubiquitination | Uniprot | |
| S421 | Phosphorylation | Uniprot | |
| T432 | Phosphorylation | Uniprot | |
| T434 | Phosphorylation | O14757 (CHEK1) | Uniprot |
| T435 | Phosphorylation | Uniprot | |
| S450 | Phosphorylation | Uniprot | |
| S451 | Phosphorylation | Uniprot | |
| K457 | Ubiquitination | Uniprot | |
| K469 | Acetylation | Uniprot | |
| S505 | Phosphorylation | Uniprot | |
| Y524 | Phosphorylation | Uniprot | |
| T539 | Phosphorylation | Uniprot | |
| C551 | S-Nitrosylation | Uniprot | |
| Y558 | Phosphorylation | Uniprot | |
| K563 | Ubiquitination | Uniprot | |
| Y565 | Phosphorylation | Uniprot | |
| T574 | Phosphorylation | Uniprot | |
| T584 | Phosphorylation | Uniprot | |
| K601 | Acetylation | Uniprot | |
| K601 | Ubiquitination | Uniprot | |
| Y610 | Phosphorylation | Uniprot | |
| S641 | Phosphorylation | Uniprot | |
| K650 | Ubiquitination | Uniprot | |
| K676 | Ubiquitination | Uniprot | |
| K697 | Ubiquitination | Uniprot | |
| K715 | Ubiquitination | Uniprot | |
| K723 | Acetylation | Uniprot | |
| K727 | Acetylation | Uniprot | |
| K727 | Ubiquitination | Uniprot | |
| K737 | Methylation | Uniprot | |
| S746 | Phosphorylation | Uniprot | |
| K747 | Ubiquitination | Uniprot | |
| S748 | Phosphorylation | Uniprot | |
| Y757 | Phosphorylation | Uniprot | |
| T802 | Phosphorylation | Uniprot | |
| S832 | Phosphorylation | Uniprot | |
| S860 | Phosphorylation | Uniprot | |
| K865 | Acetylation | Uniprot | |
| K865 | Ubiquitination | Uniprot | |
| K875 | Acetylation | Uniprot | |
| K875 | Ubiquitination | Uniprot | |
| K934 | Acetylation | Uniprot | |
| K934 | Ubiquitination | Uniprot | |
| K937 | Ubiquitination | Uniprot | |
| S938 | Phosphorylation | Uniprot | |
| S940 | Phosphorylation | Uniprot | |
| Y958 | Phosphorylation | Uniprot | |
| Y959 | Phosphorylation | Uniprot | |
| K1053 | Ubiquitination | Uniprot | |
| S1089 | Phosphorylation | Uniprot | |
| Y1101 | Phosphorylation | Uniprot | |
| Y1105 | Phosphorylation | Uniprot | |
| S1108 | Phosphorylation | Uniprot | |
| T1110 | Phosphorylation | Uniprot | |
| T1111 | Phosphorylation | Uniprot | |
| S1112 | Phosphorylation | Uniprot | |
| K1122 | Ubiquitination | Uniprot | |
| K1154 | Ubiquitination | Uniprot | |
| S1161 | Phosphorylation | Uniprot | |
| K1164 | Ubiquitination | Uniprot | |
| K1170 | Ubiquitination | Uniprot | |
| Y1178 | Phosphorylation | Uniprot | |
| K1219 | Ubiquitination | Uniprot | |
| S1231 | Phosphorylation | Uniprot | |
| K1232 | Ubiquitination | Uniprot | |
| K1271 | Ubiquitination | Uniprot |
研究背景
Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity).
SUMO1 sumoylated by TOPORS. Probably desumoylated by SENP2.
Nucleus. Nucleus>Nucleolus.
Note: Recruited to the nucleolus by SAP30L.
Expressed in the developing brain, with highest levels of expression detected in the ventricular zone of various cortical regions.
Interacts with ARID4B, BRMS1L, HCFC1, HDAC1, HDAC2, MXI1, SAP30L, SAP130, SFPQ and TOPORS. Interacts with OGT (via TPRs 1-6); the interaction mediates transcriptional repression in parallel with histone deacetylase. Interacts with BAZ2A, MXD1, MXD3, MXD4, MBD2, DACH1, NCOR1, NR4A2, REST, RLIM, SAP30, SETDB1, SMYD2, and SUDS3. Interacts with PHF12 in a complex composed of HDAC1, PHF12 and SAP30 (By similarity). Interacts with TET1; the interaction recruits SIN3A to gene promoters. The large PER complex involved in the histone deacetylation is composed of at least HDAC1, PER2, SFPQ and SIN3A (By similarity). Interacts with KLF11 (By similarity). Interacts with PPHLN1. Found in a complex with YY1, GON4L and HDAC1 (By similarity). Interacts (via PAH2) with FOXK1 (By similarity). Interacts with FOXK2 (By similarity). Found in a complex composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1. Interacts with SINHCAF (By similarity). Interacts with SPHK2.
研究領域
· Human Diseases > Neurodegenerative diseases > Huntington's disease.
· Human Diseases > Cancers: Overview > Transcriptional misregulation in cancer.
· Organismal Systems > Endocrine system > Thyroid hormone signaling pathway. (View pathway)
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