IRAK3 Antibody - #AF4677
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製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF4677, RRID:AB_2844683.
折りたたみ／展開
ASRT5; IL 1 receptor associated kinase M; IL-1 receptor-associated kinase M; IL1 receptor associated kinase M; Interleukin 1 receptor associated kinase 3; Interleukin 1 receptor associated kinase M; Interleukin-1 receptor-associated kinase 3; IRAK M; IRAK-3; IRAK-M; Irak3; IRAK3_HUMAN;
免疫原
- Q9Y616 IRAK3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAGNCGARGALSAHTLLFDLPPALLGELCAVLDSCDGALGWRGLAERLSSSWLDVRHIEKYVDQGKSGTRELLWSWAQKNKTIGDLLQVLQEMGHRRAIHLITNYGAVLSPSEKSYQEGGFPNILFKETANVTVDNVLIPEHNEKGILLKSSISFQNIIEGTRNFHKDFLIGEGEIFEVYRVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDPPTSLKSFRCPSPLFLENVPSIPVEDDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPSSSCEESWFPKYIVPSQDLRPYKVNIDPSSEAPGHSCRSRPVESSCSSKFSWDEYEQYKKE
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9Y616 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y61 | Phosphorylation | Uniprot | |
| S67 | Phosphorylation | Uniprot | |
| S110 | Phosphorylation | Uniprot | |
| S115 | Phosphorylation | Uniprot | |
| S154 | Phosphorylation | Uniprot | |
| T162 | Phosphorylation | Uniprot | |
| T188 | Phosphorylation | Uniprot | |
| Y189 | Phosphorylation | Uniprot | |
| K199 | Acetylation | Uniprot | |
| K379 | Ubiquitination | Uniprot | |
| S398 | Phosphorylation | Uniprot | |
| S401 | Phosphorylation | Uniprot | |
| S467 | Phosphorylation | Uniprot | |
| S484 | Phosphorylation | Uniprot | |
| S510 | Phosphorylation | Uniprot | |
| S512 | Phosphorylation | Uniprot |
研究背景
Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.
Expressed predominantly in peripheral blood lymphocytes.
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
研究領域
· Organismal Systems > Nervous system > Neurotrophin signaling pathway. (View pathway)
参考文献
Application: WB Species: Rat Sample:
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