IFT88 Antibody - #DF12001
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12001, RRID:AB_2844806.
折りたたみ／展開
D13S1056E; DAF19; hTg737; Ift88; IFT88_HUMAN; Intraflagellar transport 88 homolog; Intraflagellar transport protein 88 homolog; MGC26259; Polaris homolog; Probe hTg737 (polycystic kidney disease, autosomal recessive); Recessive polycystic kidney disease protein Tg737 homolog; RP11-172H24.2; Tetratricopeptide repeat domain 10; Tetratricopeptide repeat protein 10; TG737; TPR repeat protein 10; TTC10;
免疫原
Expressed in the heart, brain, liver, lung, kidney, skeletal muscle and pancreas.
- Q13099 IFT88_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKFTNTKVQMMQNVHLAPETDEDDLYSGYNDYNPIYDIEELENDAAFQQAVRTSHGRRPPITAKISSTAVTRPIATGYGSKTSLASSIGRPMTGAIQDGVTRPMTAVRAAGFTKAALRGSAFDPLSQSRGPASPLEAKKKDSPEEKIKQLEKEVNELVEESCIANSCGDLKLALEKAKDAGRKERVLVRQREQVTTPENINLDLTYSVLFNLASQYSVNEMYAEALNTYQVIVKNKMFSNAGILKMNMGNIYLKQRNYSKAIKFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAPNLKAGYNLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIKNDHLRQMERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQYVELANDLEINKAVTYLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLCTDLGLKDAQEYARKLKRLEKMKEIREQRIKSGRDGSGGSRGKREGSASGDSGQNYSASSKGERLSARLRALPGTNEPYESSSNKEIDASYVDPLGPQIERPKTAAKKRIDEDDFADEELGDDLLPE
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q13099 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S66 | Phosphorylation | Uniprot | |
| S80 | Phosphorylation | Uniprot | |
| K114 | Ubiquitination | Uniprot | |
| S128 | Phosphorylation | Uniprot | |
| S133 | Phosphorylation | Uniprot | |
| K236 | Ubiquitination | Uniprot | |
| Y252 | Phosphorylation | Uniprot | |
| K254 | Ubiquitination | Uniprot | |
| Y258 | Phosphorylation | Uniprot | |
| S259 | Phosphorylation | Uniprot | |
| K263 | Ubiquitination | Uniprot | |
| K277 | Ubiquitination | Uniprot | |
| K335 | Ubiquitination | Uniprot | |
| K339 | Ubiquitination | Uniprot | |
| K351 | Ubiquitination | Uniprot | |
| K369 | Ubiquitination | Uniprot | |
| K386 | Ubiquitination | Uniprot | |
| K430 | Ubiquitination | Uniprot | |
| K438 | Ubiquitination | Uniprot | |
| K448 | Acetylation | Uniprot | |
| K448 | Ubiquitination | Uniprot | |
| K452 | Acetylation | Uniprot | |
| K453 | Acetylation | Uniprot | |
| K458 | Ubiquitination | Uniprot | |
| K499 | Ubiquitination | Uniprot | |
| K511 | Ubiquitination | Uniprot | |
| K517 | Ubiquitination | Uniprot | |
| Y619 | Phosphorylation | Uniprot | |
| Y622 | Phosphorylation | Uniprot | |
| K681 | Ubiquitination | Uniprot | |
| K687 | Ubiquitination | Uniprot | |
| K713 | Ubiquitination | Uniprot | |
| S743 | Phosphorylation | Uniprot | |
| S746 | Phosphorylation | Uniprot | |
| S753 | Phosphorylation | Uniprot | |
| S758 | Phosphorylation | Uniprot | |
| Y762 | Phosphorylation | Uniprot | |
| S765 | Phosphorylation | Uniprot | |
| S766 | Phosphorylation | Uniprot | |
| K814 | Acetylation | Uniprot |
研究背景
Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment.
Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome>Centriole. Cell projection>Cilium. Cytoplasm>Cytoskeleton>Cilium basal body. Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome. Cytoplasm. Cell projection>Cilium>Flagellum.
Note: Colocalizes with ENTR1 and gamma-tubulin at the basal body of primary cilia. Colocalizes with ENTR1 and pericentrin at the centrosome.
Expressed in the heart, brain, liver, lung, kidney, skeletal muscle and pancreas.
Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT20, IFT22, HSPB11, IFT27, IFT46, IFT52, TRAF3IP1, IFT57, IFT74, IFT80, IFT81, IFT88 AND IFT172. Interacts with C2CD3. Interacts with ENTR1 (via N-terminus). Interacts with LRRC56.
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