PYCR1 Antibody - #DF12051
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12051, RRID:AB_2844856.
折りたたみ／展開
P5C; P5C reductase 1; P5C reductase; P5CR 1; P5CR; PIG45; PP222; Proliferation inducing protein 45; PYCR 1; PYCR; Pyrroline 5 carboxylate reductase 1; Pyrroline 5 carboxylate reductase 1 mitochondrial;
免疫原
- P32322 P5CR1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGVKLTPHNKETVQHSDVLFLAVKPHIIPFILDEIGADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPRVIRCMTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVGFCTEVEEDLIDAVTGLSGSGPAYAFTALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSPGGATIHALHVLESGGFRSLLINAVEASCIRTRELQSMADQEQVSPAAIKKTILDKVKLDSPAGTALSPSGHTKLLPRSLAPAGKD
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P32322 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| K51 | Ubiquitination | Uniprot | |
| K215 | Acetylation | Uniprot | |
| K215 | Ubiquitination | Uniprot | |
| K228 | Ubiquitination | Uniprot | |
| S233 | Phosphorylation | Uniprot | |
| T238 | Phosphorylation | Uniprot | |
| S261 | Phosphorylation | Uniprot | |
| C262 | S-Nitrosylation | Uniprot | |
| S270 | Phosphorylation | Uniprot | |
| S278 | Phosphorylation | Uniprot | |
| K283 | Ubiquitination | Uniprot | |
| K289 | Ubiquitination | Uniprot | |
| K291 | Ubiquitination | Uniprot | |
| S294 | Phosphorylation | Uniprot | |
| T298 | Phosphorylation | Uniprot | |
| S301 | Phosphorylation | P24941 (CDK2) | Uniprot |
| S303 | Phosphorylation | P24941 (CDK2) | Uniprot |
研究背景
Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress.
Mitochondrion.
Homodecamer; composed of 5 homodimers Ref.18). Interacts with LTO1.
Belongs to the pyrroline-5-carboxylate reductase family.
研究領域
· Metabolism > Amino acid metabolism > Arginine and proline metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Metabolism > Global and overview maps > Biosynthesis of amino acids.
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