Cyclin L1 Antibody - #AF0236
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF0236, RRID:AB_2833411.
折りたたみ／展開
Ania 6a; CCNL1; CCNL1_HUMAN; Cyclin L; Cyclin L gamma; Cyclin L1; Cyclin-L; Cyclin-L1;
免疫原
Widely expressed. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC).
- Q9UK58 CCNL1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASGPHSTATAAAAASSAAPSAGGSSSGTTTTTTTTTGGILIGDRLYSEVSLTIDHSLIPEERLSPTPSMQDGLDLPSETDLRILGCELIQAAGILLRLPQVAMATGQVLFHRFFYSKSFVKHSFEIVAMACINLASKIEEAPRRIRDVINVFHHLRQLRGKRTPSPLILDQNYINTKNQVIKAERRVLKELGFCVHVKHPHKIIVMYLQVLECERNQTLVQTAWNYMNDSLRTNVFVRFQPETIACACIYLAARALQIPLPTRPHWFLLFGTTEEEIQEICIETLRLYTRKKPNYELLEKEVEKRKVALQEAKLKAKGLNPDGTPALSTLGGFSPASKPSSPREVKAEEKSPISINVKTVKKEPEDRQQASKSPYNGVRKDSKRSRNSRSASRSRSRTRSRSRSHTPRRHYNNRRSRSGTYSSRSRSRSRSHSESPRRHHNHGSPHLKAKHTRDDLKSSNRHGHKRKKSRSRSQSKSRDHSDAAKKHRHERGHHRDRRERSRSFERSHKSKHHGGSRSGHGRHRR
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9UK58 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T30 | Phosphorylation | Uniprot | |
| T32 | Phosphorylation | Uniprot | |
| T33 | Phosphorylation | Uniprot | |
| T37 | Phosphorylation | Uniprot | |
| S65 | Phosphorylation | Uniprot | |
| T67 | Phosphorylation | Uniprot | |
| S166 | Phosphorylation | Uniprot | |
| K178 | Ubiquitination | Uniprot | |
| Y289 | Phosphorylation | Uniprot | |
| T325 | Phosphorylation | Uniprot | |
| S329 | Phosphorylation | Uniprot | |
| T330 | Phosphorylation | Uniprot | |
| S335 | Phosphorylation | Uniprot | |
| S338 | Phosphorylation | Uniprot | |
| S341 | Phosphorylation | Uniprot | |
| S342 | Phosphorylation | Uniprot | |
| S352 | Phosphorylation | Uniprot | |
| S355 | Phosphorylation | Uniprot | |
| S372 | Phosphorylation | Uniprot | |
| S374 | Phosphorylation | Uniprot | |
| Y376 | Phosphorylation | Uniprot | |
| S401 | Phosphorylation | Uniprot | |
| S403 | Phosphorylation | Uniprot | |
| S405 | Phosphorylation | Uniprot | |
| S417 | Phosphorylation | Uniprot | |
| S419 | Phosphorylation | Uniprot | |
| T421 | Phosphorylation | Uniprot | |
| Y422 | Phosphorylation | Uniprot | |
| S424 | Phosphorylation | Uniprot | |
| S445 | Phosphorylation | Uniprot | |
| K449 | Acetylation | Uniprot | |
| K451 | Acetylation | Uniprot | |
| S470 | Phosphorylation | Uniprot | |
| R471 | Methylation | Uniprot | |
| R473 | Methylation | Uniprot | |
| K486 | Ubiquitination | Uniprot | |
| K487 | Ubiquitination | Uniprot | |
| S502 | Phosphorylation | Uniprot | |
| S504 | Phosphorylation | Uniprot | |
| K512 | Methylation | Uniprot |
研究背景
Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs). Inhibited by the CDK-specific inhibitor CDKN1A/p21. May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC).
Nucleus speckle. Nucleus>Nucleoplasm.
Note: Found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing.
Widely expressed. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC).
Interacts with POLR2A via its hyperphosphorylated C-terminal domain (CTD) (By similarity). Interacts with CDK11A, CDK12 and CDK13. Isoforms 1 and 2, but not isoform 3, interact with CDK11B. May form a ternary complex with CDK11B and casein kinase II (CKII). Interacts with pre-mRNA-splicing factors, including at least SRSF1, SRSF2 AND SRSF7/SLU7.
Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions.
Belongs to the cyclin family. Cyclin L subfamily.
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