GLUD1 Antibody - #DF12116
| 製品: | GLUD1 Antibody |
| カタログ: | DF12116 |
| タンパク質の説明: | Rabbit polyclonal antibody to GLUD1 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Bovine, Sheep, Rabbit, Chicken, Xenopus |
| 分子量: | 45-55 kDa; 61kD(Calculated). |
| ユニプロット: | P00367 |
| RRID: | AB_2844921 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12116, RRID:AB_2844921.
折りたたみ／展開
AI118167; DHE3_HUMAN; EC 1.4.1.3; GDH 1; GDH; Gdh-X; GDH1; GLUD; Glud1; Glud1a; Glud1b; Gludl; Glutamate dehydrogenase (NAD(P)+); Glutamate dehydrogenase 1; Glutamate dehydrogenase 1 mitochondrial; Glutamate dehydrogenase 1a; Glutamate dehydrogenase 1b; Memory-related gene 2 protein; MGC127177; MGC132003; MGC80801; MGC93608; mitochondrial; MRG-2;
免疫原
- P00367 DHE3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MYRYLGEALLLSRAGPAALGSASADSAALLGWARGQPAAAPQPGLALAARRHYSEAVADREDDPNFFKMVEGFFDRGASIVEDKLVEDLRTRESEEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTDNELEKITRRFTMELAKKGFIGPGIDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFGDKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKPYEGSILEADCDILIPAASEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGKHGGTIPIVPTAEFQDRISGASEKDIVHSGLAYTMERSARQIMRTAMKYNLGLDLRTAAYVNAIEKVFKVYNEAGVTFT
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P00367 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K68 | Acetylation | Uniprot | |
| R76 | Methylation | Uniprot | |
| S79 | Phosphorylation | Uniprot | |
| K84 | Acetylation | Uniprot | |
| K84 | Ubiquitination | Uniprot | |
| K98 | Acetylation | Uniprot | |
| C112 | S-Nitrosylation | Uniprot | |
| S128 | Phosphorylation | Uniprot | |
| Y135 | Phosphorylation | Uniprot | |
| S153 | Phosphorylation | Uniprot | |
| T154 | Phosphorylation | Uniprot | |
| S157 | Phosphorylation | Uniprot | |
| K162 | Acetylation | Uniprot | |
| K162 | Ubiquitination | Uniprot | |
| Y170 | Phosphorylation | Uniprot | |
| K171 | Methylation | Uniprot | |
| K183 | Sumoylation | Uniprot | |
| K183 | Ubiquitination | Uniprot | |
| K187 | Ubiquitination | Uniprot | |
| K191 | Ubiquitination | Uniprot | |
| T194 | Phosphorylation | Uniprot | |
| K200 | Ubiquitination | Uniprot | |
| T206 | Phosphorylation | Uniprot | |
| K211 | Acetylation | Uniprot | |
| K211 | Ubiquitination | Uniprot | |
| K212 | Ubiquitination | Uniprot | |
| S227 | Phosphorylation | Uniprot | |
| T228 | Phosphorylation | Uniprot | |
| K302 | Methylation | Uniprot | |
| S316 | Phosphorylation | Uniprot | |
| S333 | Phosphorylation | Uniprot | |
| S336 | Phosphorylation | Uniprot | |
| K346 | Acetylation | Uniprot | |
| K352 | Acetylation | Uniprot | |
| K352 | Ubiquitination | Uniprot | |
| S357 | Phosphorylation | Uniprot | |
| K363 | Ubiquitination | Uniprot | |
| K365 | Ubiquitination | Uniprot | |
| Y367 | Phosphorylation | Uniprot | |
| S370 | Phosphorylation | Uniprot | |
| S384 | Phosphorylation | Uniprot | |
| K386 | Ubiquitination | Uniprot | |
| K390 | Acetylation | Uniprot | |
| K390 | Ubiquitination | Uniprot | |
| K399 | Ubiquitination | Uniprot | |
| T409 | Phosphorylation | Uniprot | |
| T410 | Phosphorylation | Uniprot | |
| K415 | Acetylation | Uniprot | |
| K415 | Ubiquitination | Uniprot | |
| S438 | Phosphorylation | Uniprot | |
| Y439 | Phosphorylation | Uniprot | |
| S450 | Phosphorylation | Uniprot | |
| Y451 | Phosphorylation | Uniprot | |
| K457 | Acetylation | Uniprot | |
| S462 | Phosphorylation | Uniprot | |
| Y464 | Phosphorylation | Uniprot | |
| K480 | Acetylation | Uniprot | |
| K480 | Ubiquitination | Uniprot | |
| R496 | Methylation | Uniprot | |
| K503 | Acetylation | Uniprot | |
| K503 | Ubiquitination | Uniprot | |
| Y512 | Phosphorylation | Uniprot | |
| T513 | Phosphorylation | Uniprot | |
| K527 | Acetylation | Uniprot | |
| K527 | Ubiquitination | Uniprot | |
| Y528 | Phosphorylation | Uniprot | |
| Y539 | Phosphorylation | Uniprot | |
| K545 | Acetylation | Uniprot | |
| K545 | Ubiquitination | Uniprot | |
| Y550 | Phosphorylation | Uniprot |
研究背景
Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity).
ADP-ribosylated by SIRT4, leading to inactivate glutamate dehydrogenase activity (By similarity). Stoichiometry shows that ADP-ribosylation occurs in one subunit per catalytically active homohexamer.
Mitochondrion matrix.
Homohexamer.
Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
研究領域
· Cellular Processes > Cell growth and death > Necroptosis. (View pathway)
· Metabolism > Amino acid metabolism > Arginine biosynthesis.
· Metabolism > Amino acid metabolism > Alanine, aspartate and glutamate metabolism.
· Metabolism > Metabolism of other amino acids > D-Glutamine and D-glutamate metabolism.
· Metabolism > Energy metabolism > Nitrogen metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Metabolism > Global and overview maps > Carbon metabolism.
· Organismal Systems > Excretory system > Proximal tubule bicarbonate reclamation.
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