RAB3D Antibody - #DF12135
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12135, RRID:AB_2844940.
折りたたみ／展開
D2-2; Glioblastoma overexpressed; GOV; RAB 16; RAB16; Rab3d; Rab3D upregulated with myeloid differentiation; RAB3D, member RAS oncogene family; RAB3D_HUMAN; RAD3D; Ras-related protein Rab-3D;
免疫原
Highly expressed in granulocytes of peripheral blood. Constitutively expressed at low levels in all hematopoietic cell lines investigated.
- O95716 RAB3D_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASAGDTQAGPRDAADQNFDYMFKLLLIGNSSVGKTSFLFRYADDSFTPAFVSTVGIDFKVKTVYRHDKRIKLQIWDTAGQERYRTITTAYYRGAMGFLLMYDIANQESFAAVQDWATQIKTYSWDNAQVILVGNKCDLEDERVVPAEDGRRLADDLGFEFFEASAKENINVKQVFERLVDVICEKMNESLEPSSSSGSNGKGPAVGDAPAPQPSSCSC
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O95716 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| S3 | Phosphorylation | Uniprot | |
| Y21 | Phosphorylation | Uniprot | |
| T78 | Phosphorylation | Uniprot | |
| T88 | Phosphorylation | Uniprot | |
| Y91 | Phosphorylation | Uniprot |
研究背景
Protein transport. Probably involved in regulated exocytosis (By similarity).
Phosphorylation of Thr-86 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM and CHML.
Cell membrane>Lipid-anchor>Cytoplasmic side.
Highly expressed in granulocytes of peripheral blood. Constitutively expressed at low levels in all hematopoietic cell lines investigated.
Interacts with RIMS1, RIMS2, RPH3A, RPH3AL and RAB3IP (By similarity). Interacts with CHM and CHML; phosphorylation at Thr-86 disrupts these interactions.
Belongs to the small GTPase superfamily. Rab family.
研究領域
· Organismal Systems > Digestive system > Pancreatic secretion.
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