ADRM1 Antibody - #DF12142
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12142, RRID:AB_2844947.
折りたたみ／展開
110 kDa cell membrane glycoprotein; adhesion regulating molecule 1; Adhesion-regulating molecule 1; ADRM 1; Adrm1; ADRM1_HUMAN; ARM 1; ARM-1; ARM1; Gp110; hRpn13; M(r) 110,000 surface antigen; Proteasomal ubiquitin receptor ADRM1; proteasome regulatory particle non ATPase 13; Proteasome regulatory particle non-ATPase 13; Regulatory particle non ATPase 13; Rpn13; Rpn13 homolog;
免疫原
- Q16186 ADRM1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTTSGALFPSLVPGSRGASNKYLVEFRAGKMSLKGTTVTPDKRKGLVYIQQTDDSLIHFCWKDRTSGNVEDDLIIFPDDCEFKRVPQCPSGRVYVLKFKAGSKRLFFWMQEPKTDQDEEHCRKVNEYLNNPPMPGALGASGSSGHELSALGGEGGLQSLLGNMSHSQLMQLIGPAGLGGLGGLGALTGPGLASLLGSSGPPGSSSSSSSRSQSAAVTPSSTTSSTRATPAPSAPAAASATSPSPAPSSGNGASTAASPTQPIQLSDLQSILATMNVPAGPAGGQQVDLASVLTPEIMAPILANADVQERLLPYLPSGESLPQTADEIQNTLTSPQFQQALGMFSAALASGQLGPLMCQFGLPAEAVEAANKGDVEAFAKAMQNNAKPEQKEGDTKDKKDEEEDMSLD
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q16186 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T2 | Acetylation | Uniprot | |
| T2 | Phosphorylation | Uniprot | |
| T3 | Phosphorylation | Uniprot | |
| S4 | Phosphorylation | Uniprot | |
| S10 | Phosphorylation | Uniprot | |
| S15 | Phosphorylation | Uniprot | |
| S19 | Phosphorylation | Uniprot | |
| K21 | Acetylation | Uniprot | |
| K21 | Ubiquitination | Uniprot | |
| Y22 | Phosphorylation | Uniprot | |
| R27 | Methylation | Uniprot | |
| S32 | Phosphorylation | Uniprot | |
| K34 | Methylation | Uniprot | |
| K34 | Ubiquitination | Uniprot | |
| T37 | Phosphorylation | Uniprot | |
| T39 | Phosphorylation | Uniprot | |
| K42 | Methylation | Uniprot | |
| K42 | Ubiquitination | Uniprot | |
| K62 | Ubiquitination | Uniprot | |
| K83 | Acetylation | Uniprot | |
| K83 | Ubiquitination | Uniprot | |
| K97 | Ubiquitination | Uniprot | |
| K113 | Ubiquitination | Uniprot | |
| Y127 | Phosphorylation | Uniprot | |
| S140 | Phosphorylation | Uniprot | |
| S142 | Phosphorylation | Uniprot | |
| S143 | Phosphorylation | Uniprot | |
| S211 | Phosphorylation | Uniprot | |
| S213 | Phosphorylation | Uniprot | |
| T217 | Phosphorylation | Uniprot | |
| S220 | Phosphorylation | Uniprot | |
| T221 | Phosphorylation | Uniprot | |
| T222 | Phosphorylation | Uniprot | |
| S224 | Phosphorylation | Uniprot | |
| K371 | Ubiquitination | Uniprot | |
| K379 | Ubiquitination | Uniprot | |
| K386 | Ubiquitination | Uniprot | |
| K390 | Ubiquitination | Uniprot | |
| K395 | Ubiquitination | Uniprot | |
| K397 | Ubiquitination | Uniprot | |
| K398 | Ubiquitination | Uniprot | |
| S405 | Phosphorylation | Uniprot |
研究背景
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation. UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex.
Cytoplasm. Nucleus.
Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). Interacts with the proteasomal scaffolding protein PSMD1. Interacts with deubiquitinase UCHL5; this interaction activates the auto-inhibited UCHL5 by deoligomerizing it. Interacts with UBQLN2 and ubiquitin.
The Pru (pleckstrin-like receptor for ubiquitin) domain mediates interactions with PSMD1 and ubiquitin. Preferential binding to the proximal subunit of K48-linked diubiquitin allows UCHL5 access to the distal subunit.
Belongs to the ADRM1 family.
研究領域
· Genetic Information Processing > Folding, sorting and degradation > Proteasome.
· Human Diseases > Infectious diseases: Viral > Epstein-Barr virus infection.
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