製品: ELAC2 Antibody
カタログ: DF12153
タンパク質の説明: Rabbit polyclonal antibody to ELAC2
アプリケーション: WB IHC
反応性: Human, Mouse, Rat
予測: Pig, Bovine, Horse, Sheep, Rabbit, Dog
分子量: 92 kDa; 92kD(Calculated).
ユニプロット: Q9BQ52
RRID: AB_2844958

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 100ul $280 在庫あり
 200ul $350 在庫あり

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Pig(100%), Bovine(100%), Horse(92%), Sheep(100%), Rabbit(100%), Dog(100%)
クローナリティ:
Polyclonal
特異性:
ELAC2 Antibody detects endogenous levels of total ELAC2.
RRID:
AB_2844958
引用形式: Affinity Biosciences Cat# DF12153, RRID:AB_2844958.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

COXPD17; elaC homolog 2 (E. coli); ElaC homolog protein 2; elaC ribonuclease Z 2; elaC, E. coli, homolog of, 2; ELAC2; ELC2; FLJ10530; FLJ36693; FLJ42848; Heredity prostate cancer protein 2; HPC2; putative prostate cancer susceptibility protein HPC2/ELAC2; Ribonuclease Z 2; Ribonuclease Z, long form; Ribonuclease Z2; RNase Z 2; RNase Z2; RNase ZL; RNZ2_HUMAN; tRNA 3 endonuclease 2; tRNase Z (long form); tRNase Z 2; tRNase Z2; Zinc phosphodiesterase ELAC protein 2;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
発現特異性:
Q9BQ52 RNZ2_HUMAN:

Widely expressed. Highly expressed in heart, placenta, liver, skeletal muscle, kidney, pancreas, testis and ovary. Weakly expressed in brain, lung, spleen, thymus, prostate, small intestine, colon and leukocytes.

タンパク質配列:
MWALCSLLRSAAGRTMSQGRTISQAPARRERPRKDPLRHLRTREKRGPSGCSGGPNTVYLQVVAAGSRDSGAALYVFSEFNRYLFNCGEGVQRLMQEHKLKVARLDNIFLTRMHWSNVGGLSGMILTLKETGLPKCVLSGPPQLEKYLEAIKIFSGPLKGIELAVRPHSAPEYEDETMTVYQIPIHSEQRRGKHQPWQSPERPLSRLSPERSSDSESNENEPHLPHGVSQRRGVRDSSLVVAFICKLHLKRGNFLVLKAKEMGLPVGTAAIAPIIAAVKDGKSITHEGREILAEELCTPPDPGAAFVVVECPDESFIQPICENATFQRYQGKADAPVALVVHMAPASVLVDSRYQQWMERFGPDTQHLVLNENCASVHNLRSHKIQTQLNLIHPDIFPLLTSFRCKKEGPTLSVPMVQGECLLKYQLRPRREWQRDAIITCNPEEFIVEALQLPNFQQSVQEYRRSAQDGPAPAEKRSQYPEIIFLGTGSAIPMKIRNVSATLVNISPDTSLLLDCGEGTFGQLCRHYGDQVDRVLGTLAAVFVSHLHADHHTGLPSILLQRERALASLGKPLHPLLVVAPNQLKAWLQQYHNQCQEVLHHISMIPAKCLQEGAEISSPAVERLISSLLRTCDLEEFQTCLVRHCKHAFGCALVHTSGWKVVYSGDTMPCEALVRMGKDATLLIHEATLEDGLEEEAVEKTHSTTSQAISVGMRMNAEFIMLNHFSQRYAKVPLFSPNFSEKVGVAFDHMKVCFGDFPTMPKLIPPLKALFAGDIEEMEERREKRELRQVRAALLSRELAGGLEDGEPQQKRAHTEEPQAKKVRAQ

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Horse
92
Zebrafish
75
Chicken
50
Xenopus
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q9BQ52 基板として

Site PTM Type Enzyme
R28 Methylation
K99 Methylation
K101 Methylation
K135 Ubiquitination
K146 Ubiquitination
K152 Acetylation
K152 Ubiquitination
Y181 Phosphorylation
K193 Ubiquitination
S199 Phosphorylation
S205 Phosphorylation
S208 Phosphorylation
S212 Phosphorylation
S213 Phosphorylation
S215 Phosphorylation
S217 Phosphorylation
S229 Phosphorylation
S238 Phosphorylation
K260 Ubiquitination
K279 Acetylation
K279 Ubiquitination
K282 Ubiquitination
K332 Ubiquitination
K384 Ubiquitination
K407 Ubiquitination
K424 Ubiquitination
K476 Ubiquitination
K495 Ubiquitination
Y528 Phosphorylation
K571 Ubiquitination
K608 Ubiquitination
S618 Phosphorylation
K678 Ubiquitination
T688 Phosphorylation
T701 Phosphorylation
K731 Ubiquitination
S736 Phosphorylation
S740 Phosphorylation
K742 Ubiquitination
K751 Ubiquitination
K762 Ubiquitination
K768 Ubiquitination
K811 Ubiquitination

研究背景

機能:

Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

細胞の位置付け:

Mitochondrion. Nucleus.
Note: Mainly mitochondrial.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Widely expressed. Highly expressed in heart, placenta, liver, skeletal muscle, kidney, pancreas, testis and ovary. Weakly expressed in brain, lung, spleen, thymus, prostate, small intestine, colon and leukocytes.

サブユニット構造:

Homodimer (By similarity). Interacts with PTCD1.

タンパク質ファミリー:

Belongs to the RNase Z family.

研究領域

· Genetic Information Processing > Translation > RNA transport.

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