GPX7 Antibody - #DF12156

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製品: GPX7 Antibody
カタログ: DF12156
タンパク質の説明: Rabbit polyclonal antibody to GPX7
アプリケーション: WB IHC
反応性: Human, Mouse
予測: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
分子量: 21 kDa; 21kD(Calculated).
ユニプロット: Q96SL4
RRID: AB_2844961

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関連ダウンロード
MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse
予測:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(92%), Dog(91%), Chicken(83%), Xenopus(92%)
クローナリティ:
Polyclonal
特異性:
GPX7 Antibody detects endogenous levels of total GPX7.
RRID:
AB_2844961
引用形式: Affinity Biosciences Cat# DF12156, RRID:AB_2844961.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

CL683; FLJ14777; Glutathione peroxidase 7; GPx-7; GPX6; GPX7; GPX7_HUMAN; GSHPx-7; NPGPx;

免疫原

免疫原:
Uniprot:

Q96SL4(GPX7_HUMAN) >>Visit HPA database.

遺伝子(ID):
GPX7(2882)
発現特異性:
Q96SL4 GPX7_HUMAN:

Expressed in esophageal epithelial cells; expression is up-regulated after exposure to acidic bile acids.

タンパク質配列:
MVAATVAAAWLLLWAAACAQQEQDFYDFKAVNIRGKLVSLEKYRGSVSLVVNVASECGFTDQHYRALQQLQRDLGPHHFNVLAFPCNQFGQQEPDSNKEIESFARRTYSVSFPMFSKIAVTGTGAHPAFKYLAQTSGKEPTWNFWKYLVAPDGKVVGAWDPTVSVEEVRPQITALVRKLILLKREDL

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Xenopus
92
Rabbit
92
Dog
91
Chicken
83
Zebrafish
75
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q96SL4 基板として

Site PTM Type Enzyme
Y147 Phosphorylation
T162 Phosphorylation
S164 Phosphorylation
T173 Phosphorylation

研究背景

機能:

It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks.

細胞の位置付け:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed in esophageal epithelial cells; expression is up-regulated after exposure to acidic bile acids.

タンパク質ファミリー:

Belongs to the glutathione peroxidase family.

研究領域

· Metabolism > Metabolism of other amino acids > Glutathione metabolism.

· Metabolism > Lipid metabolism > Arachidonic acid metabolism.

· Organismal Systems > Endocrine system > Thyroid hormone synthesis.

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