CKAP4 Antibody - #DF12190
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12190, RRID:AB_2844995.
折りたたみ／展開
63 kDa membrane protein; CKAP 4; Ckap4; CKAP4_HUMAN; Cytoskeleton associated protein 4; Cytoskeleton-associated protein 4; ERGIC 63; ERGIC63; MGC99554; p63; Transmembrane protein 63kD endoplasmic reticulum Golgi intermediate compartment; Type II transmembrane protein p63;
免疫原
- Q07065 CKAP4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPSAKQRGSKGGHGAASPSEKGAHPSGGADDVAKKPPPAPQQPPPPPAPHPQQHPQQHPQNQAHGKGGHRGGGGGGGKSSSSSSASAAAAAAAASSSASCSRRLGRALNFLFYLALVAAAAFSGWCVHHVLEEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDNIAIFTEVQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSREWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLKASVSQVEADLKMLRTAVDSLVAYSVKIETNENNLESAKGLLDDLRNDLDRLFVKVEKIHEKV
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q07065 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S3 | Phosphorylation | Uniprot | |
| S9 | Phosphorylation | Uniprot | |
| S17 | Phosphorylation | Uniprot | |
| S19 | Phosphorylation | Uniprot | |
| K21 | Ubiquitination | Uniprot | |
| S26 | Phosphorylation | Uniprot | |
| K78 | Ubiquitination | Uniprot | |
| C100 | S-Nitrosylation | Uniprot | |
| S101 | Phosphorylation | Uniprot | |
| S140 | Phosphorylation | Uniprot | |
| S145 | Phosphorylation | Uniprot | |
| K188 | Ubiquitination | Uniprot | |
| S195 | Phosphorylation | Uniprot | |
| S198 | Phosphorylation | Uniprot | |
| K206 | Ubiquitination | Uniprot | |
| K213 | Ubiquitination | Uniprot | |
| K223 | Ubiquitination | Uniprot | |
| T231 | Phosphorylation | Uniprot | |
| S232 | Phosphorylation | Uniprot | |
| T236 | Phosphorylation | Uniprot | |
| K270 | Acetylation | Uniprot | |
| K283 | Ubiquitination | Uniprot | |
| K287 | Ubiquitination | Uniprot | |
| K301 | Ubiquitination | Uniprot | |
| S312 | Phosphorylation | Uniprot | |
| T313 | Phosphorylation | Uniprot | |
| T316 | Phosphorylation | Uniprot | |
| Y322 | Phosphorylation | Uniprot | |
| T323 | Phosphorylation | Uniprot | |
| S330 | Phosphorylation | Uniprot | |
| K355 | Ubiquitination | Uniprot | |
| K405 | Ubiquitination | Uniprot | |
| S427 | Phosphorylation | Uniprot | |
| S436 | Phosphorylation | Uniprot | |
| S460 | Phosphorylation | Uniprot | |
| S461 | Phosphorylation | Uniprot | |
| K490 | Ubiquitination | Uniprot | |
| S492 | Phosphorylation | Uniprot | |
| T512 | O-Glycosylation | Uniprot | |
| S515 | Phosphorylation | Uniprot | |
| S534 | Phosphorylation | Uniprot | |
| S535 | Phosphorylation | Uniprot | |
| K540 | Ubiquitination | Uniprot | |
| K551 | Methylation | Uniprot | |
| K551 | Ubiquitination | Uniprot | |
| Y563 | Phosphorylation | Uniprot | |
| S576 | Phosphorylation | Uniprot | |
| K578 | Ubiquitination | Uniprot | |
| R590 | Methylation | Uniprot |
研究背景
High-affinity epithelial cell surface receptor for APF.
Mediates the anchoring of the endoplasmic reticulum to microtubules.
Reversibly palmitoylated. Palmitoylation at Cys-100 by DHHC2 is required for its trafficking from the ER to the plasma membrane and for its perinuclear localization.
Increased phosphorylation during mitosis prevents binding to microtubules.
Endoplasmic reticulum membrane>Single-pass type II membrane protein. Cell membrane>Single-pass type II membrane protein. Cytoplasm>Cytoskeleton. Cytoplasm>Perinuclear region.
Note: Translocates to the perinuclear region upon APF-stimulation.
研究領域
· Genetic Information Processing > Folding, sorting and degradation > Protein processing in endoplasmic reticulum. (View pathway)
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