LMNB2 Antibody - #DF12209
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12209, RRID:AB_2845014.
折りたたみ／展開
LAMB 2; LAMB2; Lamin-B2; LMN 2; LMN B2; LMN2; LMNB 2; LMNB2; LMNB2_HUMAN; MGC2721; RGD1563803;
免疫原
- Q03252 LMNB2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSPPSPGRRREQRRPRAAATMATPLPGRAGGPATPLSPTRLSRLQEKEELRELNDRLAHYIDRVRALELENDRLLLKISEKEEVTTREVSGIKALYESELADARRVLDETARERARLQIEIGKLRAELDEVNKSAKKREGELTVAQGRVKDLESLFHRSEVELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEELDFRKSVFEEEVRETRRRHERRLVEVDSSRQQEYDFKMAQALEELRSQHDEQVRLYKLELEQTYQAKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQLSGLQKQASAAEDRIRELEEAMAGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDVKLALDMEINAYRKLLEGEEERLKLSPSPSSRVTVSRATSSSSGSLSATGRLGRSKRKRLEVEEPLGSGPSVLGTGTGGSGGFHLAQQASASGSVSIEEIDLEGKFVQLKNNSDKDQSLGNWRIKRQVLEGEEIAYKFTPKYILRAGQMVTVWAAGAGVAHSPPSTLVWKGQSSWGTGESFRTVLVNADGEEVAMRTVKKSSVMRENENGEEEEEEAEFGEEDLFHQQGDPRTTSRGCYVM
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q03252 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T23 | Phosphorylation | Uniprot | |
| R28 | Methylation | Uniprot | |
| T34 | Phosphorylation | Uniprot | |
| S37 | Phosphorylation | P24941 (CDK2) | Uniprot |
| T39 | Phosphorylation | P24941 (CDK2) | Uniprot |
| S42 | Phosphorylation | Uniprot | |
| K47 | Acetylation | Uniprot | |
| K47 | Ubiquitination | Uniprot | |
| R56 | Methylation | Uniprot | |
| Y60 | Phosphorylation | Uniprot | |
| R73 | Methylation | Uniprot | |
| K77 | Acetylation | Uniprot | |
| K77 | Ubiquitination | Uniprot | |
| S79 | Phosphorylation | Uniprot | |
| K81 | Acetylation | Uniprot | |
| K81 | Ubiquitination | Uniprot | |
| K93 | Ubiquitination | Uniprot | |
| Y96 | Phosphorylation | Uniprot | |
| S98 | Phosphorylation | Uniprot | |
| K123 | Ubiquitination | Uniprot | |
| K133 | Ubiquitination | Uniprot | |
| S134 | Phosphorylation | Uniprot | |
| K150 | Acetylation | Uniprot | |
| K150 | Ubiquitination | Uniprot | |
| S154 | Phosphorylation | Uniprot | |
| S168 | Phosphorylation | Uniprot | |
| K170 | Acetylation | Uniprot | |
| K170 | Ubiquitination | Uniprot | |
| R171 | Methylation | Uniprot | |
| S175 | Phosphorylation | Uniprot | |
| K186 | Acetylation | Uniprot | |
| K186 | Ubiquitination | Uniprot | |
| K195 | Acetylation | Uniprot | |
| K200 | Acetylation | Uniprot | |
| K200 | Ubiquitination | Uniprot | |
| R211 | Methylation | Uniprot | |
| S214 | Phosphorylation | Uniprot | |
| K223 | Ubiquitination | Uniprot | |
| S224 | Phosphorylation | Uniprot | |
| S246 | Phosphorylation | Uniprot | |
| K255 | Ubiquitination | Uniprot | |
| R264 | Methylation | Uniprot | |
| S265 | Phosphorylation | Uniprot | |
| R272 | Methylation | Uniprot | |
| K275 | Ubiquitination | Uniprot | |
| Y282 | Phosphorylation | Uniprot | |
| K285 | Ubiquitination | Uniprot | |
| K290 | Acetylation | Uniprot | |
| K290 | Ubiquitination | Uniprot | |
| K298 | Acetylation | Uniprot | |
| K298 | Ubiquitination | Uniprot | |
| S301 | Phosphorylation | Uniprot | |
| K308 | Ubiquitination | Uniprot | |
| S316 | Phosphorylation | Uniprot | |
| S318 | Phosphorylation | Uniprot | |
| Y319 | Phosphorylation | Uniprot | |
| S322 | Phosphorylation | Uniprot | |
| K326 | Ubiquitination | Uniprot | |
| R334 | Methylation | Uniprot | |
| K351 | Ubiquitination | Uniprot | |
| Y374 | Phosphorylation | Uniprot | |
| K393 | Acetylation | Uniprot | |
| K393 | Sumoylation | Uniprot | |
| K393 | Ubiquitination | Uniprot | |
| R401 | Methylation | Uniprot | |
| K403 | Sumoylation | Uniprot | |
| K403 | Ubiquitination | Uniprot | |
| S405 | Phosphorylation | Uniprot | |
| S407 | Phosphorylation | Uniprot | |
| S409 | Phosphorylation | Uniprot | |
| S410 | Phosphorylation | Uniprot | |
| T413 | Phosphorylation | Uniprot | |
| S415 | Phosphorylation | Uniprot | |
| T418 | Phosphorylation | Uniprot | |
| S419 | Phosphorylation | Uniprot | |
| S420 | Phosphorylation | Uniprot | |
| S421 | Phosphorylation | Uniprot | |
| S422 | Phosphorylation | Uniprot | |
| S424 | Phosphorylation | Uniprot | |
| S426 | Phosphorylation | Uniprot | |
| T428 | Phosphorylation | Uniprot | |
| K489 | Ubiquitination | Uniprot | |
| S492 | Phosphorylation | Uniprot | |
| K494 | Ubiquitination | Uniprot | |
| S497 | Phosphorylation | Uniprot | |
| Y515 | Phosphorylation | Uniprot | |
| K516 | Ubiquitination | Uniprot | |
| T518 | Phosphorylation | Uniprot | |
| K520 | Acetylation | Uniprot | |
| K520 | Ubiquitination | Uniprot | |
| S541 | Phosphorylation | Uniprot | |
| S552 | Phosphorylation | Uniprot | |
| T556 | Phosphorylation | Uniprot | |
| S559 | Phosphorylation | Uniprot |
研究背景
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.
Nucleus inner membrane>Lipid-anchor>Nucleoplasmic side.
Interacts with TMEM43.
Belongs to the intermediate filament family.
研究領域
· Cellular Processes > Cell growth and death > Apoptosis. (View pathway)
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