PRPH2 Antibody - #DF12223
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12223, RRID:AB_2845028.
折りたたみ／展開
AOFMD; AVMD; CACD2; DS; Peripherin 2 (retinal degeneration, slow); Peripherin 2, homolog of mouse; Peripherin, photoreceptor type; Peripherin-2; PRPH; PRPH2; PRPH2_HUMAN; Rd2; RDS; Retinal degeneration slow protein; Retinal peripherin; RP7; Tetraspanin-22; Tspan-22; TSPAN22;
免疫原
- P23942 PRPH2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MALLKVKFDQKKRVKLAQGLWLMNWFSVLAGIIIFSLGLFLKIELRKRSDVMNNSESHFVPNSLIGMGVLSCVFNSLAGKICYDALDPAKYARWKPWLKPYLAICVLFNIILFLVALCCFLLRGSLENTLGQGLKNGMKYYRDTDTPGRCFMKKTIDMLQIEFKCCGNNGFRDWFEIQWISNRYLDFSSKEVKDRIKSNVDGRYLVDGVPFSCCNPSSPRPCIQYQITNNSAHYSYDHQTEELNLWVRGCRAALLSYYSSLMNSMGVVTLLIWLFEVTITIGLRYLQTSLDGVSNPEESESESEGWLLEKSVPETWKAFLESVKKLGKGNQVEAEGAGAGQAPEAG
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P23942 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y184 | Phosphorylation | Uniprot | |
| S189 | Phosphorylation | Uniprot |
研究背景
Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure (By similarity). Required for the maintenance of retinal outer nuclear layer thickness (By similarity). Required for the correct development and organization of the photoreceptor inner segment (By similarity).
Membrane>Multi-pass membrane protein. Cell projection>Cilium>Photoreceptor outer segment. Photoreceptor inner segment.
Retina (photoreceptor). In rim region of ROS (rod outer segment) disks.
Homodimer; disulfide-linked (By similarity). Forms a homotetramer (By similarity). Forms a heterotetramer with ROM1 (By similarity). Homotetramer and heterotetramer core complexes go on to form higher order complexes by formation of intermolecular disulfide bonds (By similarity). Interacts with MREG (By similarity). Interacts with STX3 (By similarity). Interacts with SNAP25 (By similarity).
Belongs to the PRPH2/ROM1 family.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.