SPTLC2 Antibody - #DF12231
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12231, RRID:AB_2845036.
折りたたみ／展開
KIAA0526; LCB 2; LCB2; LCB2a; Long chain base biosynthesis protein 2; Long chain base biosynthesis protein 2a; Serine palmitoyl CoA transferase 2; Serine palmitoyltransferase 2; Serine palmitoyltransferase long chain base subunit 2; Serine palmitoyltransferase subunit II; Serine-palmitoyl-CoA transferase 2; SPT 2; SPT2; SPTC2_HUMAN; SPTLC 2; Sptlc2;
免疫原
- O15270 SPTC2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQNGGLYKRPFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFENFYTRNLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGFATNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQPRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVVEYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQIITSMKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIGAFGREMLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKYSRHRLVPLLDRPFDETTYEETED
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O15270 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K161 | Ubiquitination | Uniprot | |
| Y176 | Phosphorylation | Uniprot | |
| Y178 | Phosphorylation | Uniprot | |
| K194 | Ubiquitination | Uniprot | |
| K215 | Ubiquitination | Uniprot | |
| K281 | Methylation | Uniprot | |
| K293 | Ubiquitination | Uniprot | |
| Y298 | Phosphorylation | Uniprot | |
| T303 | Phosphorylation | Uniprot | |
| S384 | Phosphorylation | Uniprot | |
| Y387 | Phosphorylation | Uniprot | |
| K391 | Ubiquitination | Uniprot | |
| K392 | Ubiquitination | Uniprot | |
| S402 | Phosphorylation | Uniprot | |
| T409 | Phosphorylation | Uniprot | |
| S412 | Phosphorylation | Uniprot | |
| T432 | Phosphorylation | Uniprot | |
| S433 | Phosphorylation | Uniprot | |
| K436 | Ubiquitination | Uniprot | |
| Y474 | Phosphorylation | Uniprot | |
| T501 | Phosphorylation | Uniprot | |
| K538 | Ubiquitination | Uniprot | |
| R550 | Methylation | Uniprot | |
| T555 | Phosphorylation | Uniprot | |
| Y557 | Phosphorylation | Uniprot | |
| T560 | Phosphorylation | Uniprot |
研究背景
Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate. Plays an important role in de novo sphyngolipid biosynthesis which is crucial for adipogenesis (By similarity).
Endoplasmic reticulum membrane>Single-pass membrane protein.
Widely expressed.
Heterodimer with SPTLC1. Component of the serine palmitoyltransferase (SPT) complex, composed of SPTLC1, either SPTLC2 or SPTLC3, and either SPTSSA or SPTSSB. The composition of the complex will define the substrate specificity.
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
研究領域
· Environmental Information Processing > Signal transduction > Sphingolipid signaling pathway. (View pathway)
· Metabolism > Lipid metabolism > Sphingolipid metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
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For Research Use Only.
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