SRP68 Antibody - #DF12232
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12232, RRID:AB_2845037.
折りたたみ／展開
Signal recognition particle 68; Signal recognition particle 68 kDa; Signal recognition particle 68 kDa protein; signal recognition particle 68kD; Signal recognition particle 68kDa; signal recognition particle subunit SRP68; SRP 68; SRP68; SRP68_HUMAN;
免疫原
- Q9UHB9 SRP68_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAEKQVPGGGGGGGSGGGGGSGGGGSGGGRGAGGEENKENERPSAGSKANKEFGDSLSLEILQIIKESQQQHGLRHGDFQRYRGYCSRRQRRLRKTLNFKMGNRHKFTGKKVTEELLTDNRYLLLVLMDAERAWSYAMQLKQEANTEPRKRFHLLSRLRKAVKHAEELERLCESNRVDAKTKLEAQAYTAYLSGMLRFEHQEWKAAIEAFNKCKTIYEKLASAFTEEQAVLYNQRVEEISPNIRYCAYNIGDQSAINELMQMRLRSGGTEGLLAEKLEALITQTRAKQAATMSEVEWRGRTVPVKIDKVRIFLLGLADNEAAIVQAESEETKERLFESMLSECRDAIQVVREELKPDQKQRDYILEGEPGKVSNLQYLHSYLTYIKLSTAIKRNENMAKGLQRALLQQQPEDDSKRSPRPQDLIRLYDIILQNLVELLQLPGLEEDKAFQKEIGLKTLVFKAYRCFFIAQSYVLVKKWSEALVLYDRVLKYANEVNSDAGAFKNSLKDLPDVQELITQVRSEKCSLQAAAILDANDAHQTETSSSQVKDNKPLVERFETFCLDPSLVTKQANLVHFPPGFQPIPCKPLFFDLALNHVAFPPLEDKLEQKTKSGLTGYIKGIFGFRS
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9UHB9 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K5 | Acetylation | Uniprot | |
| S16 | Phosphorylation | Uniprot | |
| S22 | Phosphorylation | Uniprot | |
| S27 | Phosphorylation | Uniprot | |
| R31 | Methylation | Uniprot | |
| K39 | Ubiquitination | Uniprot | |
| S48 | Phosphorylation | Uniprot | |
| K49 | Ubiquitination | Uniprot | |
| K52 | Ubiquitination | Uniprot | |
| K67 | Ubiquitination | Uniprot | |
| K112 | Ubiquitination | Uniprot | |
| K142 | Ubiquitination | Uniprot | |
| K164 | Ubiquitination | Uniprot | |
| K205 | Ubiquitination | Uniprot | |
| K220 | Ubiquitination | Uniprot | |
| S241 | Phosphorylation | Uniprot | |
| S267 | Phosphorylation | Uniprot | |
| T270 | Phosphorylation | Uniprot | |
| K277 | Ubiquitination | Uniprot | |
| K288 | Ubiquitination | Uniprot | |
| S294 | Phosphorylation | Uniprot | |
| K306 | Ubiquitination | Uniprot | |
| K333 | Ubiquitination | Uniprot | |
| S339 | Phosphorylation | Uniprot | |
| K360 | Ubiquitination | Uniprot | |
| Y364 | Phosphorylation | Uniprot | |
| K372 | Ubiquitination | Uniprot | |
| Y385 | Phosphorylation | Uniprot | |
| K400 | Ubiquitination | Uniprot | |
| K416 | Acetylation | Uniprot | |
| K416 | Ubiquitination | Uniprot | |
| K452 | Acetylation | Uniprot | |
| K452 | Ubiquitination | Uniprot | |
| K457 | Ubiquitination | Uniprot | |
| K491 | Ubiquitination | Uniprot | |
| K504 | Ubiquitination | Uniprot | |
| K508 | Ubiquitination | Uniprot | |
| T518 | Phosphorylation | Uniprot | |
| K524 | Ubiquitination | Uniprot | |
| T543 | Phosphorylation | Uniprot | |
| C562 | S-Nitrosylation | Uniprot | |
| T611 | Phosphorylation | Uniprot | |
| K612 | Ubiquitination | Uniprot | |
| Y618 | Phosphorylation | Uniprot | |
| S627 | Phosphorylation | Uniprot |
研究背景
Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function.
Cytoplasm. Nucleus>Nucleolus.
Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.
The RNA-binding domain is located near the N-terminus.
Belongs to the SRP68 family.
研究領域
· Genetic Information Processing > Folding, sorting and degradation > Protein export.
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