VPS37A Antibody - #DF12243
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12243, RRID:AB_2845048.
折りたたみ／展開
2210018P21Rik; 4930592A21Rik; AW261445; D8Ertd531e; ESCRT I complex subunit VPS37A; FLJ32642; FLJ42616; HCRP1; hepatocellular carcinoma related protein 1; hVps37A; MGC116266; polyglutamine binding protein 2; PQBP2; vacuolar protein sorting 37A; Vacuolar protein sorting associated protein 37A;
免疫原
Widely expressed. Examined tissues include heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. More abundant in liver. Strongly decreased or undetected in hepatomas.
- Q8NEZ2 VP37A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSWLFPLTKSASSSAAGSPGGLTSLQQQKQRLIESLRNSHSSIAEIQKDVEYRLPFTINNLTININILLPPQFPQEKPVISVYPPIRHHLMDKQGVYVTSPLVNNFTMHSDLGKIIQSLLDEFWKNPPVLAPTSTAFPYLYSNPSGMSPYASQGFPFLPPYPPQEANRSITSLSVADTVSSSTTSHTTAKPAAPSFGVLSNLPLPIPTVDASIPTSQNGFGYKMPDVPDAFPELSELSVSQLTDMNEQEEVLLEQFLTLPQLKQIITDKDDLVKSIEELARKNLLLEPSLEAKRQTVLDKYELLTQMKSTFEKKMQRQHELSESCSASALQARLKVAAHEAEEESDNIAEDFLEGKMEIDDFLSSFMEKRTICHCRRAKEEKLQQAIAMHSQFHAPL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q8NEZ2 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Phosphorylation | Uniprot | |
| T8 | Phosphorylation | Uniprot | |
| S13 | Phosphorylation | Uniprot | |
| S14 | Phosphorylation | Uniprot | |
| S18 | Phosphorylation | Uniprot | |
| K29 | Ubiquitination | Uniprot | |
| K269 | Ubiquitination | Uniprot | |
| K282 | Ubiquitination | Uniprot | |
| S289 | Phosphorylation | Uniprot | |
| K293 | Ubiquitination | Uniprot | |
| Y301 | Phosphorylation | Uniprot | |
| T310 | Phosphorylation | Uniprot | |
| K335 | Ubiquitination | Uniprot |
研究背景
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Late endosome membrane>Peripheral membrane protein. Nucleus.
Widely expressed. Examined tissues include heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. More abundant in liver. Strongly decreased or undetected in hepatomas.
Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry. Interacts with TSG101, VPS28 and HGS. Component of an ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, VPS37A and UBAP1 in a 1:1:1:1 stoichiometry.
Belongs to the VPS37 family.
研究領域
· Cellular Processes > Transport and catabolism > Endocytosis. (View pathway)
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