ALDH7A1 Antibody - #DF12247
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12247, RRID:AB_2845052.
折りたたみ／展開
26g turgor protein homolog; AL7A1_HUMAN; Aldehyde dehydrogenase 7 A1; Aldehyde dehydrogenase 7 family, member A1; Aldehyde dehydrogenase family 7 member A1; ALDH7A1; Alpha AASA dehydrogenase; Alpha aminoadipic semialdehyde dehydrogenase; Alpha-AASA dehydrogenase; Alpha-aminoadipic semialdehyde dehydrogenase; Antiquitin 1; Antiquitin; Antiquitin-1; ATQ1; Betaine aldehyde dehydrogenase; Delta1 piperideine 6 carboxylate dehydrogenease; Delta1-piperideine-6-carboxylate dehydrogenase; EPD; P6c dehydrogenase; PDE;
免疫原
Abundant in hepatoma cells and fetal cochlea, ovary, eye, heart, adrenal gland, liver and kidney. Low levels present in adult peripheral blood leukocytes and fetal brain, thymus, spleen, skeletal muscle, lung and tongue.
- P49419 AL7A1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MWRLPRALCVHAAKTSKLSGPWSRPAAFMSTLLINQPQYAWLKELGLREENEGVYNGSWGGRGEVITTYCPANNEPIARVRQASVADYEETVKKAREAWKIWADIPAPKRGEIVRQIGDALREKIQVLGSLVSLEMGKILVEGVGEVQEYVDICDYAVGLSRMIGGPILPSERSGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTINYSKDLPLAQGIKFQ
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P49419 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y39 | Phosphorylation | Uniprot | |
| Y69 | Phosphorylation | Uniprot | |
| S84 | Phosphorylation | Uniprot | |
| Y88 | Phosphorylation | Uniprot | |
| K93 | Acetylation | Uniprot | |
| K94 | Acetylation | Uniprot | |
| K109 | Ubiquitination | Uniprot | |
| S130 | Phosphorylation | Uniprot | |
| S133 | Phosphorylation | Uniprot | |
| S171 | Phosphorylation | Uniprot | |
| K352 | Ubiquitination | Uniprot | |
| S379 | Phosphorylation | Uniprot | |
| K389 | Acetylation | Uniprot | |
| K390 | Ubiquitination | Uniprot | |
| K439 | Acetylation | Uniprot | |
| K439 | Ubiquitination | Uniprot | |
| K452 | Ubiquitination | Uniprot | |
| S457 | Phosphorylation | Uniprot | |
| K500 | Ubiquitination | Uniprot | |
| C522 | S-Nitrosylation | Uniprot | |
| K528 | Acetylation | Uniprot | |
| K528 | Ubiquitination | Uniprot | |
| K537 | Ubiquitination | Uniprot |
研究背景
Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism.
Cytoplasm>Cytosol. Nucleus.
Mitochondrion.
Abundant in hepatoma cells and fetal cochlea, ovary, eye, heart, adrenal gland, liver and kidney. Low levels present in adult peripheral blood leukocytes and fetal brain, thymus, spleen, skeletal muscle, lung and tongue.
Homotetramer.
Belongs to the aldehyde dehydrogenase family.
研究領域
· Metabolism > Carbohydrate metabolism > Glycolysis / Gluconeogenesis.
· Metabolism > Carbohydrate metabolism > Ascorbate and aldarate metabolism.
· Metabolism > Lipid metabolism > Fatty acid degradation.
· Metabolism > Amino acid metabolism > Glycine, serine and threonine metabolism.
· Metabolism > Amino acid metabolism > Valine, leucine and isoleucine degradation.
· Metabolism > Amino acid metabolism > Lysine degradation.
· Metabolism > Amino acid metabolism > Arginine and proline metabolism.
· Metabolism > Amino acid metabolism > Histidine metabolism.
· Metabolism > Amino acid metabolism > Tryptophan metabolism.
· Metabolism > Metabolism of other amino acids > beta-Alanine metabolism.
· Metabolism > Lipid metabolism > Glycerolipid metabolism.
· Metabolism > Carbohydrate metabolism > Pyruvate metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.