HERP Antibody - #DF12278
| 製品: | HERP Antibody |
| カタログ: | DF12278 |
| タンパク質の説明: | Rabbit polyclonal antibody to HERP |
| アプリケーション: | WB IHC |
| 反応性: | Human |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 52 kDa; 44kD(Calculated). |
| ユニプロット: | Q15011 |
| RRID: | AB_2845083 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12278, RRID:AB_2845083.
折りたたみ／展開
HERP; HERP1_HUMAN; HERPUD1; Homocysteine inducible endoplasmic reticulum stress inducible ubiquitin like domain member 1; Homocysteine inducible endoplasmic reticulum stress inducible ubiquitin like domain member 1 protein; Homocysteine responsive endoplasmic reticulum resident ubiquitin like domain member 1; Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein; KIAA0025; Methyl methanesulfonate (MMF) inducible fragment protein 1; Methyl methanesulfonate (MMF)-inducible fragment protein 1; MIF1; MMS inducible; SUP;
免疫原
Widely expressed; in the brain, expression seems to be restricted to neurons and vascular smooth muscle cells. Present in activated microglia in senile plaques in the brain of patients with Alzheimer disease.
- Q15011 HERP1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MESETEPEPVTLLVKSPNQRHRDLELSGDRGWSVGHLKAHLSRVYPERPRPEDQRLIYSGKLLLDHQCLRDLLPKQEKRHVLHLVCNVKSPSKMPEINAKVAESTEEPAGSNRGQYPEDSSSDGLRQREVLRNLSSPGWENISRPEAAQQAFQGLGPGFSGYTPYGWLQLSWFQQIYARQYYMQYLAATAASGAFVPPPSAQEIPVVSAPAPAPIHNQFPAENQPANQNAAPQVVVNPGANQNLRMNAQGGPIVEEDDEINRDWLDWTYSAATFSVFLSILYFYSSLSRFLMVMGATVVMYLHHVGWFPFRPRPVQNFPNDGPPPDVVNQDPNNNLQEGTDPETEDPNHLPPDRDVLDGEQTSPSFMSTAWLVFKTFFASLLPEGPPAIAN
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q15011 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| S3 | Phosphorylation | Uniprot | |
| K38 | Ubiquitination | Uniprot | |
| S59 | Phosphorylation | Uniprot | |
| K61 | Ubiquitination | Uniprot | |
| K75 | Ubiquitination | Uniprot | |
| K89 | Acetylation | Uniprot | |
| K89 | Ubiquitination | Uniprot | |
| S90 | Phosphorylation | Uniprot | |
| K93 | Ubiquitination | Uniprot | |
| K100 | Ubiquitination | Uniprot | |
| S135 | Phosphorylation | Uniprot | |
| K375 | Ubiquitination | Uniprot |
研究背景
Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway.
Endoplasmic reticulum membrane>Multi-pass membrane protein.
Widely expressed; in the brain, expression seems to be restricted to neurons and vascular smooth muscle cells. Present in activated microglia in senile plaques in the brain of patients with Alzheimer disease.
Interacts with PSEN1 and PSEN2. Interacts with SYVN1 and UBXN6. Interacts with UBQLN1, UBQLN2 and UBQLN4.
研究領域
· Genetic Information Processing > Folding, sorting and degradation > Protein processing in endoplasmic reticulum. (View pathway)
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