製品: Peroxiredoxin 5 Antibody
カタログ: DF12307
タンパク質の説明: Rabbit polyclonal antibody to Peroxiredoxin 5
アプリケーション: WB IHC IF/ICC
反応性: Human, Mouse, Rat
予測: Pig, Zebrafish, Bovine, Horse, Sheep, Xenopus
分子量: 17 kDa; 22kD(Calculated).
ユニプロット: P30044
RRID: AB_2845112

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Pig(91%), Zebrafish(90%), Bovine(91%), Horse(91%), Sheep(91%), Xenopus(82%)
クローナリティ:
Polyclonal
特異性:
Peroxiredoxin 5 Antibody detects endogenous levels of total Peroxiredoxin 5.
RRID:
AB_2845112
引用形式: Affinity Biosciences Cat# DF12307, RRID:AB_2845112.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

ACR1; Alu co repressor 1; Alu corepressor 1; Antioxidant enzyme B166; AOEB166; B166; epididymis secretory protein Li 55; HEL-S-55; Liver tissue 2D-page spot 71B; mitochondrial; Peroxiredoxin 5, mitochondrial; Peroxiredoxin V; Peroxiredoxin-5; Peroxisomal antioxidant enzyme; PLP; PMP20; PRDX 5; PRDX5; PRDX5_HUMAN; PRDX6; Prx-V; PRXV; SBBI10; Thioredoxin peroxidase PMP20; Thioredoxin reductase; TPx type VI;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
発現特異性:
P30044 PRDX5_HUMAN:

Widely expressed.

タンパク質配列:
MGLAGVCALRRSAGYILVGGAGGQSAAAAARRYSEGEWASGGVRSFSRAAAAMAPIKVGDAIPAVEVFEGEPGNKVNLAELFKGKKGVLFGVPGAFTPGCSKTHLPGFVEQAEALKAKGVQVVACLSVNDAFVTGEWGRAHKAEGKVRLLADPTGAFGKETDLLLDDSLVSIFGNRRLKRFSMVVQDGIVKALNVEPDGTGLTCSLAPNIISQL

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
91
Horse
91
Bovine
91
Sheep
91
Zebrafish
90
Xenopus
82
Dog
0
Chicken
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P30044 基板として

Site PTM Type Enzyme
S34 Phosphorylation
K75 Ubiquitination
K83 Acetylation
K83 Ubiquitination
K86 Ubiquitination
T97 Phosphorylation
C100 S-Nitrosylation
S101 Phosphorylation
K102 Ubiquitination
K116 Ubiquitination
K118 Ubiquitination
K146 Ubiquitination
K159 Ubiquitination
S182 Phosphorylation

研究背景

機能:

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.

細胞の位置付け:

Mitochondrion.

Cytoplasm. Peroxisome matrix.
Note: Imported into peroxisomes via peroxisomal targeting signal 1 receptor PEX5.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Widely expressed.

サブユニット構造:

Monomer.

タンパク質ファミリー:

Belongs to the peroxiredoxin family. Prx5 subfamily.

研究領域

· Cellular Processes > Transport and catabolism > Peroxisome.   (View pathway)

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