PYGB Antibody - #DF12308
| 製品: | PYGB Antibody |
| カタログ: | DF12308 |
| タンパク質の説明: | Rabbit polyclonal antibody to PYGB |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 97 kDa; 97kD(Calculated). |
| ユニプロット: | P11216 |
| RRID: | AB_2845113 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12308, RRID:AB_2845113.
折りたたみ／展開
Brain glycogen phosphorylase; Glycogen phosphorylase B; Glycogen phosphorylase brain form; Glycogen Phosphorylase Isoenzyme BB; Glycogen phosphorylase, brain form; MGC9213; Phosphorylase glycogen brain; PYGB; PYGB_HUMAN;
免疫原
- P11216 PYGB_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAKPLTDSEKRKQISVRGLAGLGDVAEVRKSFNRHLHFTLVKDRNVATPRDYFFALAHTVRDHLVGRWIRTQQHYYERDPKRIYYLSLEFYMGRTLQNTMVNLGLQNACDEAIYQLGLDLEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKIVNGWQVEEADDWLRYGNPWEKARPEYMLPVHFYGRVEHTPDGVKWLDTQVVLAMPYDTPVPGYKNNTVNTMRLWSAKAPNDFKLQDFNVGDYIEAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRTCFETFPDKVAIQLNDTHPALSIPELMRILVDVEKVDWDKAWEITKKTCAYTNHTVLPEALERWPVSMFEKLLPRHLEIIYAINQRHLDHVAALFPGDVDRLRRMSVIEEGDCKRINMAHLCVIGSHAVNGVARIHSEIVKQSVFKDFYELEPEKFQNKTNGITPRRWLLLCNPGLADTIVEKIGEEFLTDLSQLKKLLPLVSDEVFIRDVAKVKQENKLKFSAFLEKEYKVKINPSSMFDVHVKRIHEYKRQLLNCLHVVTLYNRIKRDPAKAFVPRTVMIGGKAAPGYHMAKLIIKLVTSIGDVVNHDPVVGDRLKVIFLENYRVSLAEKVIPAADLSQQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGAENLFIFGLRVEDVEALDRKGYNAREYYDHLPELKQAVDQISSGFFSPKEPDCFKDIVNMLMHHDRFKVFADYEAYMQCQAQVDQLYRNPKEWTKKVIRNIACSGKFSSDRTITEYAREIWGVEPSDLQIPPPNIPRD
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P11216 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| K3 | Acetylation | Uniprot | |
| K3 | Ubiquitination | Uniprot | |
| T6 | Phosphorylation | Uniprot | |
| S8 | Phosphorylation | Uniprot | |
| K10 | Acetylation | Uniprot | |
| K10 | Ubiquitination | Uniprot | |
| S15 | Phosphorylation | Q8IWU2 (LMTK2) | Uniprot |
| S31 | Phosphorylation | Uniprot | |
| T39 | Phosphorylation | Uniprot | |
| K42 | Ubiquitination | Uniprot | |
| Y52 | Phosphorylation | Uniprot | |
| Y75 | Phosphorylation | Uniprot | |
| Y76 | Phosphorylation | Uniprot | |
| Y84 | Phosphorylation | Uniprot | |
| Y85 | Phosphorylation | Uniprot | |
| S87 | Phosphorylation | Uniprot | |
| Y91 | Phosphorylation | Uniprot | |
| Y162 | Phosphorylation | Uniprot | |
| Y186 | Phosphorylation | Uniprot | |
| K192 | Ubiquitination | Uniprot | |
| Y197 | Phosphorylation | Uniprot | |
| Y204 | Phosphorylation | Uniprot | |
| T210 | Phosphorylation | Uniprot | |
| Y227 | Phosphorylation | Uniprot | |
| T229 | Phosphorylation | Uniprot | |
| K235 | Ubiquitination | Uniprot | |
| T241 | Phosphorylation | Uniprot | |
| K248 | Ubiquitination | Uniprot | |
| K254 | Ubiquitination | Uniprot | |
| Y263 | Phosphorylation | Uniprot | |
| Y281 | Phosphorylation | Uniprot | |
| K290 | Ubiquitination | Uniprot | |
| K295 | Ubiquitination | Uniprot | |
| K316 | Acetylation | Uniprot | |
| C326 | S-Nitrosylation | Uniprot | |
| K359 | Ubiquitination | Uniprot | |
| K364 | Ubiquitination | Uniprot | |
| K371 | Ubiquitination | Uniprot | |
| T372 | Phosphorylation | Uniprot | |
| K395 | Ubiquitination | Uniprot | |
| Y405 | Phosphorylation | Uniprot | |
| S430 | Phosphorylation | Uniprot | |
| K438 | Ubiquitination | Uniprot | |
| K465 | Ubiquitination | Uniprot | |
| K470 | Ubiquitination | Uniprot | |
| Y473 | Phosphorylation | Uniprot | |
| K479 | Ubiquitination | Uniprot | |
| K483 | Ubiquitination | Uniprot | |
| K520 | Ubiquitination | Uniprot | |
| K521 | Ubiquitination | Uniprot | |
| S527 | Phosphorylation | Uniprot | |
| K545 | Ubiquitination | Uniprot | |
| K552 | Ubiquitination | Uniprot | |
| Y554 | Phosphorylation | Uniprot | |
| K557 | Ubiquitination | Uniprot | |
| S562 | Phosphorylation | Uniprot | |
| K597 | Ubiquitination | Uniprot | |
| K609 | Ubiquitination | Uniprot | |
| K642 | Ubiquitination | Uniprot | |
| K656 | Ubiquitination | Uniprot | |
| Y727 | Phosphorylation | Uniprot | |
| Y732 | Phosphorylation | Uniprot | |
| Y733 | Phosphorylation | Uniprot | |
| K740 | Ubiquitination | Uniprot | |
| S752 | Phosphorylation | Uniprot | |
| K754 | Ubiquitination | Uniprot | |
| K796 | Acetylation | Uniprot | |
| K796 | Ubiquitination | Uniprot | |
| K811 | Acetylation | Uniprot | |
| K811 | Ubiquitination | Uniprot |
研究背景
Glycogen phosphorylase that regulates glycogen mobilization. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
Phosphorylated. Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A (By similarity).
Homodimer. Dimers associate into a tetramer to form the enzymatically active phosphorylase A.
Belongs to the glycogen phosphorylase family.
研究領域
· Cellular Processes > Cell growth and death > Necroptosis. (View pathway)
· Human Diseases > Endocrine and metabolic diseases > Insulin resistance.
· Metabolism > Carbohydrate metabolism > Starch and sucrose metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Organismal Systems > Endocrine system > Insulin signaling pathway. (View pathway)
· Organismal Systems > Endocrine system > Glucagon signaling pathway.
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