Secretogranin III Antibody - #DF12316
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12316, RRID:AB_2845121.
折りたたみ／展開
1B1075; AI385542; Chgd; SCG3; SCG3_HUMAN; Secretogranin III; Secretogranin-3; SGCG; SgIII;
免疫原
- Q8WXD2 SCG3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGFLGTGTWILVLVLPIQAFPKPGGSQDKSLHNRELSAERPLNEQIAEAEEDKIKKTYPPENKPGQSNYSFVDNLNLLKAITEKEKIEKERQSIRSSPLDNKLNVEDVDSTKNRKLIDDYDSTKSGLDHKFQDDPDGLHQLDGTPLTAEDIVHKIAARIYEENDRAVFDKIVSKLLNLGLITESQAHTLEDEVAEVLQKLISKEANNYEEDPNKPTSWTENQAGKIPEKVTPMAAIQDGLAKGENDETVSNTLTLTNGLERRTKTYSEDNFEELQYFPNFYALLKSIDSEKEAKEKETLITIMKTLIDFVKMMVKYGTISPEEGVSYLENLDEMIALQTKNKLEKNATDNISKLFPAPSEKSHEETDSTKEEAAKMEKEYGSLKDSTKDDNSNPGGKTDEPKGKTEAYLEAIRKNIEWLKKHDKKGNKEDYDLSKMRDFINKQADAYVEKGILDKEEAEAIKRIYSSL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q8WXD2 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S37 | Phosphorylation | Uniprot | |
| T144 | O-Glycosylation | Uniprot | |
| Y208 | Phosphorylation | Uniprot | |
| T216 | O-Glycosylation | Uniprot | |
| T231 | O-Glycosylation | Uniprot | |
| K294 | Ubiquitination | Uniprot | |
| T301 | Phosphorylation | Uniprot | |
| S320 | Phosphorylation | Uniprot | |
| S359 | O-Glycosylation | Uniprot | |
| S362 | Phosphorylation | Uniprot | |
| S386 | Phosphorylation | Uniprot | |
| K397 | Acetylation | Uniprot |
研究背景
Member of the granin protein family that regulates the biogenesis of secretory granules. Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA (By similarity). May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway.
O-glycosylated.
Cytoplasmic vesicle>Secretory vesicle. Cytoplasmic vesicle>Secretory vesicle membrane>Peripheral membrane protein. Secreted.
Note: Associated with the secretory granule membrane through direct binding to cholesterol-enriched lipid rafts.
Expressed in brain, heart, kidney, liver and skeletal muscle.
Interacts with CHGA (By similarity). Interacts with secretogranin II/SCG2. Interacts (via C-terminus) with CPE (By similarity).
Restrictive clause
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