Syndecan-3 Antibody - #DF12329
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12329, RRID:AB_2845134.
折りたたみ／展開
N-syndecan; Sdc3; SDC3_HUMAN; SDCN; SYND3; Syndecan neural type; syndecan proteoglycan 3; Syndecan-3;
免疫原
- O75056 SDC3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKPGPPHRAGAAHGAGAGAGAAAGPGARGLLLPPLLLLLLAGRAAGAQRWRSENFERPVDLEGSGDDDSFPDDELDDLYSGSGSGYFEQESGIETAMRFSPDVALAVSTTPAVLPTTNIQPVGTPFEELPSERPTLEPATSPLVVTEVPEEPSQRATTVSTTMATTAATSTGDPTVATVPATVATATPSTPAAPPFTATTAVIRTTGVRRLLPLPLTTVATARATTPEAPSPPTTAAVLDTEAPTPRLVSTATSRPRALPRPATTQEPDIPERSTLPLGTTAPGPTEVAQTPTPETFLTTIRDEPEVPVSGGPSGDFELPEEETTQPDTANEVVAVGGAAAKASSPPGTLPKGARPGPGLLDNAIDSGSSAAQLPQKSILERKEVLVAVIVGGVVGALFAAFLVTLLIYRMKKKDEGSYTLEEPKQASVTYQKPDKQEEFYA
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O75056 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T146 | Phosphorylation | Uniprot | |
| T234 | Phosphorylation | Uniprot | |
| T245 | Phosphorylation | Uniprot | |
| S250 | O-Glycosylation | Uniprot | |
| T251 | O-Glycosylation | Uniprot | |
| T253 | O-Glycosylation | Uniprot | |
| T264 | O-Glycosylation | Uniprot | |
| T265 | O-Glycosylation | Uniprot | |
| S344 | O-Glycosylation | Uniprot | |
| T349 | O-Glycosylation | Uniprot | |
| T349 | Phosphorylation | Uniprot | |
| Y409 | Phosphorylation | P54760 (EPHB4) | Uniprot |
| K414 | Ubiquitination | Uniprot | |
| S418 | Phosphorylation | Uniprot | |
| Y419 | Phosphorylation | P54760 (EPHB4) | Uniprot |
| S428 | Phosphorylation | Uniprot | |
| Y431 | Phosphorylation | P54760 (EPHB4) | Uniprot |
| K433 | Ubiquitination | Uniprot | |
| K436 | Ubiquitination | Uniprot | |
| Y441 | Phosphorylation | Uniprot |
研究背景
Cell surface proteoglycan that may bear heparan sulfate (By similarity). May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism.
O-glycosylated within the Thr/Ser-rich region which could interact with lectin domains on other molecules.
Cell membrane>Single-pass type I membrane protein.
Expressed in the nervous system, the adrenal gland, and the spleen.
Interacts with TIAM1. Interacts with PTN (via heparan sulfate chains); this interaction mediates the neurite outgrowth-promoting signal from PTN to the cytoskeleton of growing neurites; this interaction mediates osteoblast recruitment (By similarity). Interacts with MDK; this interaction induces SDC3 clustering; this interaction induces neuronal cell adhesion and neurite outgrowth (By similarity).
Belongs to the syndecan proteoglycan family.
研究領域
· Environmental Information Processing > Signaling molecules and interaction > Cell adhesion molecules (CAMs). (View pathway)
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