ATP6V1A Antibody - #DF12353
| 製品: | ATP6V1A Antibody |
| カタログ: | DF12353 |
| タンパク質の説明: | Rabbit polyclonal antibody to ATP6V1A |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Dog, Chicken, Xenopus |
| 分子量: | 68 kDa; 68kD(Calculated). |
| ユニプロット: | P38606 |
| RRID: | AB_2845158 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12353, RRID:AB_2845158.
折りたたみ／展開
70kDa subunit; ATP6A1; ATP6V1A; ATP6V1A1; ATPase H+ transporting lysosomal subunit A1; ATPase H+ transporting, lysosomal 70kDa V1 subunit A; H(+) transporting two sector ATPase subunit A; H+ transporting ATPase chain A vacuolar (VA68 type); HO68; OTTHUMP00000214746; V ATPase 69 kDa subunit 1; V ATPase A subunit 1; V ATPase subunit A 1; V-ATPase 69 kDa subunit; V-ATPase subunit A; V-type proton ATPase catalytic subunit A; VA68; Vacuolar ATP synthase catalytic subunit A ubiquitous isoform; Vacuolar ATPase isoform VA68; Vacuolar proton pump alpha subunit 1; Vacuolar proton pump subunit alpha; VATA_HUMAN; Vma1; VPP2;
免疫原
- P38606 VATA_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDFSKLPKILDEDKESTFGYVHGVSGPVVTACDMAGAAMYELVRVGHSELVGEIIRLEGDMATIQVYEETSGVSVGDPVLRTGKPLSVELGPGIMGAIFDGIQRPLSDISSQTQSIYIPRGVNVSALSRDIKWDFTPCKNLRVGSHITGGDIYGIVSENSLIKHKIMLPPRNRGTVTYIAPPGNYDTSDVVLELEFEGVKEKFTMVQVWPVRQVRPVTEKLPANHPLLTGQRVLDALFPCVQGGTTAIPGAFGCGKTVISQSLSKYSNSDVIIYVGCGERGNEMSEVLRDFPELTMEVDGKVESIMKRTALVANTSNMPVAAREASIYTGITLSEYFRDMGYHVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERAGRVKCLGNPEREGSVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSVNWLISYSKYMRALDEYYDKHFTEFVPLRTKAKEILQEEEDLAEIVQLVGKASLAETDKITLEVAKLIKDDFLQQNGYTPYDRFCPFYKTVGMLSNMIAFYDMARRAVETTAQSDNKITWSIIREHMGDILYKLSSMKFKDPLKDGEAKIKSDYAQLLEDMQNAFRSLED
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P38606 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K5 | Ubiquitination | Uniprot | |
| K8 | Ubiquitination | Uniprot | |
| K84 | Ubiquitination | Uniprot | |
| Y117 | Phosphorylation | Uniprot | |
| S125 | Phosphorylation | Uniprot | |
| K132 | Ubiquitination | Uniprot | |
| T136 | Phosphorylation | Uniprot | |
| K139 | Ubiquitination | Uniprot | |
| S145 | Phosphorylation | Uniprot | |
| T148 | Phosphorylation | Uniprot | |
| Y153 | Phosphorylation | Uniprot | |
| S160 | Phosphorylation | Uniprot | |
| K163 | Ubiquitination | Uniprot | |
| K165 | Ubiquitination | Uniprot | |
| T175 | Phosphorylation | Uniprot | |
| K220 | Ubiquitination | Uniprot | |
| K256 | Ubiquitination | Uniprot | |
| K265 | Methylation | Uniprot | |
| K265 | Ubiquitination | Uniprot | |
| K307 | Ubiquitination | Uniprot | |
| T309 | Phosphorylation | Uniprot | |
| S316 | Phosphorylation | Uniprot | |
| R364 | Methylation | Uniprot | |
| R381 | Methylation | Uniprot | |
| S384 | Phosphorylation | Uniprot | |
| K393 | Ubiquitination | Uniprot | |
| Y454 | Phosphorylation | Uniprot | |
| Y457 | Phosphorylation | Uniprot | |
| Y464 | Phosphorylation | Uniprot | |
| Y465 | Phosphorylation | Uniprot | |
| K467 | Acetylation | Uniprot | |
| K467 | Ubiquitination | Uniprot | |
| K480 | Ubiquitination | Uniprot | |
| K498 | Ubiquitination | Uniprot | |
| K506 | Ubiquitination | Uniprot | |
| K513 | Ubiquitination | Uniprot | |
| K516 | Ubiquitination | Uniprot | |
| Y528 | Phosphorylation | Uniprot | |
| R530 | Methylation | Uniprot | |
| K564 | Ubiquitination | Uniprot | |
| Y579 | Phosphorylation | Uniprot | |
| K580 | Acetylation | Uniprot | |
| K580 | Ubiquitination | Uniprot | |
| K585 | Ubiquitination | Uniprot | |
| K587 | Ubiquitination | Uniprot | |
| K591 | Ubiquitination | Uniprot | |
| K596 | Acetylation | Uniprot | |
| K598 | Ubiquitination | Uniprot | |
| S599 | Phosphorylation | Uniprot | |
| Y601 | Phosphorylation | Uniprot | |
| S614 | Phosphorylation | Uniprot |
研究背景
Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. May play a role in neurite development and synaptic connectivity.
Cytoplasm.
High expression in the skin.
V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (main components: subunits A, B, C, D, E, and F) attached to an integral membrane V0 proton pore complex (main component: the proteolipid protein).
Belongs to the ATPase alpha/beta chains family.
研究領域
· Cellular Processes > Transport and catabolism > Phagosome. (View pathway)
· Environmental Information Processing > Signal transduction > mTOR signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Bacterial > Vibrio cholerae infection.
· Human Diseases > Infectious diseases: Bacterial > Epithelial cell signaling in Helicobacter pylori infection.
· Human Diseases > Immune diseases > Rheumatoid arthritis.
· Metabolism > Energy metabolism > Oxidative phosphorylation.
· Metabolism > Global and overview maps > Metabolic pathways.
· Organismal Systems > Nervous system > Synaptic vesicle cycle.
· Organismal Systems > Excretory system > Collecting duct acid secretion.
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