LRPPRC Antibody - #DF12421
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12421, RRID:AB_2845226.
折りたたみ／展開
130 kDa leucine-rich protein; gp130; Leucine-rich PPR motif-containing protein; Leucine-rich PPR-motif containing protein; LPPRC_HUMAN; LRP 130; lrpprc; mitochondrial;
免疫原
Expressed ubiquitously. Expression is highest in heart, skeletal muscle, kidney and liver, intermediate in brain, non-mucosal colon, spleen and placenta, and lowest in small intestine, thymus, lung and peripheral blood leukocytes.
- P42704 LPPRC_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAALLRSARWLLRAGAAPRLPLSLRLLPGGPGRLHAASYLPAARAGPVAGGLLSPARLYAIAAKEKDIQEESTFSSRKISNQFDWALMRLDLSVRRTGRIPKKLLQKVFNDTCRSGGLGGSHALLLLRSCGSLLPELKLEERTEFAHRIWDTLQKLGAVYDVSHYNALLKVYLQNEYKFSPTDFLAKMEEANIQPNRVTYQRLIASYCNVGDIEGASKILGFMKTKDLPVTEAVFSALVTGHARAGDMENAENILTVMRDAGIEPGPDTYLALLNAYAEKGDIDHVKQTLEKVEKSELHLMDRDLLQIIFSFSKAGYPQYVSEILEKVTCERRYIPDAMNLILLLVTEKLEDVALQILLACPVSKEDGPSVFGSFFLQHCVTMNTPVEKLTDYCKKLKEVQMHSFPLQFTLHCALLANKTDLAKALMKAVKEEGFPIRPHYFWPLLVGRRKEKNVQGIIEILKGMQELGVHPDQETYTDYVIPCFDSVNSARAILQENGCLSDSDMFSQAGLRSEAANGNLDFVLSFLKSNTLPISLQSIRSSLLLGFRRSMNINLWSEITELLYKDGRYCQEPRGPTEAVGYFLYNLIDSMSDSEVQAKEEHLRQYFHQLEKMNVKIPENIYRGIRNLLESYHVPELIKDAHLLVESKNLDFQKTVQLTSSELESTLETLKAENQPIRDVLKQLILVLCSEENMQKALELKAKYESDMVTGGYAALINLCCRHDKVEDALNLKEEFDRLDSSAVLDTGKYVGLVRVLAKHGKLQDAINILKEMKEKDVLIKDTTALSFFHMLNGAALRGEIETVKQLHEAIVTLGLAEPSTNISFPLVTVHLEKGDLSTALEVAIDCYEKYKVLPRIHDVLCKLVEKGETDLIQKAMDFVSQEQGEMVMLYDLFFAFLQTGNYKEAKKIIETPGIRARSARLQWFCDRCVANNQVETLEKLVELTQKLFECDRDQMYYNLLKLYKINGDWQRADAVWNKIQEENVIPREKTLRLLAEILREGNQEVPFDVPELWYEDEKHSLNSSSASTTEPDFQKDILIACRLNQKKGAYDIFLNAKEQNIVFNAETYSNLIKLLMSEDYFTQAMEVKAFAETHIKGFTLNDAANSRLIITQVRRDYLKEAVTTLKTVLDQQQTPSRLAVTRVIQALAMKGDVENIEVVQKMLNGLEDSIGLSKMVFINNIALAQIKNNNIDAAIENIENMLTSENKVIEPQYFGLAYLFRKVIEEQLEPAVEKISIMAERLANQFAIYKPVTDFFLQLVDAGKVDDARALLQRCGAIAEQTPILLLFLLRNSRKQGKASTVKSVLELIPELNEKEEAYNSLMKSYVSEKDVTSAKALYEHLTAKNTKLDDLFLKRYASLLKYAGEPVPFIEPPESFEFYAQQLRKLRENSS
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P42704 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S23 | Phosphorylation | Uniprot | |
| S54 | Phosphorylation | Uniprot | |
| S75 | Phosphorylation | Uniprot | |
| S80 | Phosphorylation | Uniprot | |
| K107 | Acetylation | Uniprot | |
| K107 | Ubiquitination | Uniprot | |
| R128 | Methylation | Uniprot | |
| C130 | S-Nitrosylation | Uniprot | |
| K138 | Acetylation | Uniprot | |
| K155 | Acetylation | Uniprot | |
| K155 | Ubiquitination | Uniprot | |
| Y160 | Phosphorylation | Uniprot | |
| Y165 | Phosphorylation | Uniprot | |
| S180 | Phosphorylation | Uniprot | |
| K187 | Acetylation | Uniprot | |
| R197 | Methylation | Uniprot | |
| Y207 | Phosphorylation | Uniprot | |
| S236 | Phosphorylation | Uniprot | |
| T269 | Phosphorylation | Uniprot | |
| Y270 | Phosphorylation | Uniprot | |
| Y277 | Phosphorylation | Uniprot | |
| K280 | Ubiquitination | Uniprot | |
| K287 | Ubiquitination | Uniprot | |
| K292 | Acetylation | Uniprot | |
| Y320 | Phosphorylation | Uniprot | |
| Y334 | Phosphorylation | Uniprot | |
| K396 | Acetylation | Uniprot | |
| K453 | Ubiquitination | Uniprot | |
| S536 | Phosphorylation | Uniprot | |
| S543 | Phosphorylation | Uniprot | |
| S593 | Phosphorylation | Uniprot | |
| R605 | Methylation | Uniprot | |
| Y607 | Phosphorylation | Uniprot | |
| K613 | Acetylation | Uniprot | |
| K613 | Ubiquitination | Uniprot | |
| K617 | Sumoylation | Uniprot | |
| K617 | Ubiquitination | Uniprot | |
| Y623 | Phosphorylation | Uniprot | |
| Y633 | Phosphorylation | Uniprot | |
| K649 | Acetylation | Uniprot | |
| K649 | Ubiquitination | Uniprot | |
| K655 | Ubiquitination | Uniprot | |
| T660 | Phosphorylation | Uniprot | |
| S661 | Phosphorylation | Uniprot | |
| S662 | Phosphorylation | Uniprot | |
| S666 | Phosphorylation | Uniprot | |
| K726 | Acetylation | Uniprot | |
| R739 | Methylation | Uniprot | |
| S742 | Phosphorylation | Uniprot | |
| K750 | Acetylation | Uniprot | |
| K777 | Acetylation | Uniprot | |
| K851 | Acetylation | Uniprot | |
| K864 | Acetylation | Uniprot | |
| K868 | Acetylation | Uniprot | |
| S882 | Phosphorylation | Uniprot | |
| N903 | Phosphorylation | Uniprot | |
| T913 | Phosphorylation | Uniprot | |
| S920 | Phosphorylation | Uniprot | |
| R929 | Methylation | Uniprot | |
| C930 | S-Nitrosylation | Uniprot | |
| Y958 | Phosphorylation | Uniprot | |
| K980 | Ubiquitination | Uniprot | |
| Y1016 | Phosphorylation | Uniprot | |
| S1022 | Phosphorylation | Uniprot | |
| S1025 | Phosphorylation | Uniprot | |
| S1026 | Phosphorylation | Uniprot | |
| S1029 | Phosphorylation | Uniprot | |
| T1031 | Phosphorylation | Uniprot | |
| Y1052 | Phosphorylation | Uniprot | |
| Y1070 | Phosphorylation | Uniprot | |
| Y1082 | Phosphorylation | Uniprot | |
| T1084 | Phosphorylation | Uniprot | |
| K1098 | Ubiquitination | Uniprot | |
| T1136 | Phosphorylation | Uniprot | |
| S1138 | Phosphorylation | Uniprot | |
| K1163 | Ubiquitination | Uniprot | |
| S1171 | Phosphorylation | Uniprot | |
| S1175 | Phosphorylation | Uniprot | |
| Y1215 | Phosphorylation | Uniprot | |
| Y1220 | Phosphorylation | Uniprot | |
| K1224 | Acetylation | Uniprot | |
| Y1251 | Phosphorylation | Uniprot | |
| C1277 | S-Nitrosylation | Uniprot | |
| S1306 | Phosphorylation | Uniprot | |
| K1317 | Acetylation | Uniprot | |
| Y1321 | Phosphorylation | Uniprot | |
| S1323 | Phosphorylation | Uniprot | |
| S1327 | Phosphorylation | Uniprot | |
| K1332 | Acetylation | Uniprot | |
| Y1341 | Phosphorylation | Uniprot | |
| T1345 | Phosphorylation | Uniprot | |
| K1350 | Ubiquitination | Uniprot | |
| Y1382 | Phosphorylation | Uniprot |
研究背景
May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity).
Mitochondrion. Nucleus>Nucleoplasm. Nucleus inner membrane. Nucleus outer membrane.
Note: Seems to be predominantly mitochondrial.
Expressed ubiquitously. Expression is highest in heart, skeletal muscle, kidney and liver, intermediate in brain, non-mucosal colon, spleen and placenta, and lowest in small intestine, thymus, lung and peripheral blood leukocytes.
Interacts with CECR2, HEBP2, MAP1S and UXT. Interacts with PPARGC1A. Interacts with FOXO1 (By similarity). Component of mRNP complexes associated with HNRPA1.
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