p107 Antibody - #DF12438
| 製品: | p107 Antibody |
| カタログ: | DF12438 |
| タンパク質の説明: | Rabbit polyclonal antibody to p107 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus |
| 分子量: | 119 kDa; 121kD(Calculated). |
| ユニプロット: | P28749 |
| RRID: | AB_2845243 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12438, RRID:AB_2845243.
折りたたみ／展開
107 kDa retinoblastoma-associated protein; Cellular protein 107; Cellular protein p107; CP107; MGC40006; p107; PRB1; RBL1; RBL1_HUMAN; Retinoblastoma like protein 1; retinoblastoma-like 1 (p107); Retinoblastoma-like protein 1;
免疫原
- P28749 RBL1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MFEDKPHAEGAAVVAAAGEALQALCQELNLDEGSAAEALDDFTAIRGNYSLEGEVTHWLACSLYVACRKSIIPTVGKGIMEGNCVSLTRILRSAKLSLIQFFSKMKKWMDMSNLPQEFRERIERLERNFEVSTVIFKKYEPIFLDIFQNPYEEPPKLPRSRKQRRIPCSVKDLFNFCWTLFVYTKGNFRMIGDDLVNSYHLLLCCLDLIFANAIMCPNRQDLLNPSFKGLPSDFHTADFTASEEPPCIIAVLCELHDGLLVEAKGIKEHYFKPYISKLFDRKILKGECLLDLSSFTDNSKAVNKEYEEYVLTVGDFDERIFLGADAEEEIGTPRKFTRDTPLGKLTAQANVEYNLQQHFEKKRSFAPSTPLTGRRYLREKEAVITPVASATQSVSRLQSIVAGLKNAPSDQLINIFESCVRNPVENIMKILKGIGETFCQHYTQSTDEQPGSHIDFAVNRLKLAEILYYKILETVMVQETRRLHGMDMSVLLEQDIFHRSLMACCLEIVLFAYSSPRTFPWIIEVLNLQPFYFYKVIEVVIRSEEGLSRDMVKHLNSIEEQILESLAWSHDSALWEALQVSANKVPTCEEVIFPNNFETGNGGNVQGHLPLMPMSPLMHPRVKEVRTDSGSLRRDMQPLSPISVHERYSSPTAGSAKRRLFGEDPPKEMLMDKIITEGTKLKIAPSSSITAENVSILPGQTLLTMATAPVTGTTGHKVTIPLHGVANDAGEITLIPLSMNTNQESKVKSPVSLTAHSLIGASPKQTNLTKAQEVHSTGINRPKRTGSLALFYRKVYHLASVRLRDLCLKLDVSNELRRKIWTCFEFTLVHCPDLMKDRHLDQLLLCAFYIMAKVTKEERTFQEIMKSYRNQPQANSHVYRSVLLKSIPREVVAYNKNINDDFEMIDCDLEDATKTPDCSSGPVKEERGDLIKFYNTIYVGRVKSFALKYDLANQDHMMDAPPLSPFPHIKQQPGSPRRISQQHSIYISPHKNGSGLTPRSALLYKFNGSPSKSLKDINNMIRQGEQRTKKRVIAIDSDAESPAKRVCQENDDVLLKRLQDVVSERANH
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P28749 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T88 | Phosphorylation | Uniprot | |
| S93 | Phosphorylation | Uniprot | |
| S103 | Phosphorylation | Uniprot | |
| K300 | Ubiquitination | Uniprot | |
| K304 | Ubiquitination | Uniprot | |
| T332 | Phosphorylation | Uniprot | |
| T337 | Phosphorylation | Uniprot | |
| T340 | Phosphorylation | Uniprot | |
| S368 | Phosphorylation | Uniprot | |
| T369 | Phosphorylation | P11802 (CDK4) | Uniprot |
| T372 | Phosphorylation | Uniprot | |
| T385 | Phosphorylation | Uniprot | |
| S389 | Phosphorylation | Uniprot | |
| Y468 | Phosphorylation | Uniprot | |
| Y469 | Phosphorylation | Uniprot | |
| S615 | Phosphorylation | Uniprot | |
| S640 | Phosphorylation | P11802 (CDK4) , P24941 (CDK2) | Uniprot |
| S643 | Phosphorylation | Uniprot | |
| Y648 | Phosphorylation | Uniprot | |
| S650 | Phosphorylation | P24941 (CDK2) , P11802 (CDK4) | Uniprot |
| T652 | Phosphorylation | Uniprot | |
| K657 | Ubiquitination | Uniprot | |
| S749 | Phosphorylation | Uniprot | |
| S757 | Phosphorylation | Uniprot | |
| S762 | Phosphorylation | Uniprot | |
| T769 | Phosphorylation | Uniprot | |
| Y792 | Phosphorylation | Uniprot | |
| T915 | Phosphorylation | Uniprot | |
| S919 | Phosphorylation | Uniprot | |
| Y938 | Phosphorylation | Uniprot | |
| Y949 | Phosphorylation | Uniprot | |
| S964 | Phosphorylation | P11802 (CDK4) | Uniprot |
| S975 | Phosphorylation | P11802 (CDK4) | Uniprot |
| S980 | Phosphorylation | Uniprot | |
| S984 | Phosphorylation | Uniprot | |
| Y986 | Phosphorylation | Uniprot | |
| S988 | Phosphorylation | Uniprot | |
| S994 | Phosphorylation | Uniprot | |
| T997 | Phosphorylation | Uniprot | |
| S1000 | Phosphorylation | Uniprot | |
| Y1004 | Phosphorylation | Uniprot | |
| S1009 | Phosphorylation | Uniprot | |
| S1011 | Phosphorylation | Uniprot | |
| S1037 | Phosphorylation | Uniprot | |
| S1041 | Phosphorylation | Uniprot |
研究背景
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (By similarity). Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression (By similarity). Controls histone H4 'Lys-20' trimethylation (By similarity). Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (By similarity). Potent inhibitor of E2F-mediated trans-activation. May act as a tumor suppressor.
Cell-cycle arrest properties are inactivated by phosphorylation on Thr-332, Ser-640, Ser-964 and Ser-975 by CDK4.
Nucleus.
Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with AATF. Interacts with KDM5A. Interacts with KMT5B and KMT5C (By similarity). Interacts with USP4 (By similarity). Interacts with RBBP9 (By similarity).
(Microbial infection) Interacts with SV40 and JC virus large T antigens. Large T antigen, but not E1A, binds only to the unphosphorylated form.
Belongs to the retinoblastoma protein (RB) family.
研究領域
· Cellular Processes > Cell growth and death > Cell cycle. (View pathway)
· Cellular Processes > Cell growth and death > Cellular senescence. (View pathway)
· Environmental Information Processing > Signal transduction > TGF-beta signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.
· Human Diseases > Cancers: Overview > Viral carcinogenesis.
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