PARVB Antibody - #DF12443
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12443, RRID:AB_2845248.
折りたたみ／展開
Affixin; Beta parvin; Beta-parvin; CGI 56; CGI-56; Parvb; PARVB_HUMAN; parvin, beta;
免疫原
- Q9HBI1 PARVB_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSSAPRSPTPRPRRMKKDESFLGKLGGTLARKRRAREVSDLQEEGKNAINSPMSPALVDVHPEDTQLEENEERTMIDPTSKEDPKFKELVKVLLDWINDVLVEERIIVKQLEEDLYDGQVLQKLLEKLAGCKLNVAEVTQSEIGQKQKLQTVLEAVHDLLRPRGWALRWSVDSIHGKNLVAILHLLVSLAMHFRAPIRLPEHVTVQVVVVRKREGLLHSSHISEELTTTTEMMMGRFERDAFDTLFDHAPDKLSVVKKSLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEDYFVPLHHFYLTPESFDQKVHNVSFAFELMLDGGLKKPKARPEDVVNLDLKSTLRVLYNLFTKYKNVE
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9HBI1 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S3 | Phosphorylation | Uniprot | |
| S7 | Phosphorylation | Uniprot | |
| S20 | Phosphorylation | Uniprot | |
| K24 | Acetylation | Uniprot | |
| T28 | Phosphorylation | Uniprot | |
| S39 | Phosphorylation | Uniprot | |
| S54 | Phosphorylation | Uniprot | |
| T74 | Phosphorylation | Uniprot | |
| Y116 | Phosphorylation | Uniprot | |
| K123 | Ubiquitination | Uniprot | |
| K132 | Ubiquitination | Uniprot | |
| S170 | Phosphorylation | Uniprot | |
| T244 | Phosphorylation | Uniprot | |
| K252 | Ubiquitination | Uniprot | |
| Y354 | Phosphorylation | Uniprot | |
| Y360 | Phosphorylation | Uniprot |
研究背景
Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration.
Cell junction>Focal adhesion. Cell membrane>Peripheral membrane protein>Cytoplasmic side. Cytoplasm>Cytoskeleton. Cell projection>Lamellipodium. Cytoplasm>Myofibril>Sarcomere. Cytoplasm>Myofibril>Sarcomere>Z line.
Note: Constituent of focal adhesions. Detected at the tips of the leading edge of cells. Colocalizes with F-actin at the tips of lamellipodia.
Expressed predominantly in heart and skeletal muscle.
Interacts with DYSF. Interacts with ILK, ARHGEF6, PXN (via LD motifs), ACTN2 and actin.
Belongs to the parvin family.
研究領域
· Cellular Processes > Cellular community - eukaryotes > Focal adhesion. (View pathway)
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