PCMT1 Antibody - #DF12445
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12445, RRID:AB_2845250.
折りたたみ／展開
L isoaspartyl protein carboxyl methyltransferase; L isoaspartyl/D aspartyl methyltransferase; L-isoaspartyl protein carboxyl methyltransferase; PCMT 1; Pcmt1; PIMT; PIMT_HUMAN; Protein beta aspartate methyltransferase; Protein L isoaspartate (D aspartate) O methyltransferase; Protein L isoaspartyl/D aspartyl methyltransferase; Protein L-isoaspartyl/D-aspartyl methyltransferase; Protein-beta-aspartate methyltransferase; Protein-L-isoaspartate(D-aspartate) O-methyltransferase;
免疫原
- P22061 PIMT_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAWKSGGASHSELIHNLRKNGIIKTDKVFEVMLATDRSHYAKCNPYMDSPQSIGFQATISAPHMHAYALELLFDQLHEGAKALDVGSGSGILTACFARMVGCTGKVIGIDHIKELVDDSVNNVRKDDPTLLSSGRVQLVVGDGRMGYAEEAPYDAIHVGAAAPVVPQALIDQLKPGGRLILPVGPAGGNQMLEQYDKLQDGSIKMKPLMGVIYVPLTDKEKQWSRWK
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P22061 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| K4 | Ubiquitination | Uniprot | |
| R37 | Methylation | Uniprot | |
| S52 | Phosphorylation | Uniprot | |
| S89 | Phosphorylation | Uniprot | |
| K105 | Ubiquitination | Uniprot | |
| K113 | Ubiquitination | Uniprot | |
| R124 | Methylation | Uniprot | |
| K125 | Ubiquitination | Uniprot | |
| K174 | Ubiquitination | Uniprot | |
| K197 | Ubiquitination | Uniprot | |
| K206 | Ubiquitination | Uniprot | |
| Y213 | Phosphorylation | Uniprot |
研究背景
Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin carboxyl-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein.
Cytoplasm.
Monomer.
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
Restrictive clause
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For Research Use Only.
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