RAB14 Antibody - #DF12460
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12460, RRID:AB_2845265.
折りたたみ／展開
bA165P4.3; F protein binding protein 1; FBP; GTPase Rab14; RAB 14; RAB14; RAB14 member RAS oncogene family; RAB14_HUMAN; Ras related protein Rab 14; Ras-related protein Rab-14; RP11 165P4.4; Small GTP binding protein RAB14;
免疫原
- P61106 RAB14_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MATAPYNYSYIFKYIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVEFGTRIIEVSGQKIKLQIWDTAGQERFRAVTRSYYRGAAGALMVYDITRRSTYNHLSSWLTDARNLTNPNTVIILIGNKADLEAQRDVTYEEAKQFAEENGLLFLEASAKTGENVEDAFLEAAKKIYQNIQDGSLDLNAAESGVQHKPSAPQGGRLTSEPQPQREGCGC
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P61106 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| Y8 | Phosphorylation | Uniprot | |
| Y14 | Phosphorylation | Uniprot | |
| C26 | S-Nitrosylation | Uniprot | |
| K34 | Ubiquitination | Uniprot | |
| K35 | Ubiquitination | Uniprot | |
| S56 | Phosphorylation | Uniprot | |
| K59 | Ubiquitination | Uniprot | |
| K61 | Ubiquitination | Uniprot | |
| T67 | Phosphorylation | Uniprot | |
| Y80 | Phosphorylation | Uniprot | |
| Y81 | Phosphorylation | Uniprot | |
| Y91 | Phosphorylation | Uniprot | |
| S97 | Phosphorylation | Uniprot | |
| Y99 | Phosphorylation | Uniprot | |
| S103 | Phosphorylation | Uniprot | |
| T107 | Phosphorylation | Uniprot | |
| K125 | Ubiquitination | Uniprot | |
| K140 | Ubiquitination | Uniprot | |
| K156 | Ubiquitination | Uniprot | |
| K170 | Ubiquitination | Uniprot | |
| K171 | Ubiquitination | Uniprot | |
| S180 | Phosphorylation | Uniprot | |
| K193 | Ubiquitination | Uniprot |
研究背景
Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion.
Recycling endosome. Early endosome membrane>Lipid-anchor>Cytoplasmic side. Golgi apparatus membrane>Lipid-anchor>Cytoplasmic side. Golgi apparatus>trans-Golgi network membrane>Lipid-anchor>Cytoplasmic side. Cytoplasmic vesicle>Phagosome.
Note: Recruited to recycling endosomes by DENND6A (PubMed:22595670). Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211).
Interacts with KIF16B (By similarity). Interacts with ZFYVE20.
Belongs to the small GTPase superfamily. Rab family.
研究領域
· Environmental Information Processing > Signal transduction > AMPK signaling pathway. (View pathway)
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