Seladin 1 Antibody - #DF12472
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| 製品: | Seladin 1 Antibody |
| カタログ: | DF12472 |
| タンパク質の説明: | Rabbit polyclonal antibody to Seladin 1 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus |
| 分子量: | 60 kDa; 60kD(Calculated). |
| ユニプロット: | Q15392 |
| RRID: | AB_2845277 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12472, RRID:AB_2845277.
折りたたみ／展開
24 dehydrocholesterol reductase; 24-dehydrocholesterol reductase; 3 beta hydroxysterol delta 24 reductase; 3-beta-hydroxysterol delta-24-reductase; DCE; Delta(24)-sterol reductase; Desmosterol to cholesterol enzyme; DHC24_HUMAN; Dhcr24; Diminuto dwarf1 homolog; Diminuto/dwarf1 homolog; KIAA0018; Nbla03646; Seladin-1; SELADIN1; Selective AD indicator 1; Selective Alzheimer's Disease Indicator 1;
免疫原
Highly expressed in brain and adrenal gland with moderate expression in liver, lung, spleen, prostate and spinal cord. Low expression in heart, uterus and prostate. Undetectable in blood cells. In the brain, strongly expressed in cortical regions, substantia nigra, caudate nucleus, hippocampus, medulla oblongata and pons. In brains affected by Alzheimer disease, expression in the inferior temporal lobe is substantially lower than in the frontal cortex.
- Q15392 DHC24_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEPAVSLAVCALLFLLWVRLKGLEFVLIHQRWVFVCLFLLPLSLIFDIYYYVRAWVVFKLSSAPRLHEQRVRDIQKQVREWKEQGSKTFMCTGRPGWLTVSLRVGKYKKTHKNIMINLMDILEVDTKKQIVRVEPLVTMGQVTALLTSIGWTLPVLPELDDLTVGGLIMGTGIESSSHKYGLFQHICTAYELVLADGSFVRCTPSENSDLFYAVPWSCGTLGFLVAAEIRIIPAKKYVKLRFEPVRGLEAICAKFTHESQRQENHFVEGLLYSLDEAVIMTGVMTDEAEPSKLNSIGNYYKPWFFKHVENYLKTNREGLEYIPLRHYYHRHTRSIFWELQDIIPFGNNPIFRYLFGWMVPPKISLLKLTQGETLRKLYEQHHVVQDMLVPMKCLQQALHTFQNDIHVYPIWLCPFILPSQPGLVHPKGNEAELYIDIGAYGEPRVKHFEARSCMRQLEKFVRSVHGFQMLYADCYMNREEFWEMFDGSLYHKLREKLGCQDAFPEVYDKICKAARH
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q15392 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K76 | Ubiquitination | Uniprot | |
| K82 | Ubiquitination | Uniprot | |
| K87 | Ubiquitination | Uniprot | |
| T110 | Phosphorylation | Uniprot | |
| Y180 | Phosphorylation | Uniprot | |
| T188 | Phosphorylation | Uniprot | |
| Y190 | Phosphorylation | Uniprot | |
| S198 | Phosphorylation | Uniprot | |
| K254 | Ubiquitination | Uniprot | |
| Y299 | Phosphorylation | Uniprot | |
| Y300 | Phosphorylation | Uniprot | |
| K301 | Ubiquitination | Uniprot | |
| K313 | Methylation | Uniprot | |
| K313 | Ubiquitination | Uniprot | |
| Y321 | Phosphorylation | Uniprot | |
| K367 | Ubiquitination | Uniprot | |
| T373 | Phosphorylation | Uniprot | |
| K376 | Ubiquitination | Uniprot | |
| K427 | Ubiquitination | Uniprot | |
| K446 | Sumoylation | Uniprot | |
| K446 | Ubiquitination | Uniprot | |
| K459 | Ubiquitination | Uniprot | |
| K492 | Ubiquitination | Uniprot | |
| K496 | Ubiquitination | Uniprot | |
| Y507 | Phosphorylation | Uniprot | |
| K509 | Ubiquitination | Uniprot | |
| K512 | Ubiquitination | Uniprot |
研究背景
Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. In addition to its cholesterol-synthesizing activity, can protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis.
Endoplasmic reticulum membrane>Single-pass membrane protein. Golgi apparatus membrane>Single-pass membrane protein.
Highly expressed in brain and adrenal gland with moderate expression in liver, lung, spleen, prostate and spinal cord. Low expression in heart, uterus and prostate. Undetectable in blood cells. In the brain, strongly expressed in cortical regions, substantia nigra, caudate nucleus, hippocampus, medulla oblongata and pons. In brains affected by Alzheimer disease, expression in the inferior temporal lobe is substantially lower than in the frontal cortex.
Interacts with DHCR7; this interaction regulates DHCR7 activity.
Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
研究領域
· Metabolism > Lipid metabolism > Steroid biosynthesis.
· Metabolism > Global and overview maps > Metabolic pathways.
参考文献
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