ZFYVE16 Antibody - #DF12507
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12507, RRID:AB_2845312.
折りたたみ/展開
AI035632; B130024H06Rik; B130031L15; DKFZp686E13162; Endofin; Endosomal associated FYVE domain protein; Endosome associated FYVE domain protein; Endosome-associated FYVE domain protein; KIAA0305; KIAA0305;; mKIAA0305; OTTMUSP00000029589; RGD1564784; ZFY16_HUMAN; ZFYVE16; Zinc finger FYVE domain containing protein 16; Zinc finger FYVE domain-containing protein 16; Zinc finger, FYVE domain containing 16;
免疫原
Widely expressed. Highly expressed in kidney, placenta and lung. Expressed at intermediate level in heart, brain, skeletal muscle, spleen and liver. Weakly expressed in colon, thymus and peripheral blood lymphocytes.
- Q7Z3T8 ZFY16_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDSYFKAAVSDLDKLLDDFEQNPDEQDYLQDVQNAYDSNHCSVSSELASSQRTSLLPKDQECVNSCASSETSYGTNESSLNEKTLKGLTSIQNEKNVTGLDLLSSVDGGTSDEIQPLYMGRCSKPICDLISDMGNLVHATNSEEDIKKLLPDDFKSNADSLIGLDLSSVSDTPCVSSTDHDSDTVREQQNDISSELQNREIGGIKELGIKVDTTLSDSYNYSGTENLKDKKIFNQLESIVDFNMSSALTRQSSKMFHAKDKLQHKSQPCGLLKDVGLVKEEVDVAVITAAECLKEEGKTSALTCSLPKNEDLCLNDSNSRDENFKLPDFSFQEDKTVIKQSAQEDSKSLDLKDNDVIQDSSSALHVSSKDVPSSLSCLPASGSMCGSLIESKARGDFLPQHEHKDNIQDAVTIHEEIQNSVVLGGEPFKENDLLKQEKCKSILLQSLIEGMEDRKIDPDQTVIRAESLDGGDTSSTVVESQEGLSGTHVPESSDCCEGFINTFSSNDMDGQDLDYFNIDEGAKSGPLISDAELDAFLTEQYLQTTNIKSFEENVNDSKSQMNQIDMKGLDDGNINNIYFNAEAGAIGESHGINIICEIVDKQNTIENGLSLGEKSTIPVQQGLPTSKSEITNQLSVSDINSQSVGGARPKQLFSLPSRTRSSKDLNKPDVPDTIESEPSTADTVVPITCAIDSTADPQVSFNSNYIDIESNSEGGSSFVTANEDSVPENTCKEGLVLGQKQPTWVPDSEAPNCMNCQVKFTFTKRRHHCRACGKVFCGVCCNRKCKLQYLEKEARVCVVCYETISKAQAFERMMSPTGSNLKSNHSDECTTVQPPQENQTSSIPSPATLPVSALKQPGVEGLCSKEQKRVWFADGILPNGEVADTTKLSSGSKRCSEDFSPLSPDVPMTVNTVDHSHSTTVEKPNNETGDITRNEIIQSPISQVPSVEKLSMNTGNEGLPTSGSFTLDDDVFAETEEPSSPTGVLVNSNLPIASISDYRLLCDINKYVCNKISLLPNDEDSLPPLLVASGEKGSVPVVEEHPSHEQIILLLEGESFHPVTFVLNANLLVNVKFIFYSSDKYWYFSTNGLHGLGQAEIIILLLCLPNEDTIPKDIFRLFITIYKDALKGKYIENLDNITFTESFLSSKDHGGFLFITPTFQKLDDLSLPSNPFLCGILIQKLEIPWAKVFPMRLMLRLGAEYKAYPAPLTSIRGRKPLFGEIGHTIMNLLVDLRNYQYTLHNIDQLLIHMEMGKSCIKIPRKKYSDVMKVLNSSNEHVISIGASFSTEADSHLVCIQNDGIYETQANSATGHPRKVTGASFVVFNGALKTSSGFLAKSSIVEDGLMVQITPETMNGLRLALREQKDFKITCGKVDAVDLREYVDICWVDAEEKGNKGVISSVDGISLQGFPSEKIKLEADFETDEKIVKCTEVFYFLKDQDLSILSTSYQFAKEIAMACSAALCPHLKTLKSNGMNKIGLRVSIDTDMVEFQAGSEGQLLPQHYLNDLDSALIPVIHGGTSNSSLPLEIELVFFIIEHLF
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q7Z3T8 基板として
Site | PTM Type | Enzyme | Source |
---|---|---|---|
S10 | Phosphorylation | Uniprot | |
Y28 | Phosphorylation | Uniprot | |
Y36 | Phosphorylation | Uniprot | |
Y73 | Phosphorylation | Uniprot | |
K86 | Ubiquitination | Uniprot | |
T89 | Phosphorylation | Uniprot | |
S90 | Phosphorylation | Uniprot | |
K95 | Ubiquitination | Uniprot | |
Y118 | Phosphorylation | Uniprot | |
K124 | Ubiquitination | Uniprot | |
T140 | Phosphorylation | Uniprot | |
S142 | Phosphorylation | Uniprot | |
K148 | Ubiquitination | Uniprot | |
S160 | Phosphorylation | Uniprot | |
S167 | Phosphorylation | Uniprot | |
S168 | Phosphorylation | Uniprot | |
S170 | Phosphorylation | Uniprot | |
K205 | Ubiquitination | Uniprot | |
S216 | Phosphorylation | Uniprot | |
S218 | Phosphorylation | Uniprot | |
Y219 | Phosphorylation | Uniprot | |
Y221 | Phosphorylation | Uniprot | |
K228 | Acetylation | Uniprot | |
K228 | Ubiquitination | Uniprot | |
S253 | Phosphorylation | Uniprot | |
K265 | Ubiquitination | Uniprot | |
S305 | Phosphorylation | Uniprot | |
S317 | Phosphorylation | Uniprot | |
S319 | Phosphorylation | Uniprot | |
K325 | Ubiquitination | Uniprot | |
S330 | Phosphorylation | Uniprot | |
K335 | Ubiquitination | Uniprot | |
S348 | Phosphorylation | Uniprot | |
S367 | Phosphorylation | Uniprot | |
S376 | Phosphorylation | Uniprot | |
S391 | Phosphorylation | Uniprot | |
K392 | Ubiquitination | Uniprot | |
S441 | Phosphorylation | Uniprot | |
S446 | Phosphorylation | Uniprot | |
K455 | Ubiquitination | Uniprot | |
Y515 | Phosphorylation | Uniprot | |
S529 | Phosphorylation | Uniprot | |
Y541 | Phosphorylation | Uniprot | |
K548 | Ubiquitination | Uniprot | |
S549 | Phosphorylation | Uniprot | |
S557 | Phosphorylation | Uniprot | |
K558 | Ubiquitination | Uniprot | |
Y578 | Phosphorylation | Uniprot | |
K614 | Ubiquitination | Uniprot | |
T616 | Phosphorylation | Uniprot | |
K627 | Ubiquitination | Uniprot | |
S635 | Phosphorylation | Uniprot | |
S643 | Phosphorylation | Uniprot | |
K650 | Ubiquitination | Uniprot | |
S654 | Phosphorylation | Uniprot | |
S661 | Phosphorylation | Uniprot | |
K740 | Ubiquitination | Uniprot | |
Y789 | Phosphorylation | Uniprot | |
S815 | Phosphorylation | Uniprot | |
S845 | Phosphorylation | Uniprot | |
T848 | Phosphorylation | Uniprot | |
K855 | Ubiquitination | Uniprot | |
K865 | Ubiquitination | Uniprot | |
S896 | Phosphorylation | Uniprot | |
S903 | Phosphorylation | Uniprot | |
T928 | Phosphorylation | Uniprot | |
T932 | Phosphorylation | Uniprot | |
S939 | Phosphorylation | Uniprot | |
S942 | Phosphorylation | Uniprot | |
S946 | Phosphorylation | Uniprot | |
K1006 | Ubiquitination | Uniprot | |
K1011 | Ubiquitination | Uniprot | |
S1029 | Phosphorylation | Uniprot | |
T1120 | Phosphorylation | Uniprot | |
K1147 | Ubiquitination | Uniprot | |
T1156 | Phosphorylation | Uniprot | |
Y1201 | Phosphorylation | Uniprot | |
K1202 | Ubiquitination | Uniprot | |
Y1204 | Phosphorylation | Uniprot | |
T1209 | Phosphorylation | Uniprot | |
S1210 | Phosphorylation | Uniprot | |
K1257 | Ubiquitination | Uniprot | |
K1336 | Ubiquitination | Uniprot | |
S1337 | Phosphorylation | Uniprot | |
K1364 | Ubiquitination | Uniprot | |
K1367 | Ubiquitination | Uniprot | |
K1372 | Ubiquitination | Uniprot | |
Y1381 | Phosphorylation | Uniprot | |
K1392 | Ubiquitination | Uniprot | |
K1395 | Ubiquitination | Uniprot | |
K1413 | Ubiquitination | Uniprot | |
K1452 | Acetylation | Uniprot |
研究背景
May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes.
Cytoplasm. Early endosome membrane>Peripheral membrane protein.
Note: Localized to early endosomes. Membrane-associated, probably via its association with phosphatidylinositol 3-phosphate (PI3P).
Widely expressed. Highly expressed in kidney, placenta and lung. Expressed at intermediate level in heart, brain, skeletal muscle, spleen and liver. Weakly expressed in colon, thymus and peripheral blood lymphocytes.
Interacts with the C-terminus of TOM1. Does not interact with TOM1L1 or TOM1L2.
The FYVE-type zinc finger is necessary and sufficient for its localization into early endosomes and mediates the association with PI3P.
研究領域
· Cellular Processes > Transport and catabolism > Endocytosis. (View pathway)
· Environmental Information Processing > Signal transduction > TGF-beta signaling pathway. (View pathway)
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