Phospho-PSD93 (Tyr340) Antibody - #AF2389
| 製品: | Phospho-PSD93 (Tyr340) Antibody |
| カタログ: | AF2389 |
| タンパク質の説明: | Rabbit polyclonal antibody to Phospho-PSD93 (Tyr340) |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Rabbit, Dog |
| 分子量: | 110kDa; 98kD(Calculated). |
| ユニプロット: | Q15700 |
| RRID: | AB_2845403 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF2389, RRID:AB_2845403.
折りたたみ／展開
Channel associated protein of synapse 110; Channel associated protein of synapses 110kD; Channel-associated protein of synapse-110; Chapsyn 110; Chapsyn-110; Chapsyn110; Discs, large homolog 2 (Drosophila); Disks large homolog 2; DKFZp781D1854; DKFZp781E0954; Dlg 2; dlg2; DLG2_HUMAN; Dlgh 2; Dlgh2; FLJ37266; Gm1197; MGC131811; Postsynaptic density protein PSD 93; Postsynaptic density protein PSD-93; Postsynaptic density protein PSD93; PSD 93; PSD93;
免疫原
- Q15700 DLG2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MFFACYCALRTNVKKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q15700 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S28 | Phosphorylation | Uniprot | |
| S175 | Phosphorylation | Uniprot | |
| Y180 | Phosphorylation | Uniprot | |
| T225 | Phosphorylation | Uniprot | |
| T257 | Phosphorylation | Uniprot | |
| T317 | Phosphorylation | Uniprot | |
| S318 | Phosphorylation | Uniprot | |
| S323 | Phosphorylation | P28482 (MAPK1) | Uniprot |
| Y327 | Phosphorylation | Uniprot | |
| Y340 | Phosphorylation | Uniprot | |
| Y348 | Phosphorylation | Uniprot | |
| S365 | Phosphorylation | Uniprot | |
| S414 | Phosphorylation | Uniprot | |
| K511 | Ubiquitination | Uniprot | |
| S523 | Phosphorylation | Uniprot | |
| S530 | Phosphorylation | Uniprot | |
| S553 | Phosphorylation | Uniprot | |
| S598 | Phosphorylation | Uniprot | |
| S627 | Phosphorylation | Uniprot | |
| S635 | Phosphorylation | Uniprot | |
| K690 | Ubiquitination | Uniprot | |
| Y719 | Phosphorylation | Uniprot | |
| Y726 | Phosphorylation | Uniprot |
研究背景
Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity).
Palmitoylation of isoform 1 is not required for targeting to postsynaptic density.
Cell membrane>Lipid-anchor. Cell junction>Synapse>Postsynaptic density. Cell junction>Synapse. Membrane. Cell projection>Axon. Perikaryon.
Note: Concentrated in soma and postsynaptic density of a subset of neurons.
Interacts through its PDZ domains with NETO1 (By similarity). Interacts with NOS1/nNOS through second PDZ domain (By similarity). Interacts with KCNJ2/Kir2.1 (via C-terminus) through one of its PDZ domains. Interacts with KCNJ4 (By similarity), Interacts with FRMPD4 (via C-terminus). Interacts with LRFN1, LRFN2 and LRFN4. Interacts with FASLG. Interacts with KCNJ4 (By similarity). Interacts with ADAM22 (By similarity).
An N-terminally truncated L27 domain is predicted in isoform 2 at positions 1 through 27.
Belongs to the MAGUK family.
研究領域
· Cellular Processes > Cellular community - eukaryotes > Tight junction. (View pathway)
· Environmental Information Processing > Signal transduction > Hippo signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.