Phospho-TNK1 (Tyr277) Antibody - #AF2426
| 製品: | Phospho-TNK1 (Tyr277) Antibody |
| カタログ: | AF2426 |
| タンパク質の説明: | Rabbit polyclonal antibody to Phospho-TNK1 (Tyr277) |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Rabbit, Dog |
| 分子量: | 72kDa; 72kD(Calculated). |
| ユニプロット: | Q13470 |
| RRID: | AB_2845439 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF2426, RRID:AB_2845439.
折りたたみ／展開
CD38 negative kinase 1; EC 2.7.10.2; Kinase of embryonic stem cells; Kos 1; Kos1; MGC46193; Non receptor tyrosine protein kinase TNK 1; Non receptor tyrosine protein kinase TNK1; Non-receptor tyrosine-protein kinase TNK1; Tnk 1; Tnk1; TNK1_HUMAN; Tyrosine kinase non receptor 1;
免疫原
Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in adult prostate, testis, ovary, small intestine and colon. Not expressed in adult lung, liver, kidney or brain.
- Q13470 TNK1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLPEAGSLWLLKLLRDIQLAQFYWPILEELNVTRPEHFDFVKPEDLDGIGMGRPAQRRLSEALKRLRSGPKSKNWVYKILGGFAPEHKEPTLPSDSPRHLPEPEGGLKCLIPEGAVCRGELLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHVLRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALRCWAPHPADRPSFSHLEGLLQEAGPSEACCVRDVTEPGALRMETGDPITVIEGSSSFHSPDSTIWKGQNGRTFKVGSFPASAVTLADAGGLPATRPVHRGTPARGDQHPGSIDGDRKKANLWDAPPARGQRRNMPLERMKGISRSLESVLSLGPRPTGGGSSPPEIRQARAVPQGPPGLPPRPPLSSSSPQPSQPSRERLPWPKRKPPHNHPMGMPGARKAAALSGGLLSDPELQRKIMEVELSVHGVTHQECQTALGATGGDVVSAIRNLKVDQLFHLSSRSRADCWRILEHYQWDLSAASRYVLARP
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q13470 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S60 | Phosphorylation | Uniprot | |
| S68 | Phosphorylation | Uniprot | |
| K73 | Ubiquitination | Uniprot | |
| Y77 | Phosphorylation | Uniprot | |
| K88 | Ubiquitination | Uniprot | |
| S94 | Phosphorylation | Uniprot | |
| S96 | Phosphorylation | Uniprot | |
| K108 | Ubiquitination | Uniprot | |
| S139 | Phosphorylation | Uniprot | |
| K141 | Ubiquitination | Uniprot | |
| T209 | Phosphorylation | Uniprot | |
| T214 | Phosphorylation | Uniprot | |
| Y235 | Phosphorylation | Uniprot | |
| T248 | Phosphorylation | Uniprot | |
| S255 | Phosphorylation | Uniprot | |
| T258 | Phosphorylation | Uniprot | |
| K260 | Ubiquitination | Uniprot | |
| Y277 | Phosphorylation | Uniprot | |
| Y287 | Phosphorylation | Uniprot | |
| Y353 | Phosphorylation | Uniprot | |
| S354 | Phosphorylation | Uniprot | |
| S468 | Phosphorylation | Uniprot | |
| K475 | Methylation | Uniprot | |
| S500 | Phosphorylation | Uniprot | |
| S502 | Phosphorylation | O14757 (CHEK1) | Uniprot |
| S505 | Phosphorylation | Uniprot | |
| S508 | Phosphorylation | Uniprot | |
| T514 | Phosphorylation | Uniprot | |
| S518 | Phosphorylation | Uniprot | |
| S519 | Phosphorylation | Uniprot | |
| S546 | Phosphorylation | Uniprot | |
| S550 | Phosphorylation | Uniprot | |
| S553 | Phosphorylation | Uniprot | |
| K563 | Ubiquitination | Uniprot | |
| K577 | Ubiquitination | Uniprot | |
| S582 | Phosphorylation | Uniprot | |
| S587 | Phosphorylation | Uniprot | |
| T612 | Phosphorylation | Uniprot | |
| Y651 | Phosphorylation | Uniprot | |
| S659 | Phosphorylation | Uniprot | |
| Y661 | Phosphorylation | Uniprot |
研究背景
Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction.
Autophosphorylated on tyrosine residues.
Cytoplasm. Membrane>Peripheral membrane protein.
Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in adult prostate, testis, ovary, small intestine and colon. Not expressed in adult lung, liver, kidney or brain.
Interacts with the SH3 domain of PLCG1 via its Pro-rich domain.
Belongs to the protein kinase superfamily. Tyr protein kinase family.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.