Phospho-Dynamin 1 (Ser774) Antibody - #AF3396
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF3396, RRID:AB_2834827.
折りたたみ／展開
B dynamin; D100; DNM 1; DNM; DNM1; DYN1_HUMAN; Dynamin; Dynamin-1; Dynamin1;
免疫原
- Q05193 DYN1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGNRGMEDLIPLVNRLQDAFSAIGQNADLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLVLQLVNATTEYAEFLHCKGKKFTDFEEVRLEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQIRDMLMQFVTKENCLILAVSPANSDLANSDALKVAKEVDPQGQRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIDGKKDITAALAAERKFFLSHPSYRHLADRMGTPYLQKVLNQQLTNHIRDTLPGLRNKLQSQLLSIEKEVEEYKNFRPDDPARKTKALLQMVQQFAVDFEKRIEGSGDQIDTYELSGGARINRIFHERFPFELVKMEFDEKELRREISYAIKNIHGIRTGLFTPDMAFETIVKKQVKKIREPCLKCVDMVISELISTVRQCTKKLQQYPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNKKKTSGNQDEILVIRKGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDYRQLELACETQEEVDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTKEFIFSELLANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPTPQRRAPAVPPARPGSRGPAPGPPPAGSALGGAPPVPSRPGASPDPFGPPPQVPSRPNRAPPGVPSRSGQASPSRPESPRPPFDL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q05193 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S46 | Phosphorylation | Uniprot | |
| S61 | Phosphorylation | Uniprot | |
| K113 | Ubiquitination | Uniprot | |
| S116 | Phosphorylation | Uniprot | |
| K206 | Ubiquitination | Uniprot | |
| T214 | Phosphorylation | Uniprot | |
| R217 | Methylation | Uniprot | |
| K223 | Ubiquitination | Uniprot | |
| Y231 | Phosphorylation | P12931 (SRC) | Uniprot |
| K257 | Ubiquitination | Uniprot | |
| S261 | Phosphorylation | Uniprot | |
| S264 | Phosphorylation | Uniprot | |
| R271 | Methylation | Uniprot | |
| S302 | Phosphorylation | Uniprot | |
| S306 | Phosphorylation | Uniprot | |
| S347 | Phosphorylation | Uniprot | |
| Y354 | Phosphorylation | Uniprot | |
| K376 | Ubiquitination | Uniprot | |
| T411 | Phosphorylation | Uniprot | |
| S433 | Phosphorylation | Uniprot | |
| S437 | Phosphorylation | Uniprot | |
| T438 | Phosphorylation | Uniprot | |
| T443 | Phosphorylation | Uniprot | |
| S512 | Phosphorylation | Uniprot | |
| K523 | Ubiquitination | Uniprot | |
| K598 | Acetylation | Uniprot | |
| S668 | Phosphorylation | Uniprot | |
| Y669 | Phosphorylation | Uniprot | |
| Y732 | Phosphorylation | Uniprot | |
| S774 | Phosphorylation | Uniprot | |
| T776 | Phosphorylation | Uniprot | |
| S777 | Phosphorylation | Uniprot | |
| S778 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| T780 | Phosphorylation | Q00535 (CDK5) | Uniprot |
| S795 | Phosphorylation | Q13627 (DYRK1A) | Uniprot |
| S822 | Phosphorylation | Uniprot | |
| S851 | Phosphorylation | Uniprot | |
| S857 | Phosphorylation | Q13627 (DYRK1A) | Uniprot |
研究背景
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.
Cytoplasm. Cytoplasm>Cytoskeleton.
Note: Microtubule-associated.
Interacts with CAV1 and SH3GLB1. Binds SH3GL1, SH3GL2 and SH3GL3 (By similarity). Interacts with PHOCN. Interacts with PACSIN1, PACSIN2 and PACSIN3 (By similarity). Interacts with SNX9. Interacts with MYO1E (via SH3 domain). Interacts with SNX33 (via SH3 domain). Interacts with UNC119; leading to a decrease of DNM1 GTPase activity (By similarity). Interacts with DIAPH1. Interacts with AMPH, BIN1 AND SYNJ1 (By similarity).
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
研究領域
· Cellular Processes > Transport and catabolism > Endocytosis. (View pathway)
· Environmental Information Processing > Signal transduction > Phospholipase D signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Bacterial > Bacterial invasion of epithelial cells.
· Organismal Systems > Nervous system > Synaptic vesicle cycle.
· Organismal Systems > Excretory system > Endocrine and other factor-regulated calcium reabsorption.
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