ARPC2 Antibody - #DF12561
| 製品: | ARPC2 Antibody |
| カタログ: | DF12561 |
| タンパク質の説明: | Rabbit polyclonal antibody to ARPC2 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Zebrafish, Bovine, Horse, Rabbit, Dog, Chicken |
| 分子量: | 34 kDa; 34kD(Calculated). |
| ユニプロット: | O15144 |
| RRID: | AB_2845523 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12561, RRID:AB_2845523.
折りたたみ／展開
Actin related protein 2/3 complex subunit 2 34kDa; Actin related protein 2/3 complex subunit 2; Actin-related protein 2/3 complex subunit 2; ARC 34; ARC34; Arp2/3 complex 34 kDa subunit; ARP2/3 protein compex subunit 34; ARPC 2; Arpc2; ARPC2_HUMAN; p34 Arc; p34-ARC; p34Arc; PNAS 139; PNAS139; PRO 2446; PRO2446;
免疫原
- O15144 ARPC2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MILLEVNNRIIEETLALKFENAAAGNKPEAVEVTFADFDGVLYHISNPNGDKTKVMVSISLKFYKELQAHGADELLKRVYGSFLVNPESGYNVSLLYDLENLPASKDSIVHQAGMLKRNCFASVFEKYFQFQEEGKEGENRAVIHYRDDETMYVESKKDRVTVVFSTVFKDDDDVVIGKVFMQEFKEGRRASHTAPQVLFSHREPPLELKDTDAAVGDNIGYITFVLFPRHTNASARDNTINLIHTFRDYLHYHIKCSKAYIHTRMRAKTSDFLKVLNRARPDAEKKEMKTITGKTFSSR
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O15144 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K27 | Ubiquitination | Uniprot | |
| K65 | Ubiquitination | Uniprot | |
| K77 | Ubiquitination | Uniprot | |
| S108 | Phosphorylation | Uniprot | |
| K117 | Ubiquitination | Uniprot | |
| S123 | Phosphorylation | Uniprot | |
| K127 | Acetylation | Uniprot | |
| K127 | Ubiquitination | Uniprot | |
| K136 | Ubiquitination | Uniprot | |
| T151 | Phosphorylation | Uniprot | |
| Y153 | Phosphorylation | Uniprot | |
| S156 | Phosphorylation | Uniprot | |
| K157 | Ubiquitination | Uniprot | |
| K179 | Ubiquitination | Uniprot | |
| K186 | Acetylation | Uniprot | |
| K186 | Ubiquitination | Uniprot | |
| T194 | Phosphorylation | Uniprot | |
| K210 | Ubiquitination | Uniprot | |
| T240 | Phosphorylation | Uniprot | |
| Y250 | Phosphorylation | Uniprot | |
| Y253 | Phosphorylation | Uniprot | |
| K256 | Ubiquitination | Uniprot | |
| Y261 | Phosphorylation | Uniprot | |
| K269 | Ubiquitination | Uniprot | |
| K275 | Acetylation | Uniprot | |
| K275 | Ubiquitination | Uniprot | |
| K290 | Ubiquitination | Uniprot | |
| K295 | Acetylation | Uniprot | |
| K295 | Methylation | Uniprot | |
| K295 | Ubiquitination | Uniprot | |
| T296 | Phosphorylation | Uniprot |
研究背景
Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the mother actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
Cytoplasm>Cytoskeleton. Cell projection. Cell junction>Synapse>Synaptosome. Nucleus.
Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex (By similarity).
Belongs to the ARPC2 family.
研究領域
· Cellular Processes > Transport and catabolism > Endocytosis. (View pathway)
· Cellular Processes > Cell motility > Regulation of actin cytoskeleton. (View pathway)
· Human Diseases > Infectious diseases: Bacterial > Bacterial invasion of epithelial cells.
· Human Diseases > Infectious diseases: Bacterial > Pathogenic Escherichia coli infection.
· Human Diseases > Infectious diseases: Bacterial > Shigellosis.
· Human Diseases > Infectious diseases: Bacterial > Salmonella infection.
· Organismal Systems > Immune system > Fc gamma R-mediated phagocytosis. (View pathway)
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