CPLX3 Antibody - #DF12587
| 製品: | CPLX3 Antibody |
| カタログ: | DF12587 |
| タンパク質の説明: | Rabbit polyclonal antibody to CPLX3 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Dog |
| 分子量: | 22 kDa; 18kD(Calculated). |
| ユニプロット: | Q8WVH0 |
| RRID: | AB_2845549 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12587, RRID:AB_2845549.
折りたたみ／展開
Complexin 3; Complexin III; Complexin-3; CPLX3; CPLX3_HUMAN; CPX III; CPX-III; CPXIII; ERGIC 53L; ERGL; FLJ13993; Lamn1l; Nbla11589;
免疫原
- Q8WVH0 CPLX3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAFMVKTMVGGQLKNLTGSLGGGEDKGDGDKSAAEAQGMSREEYEEYQKQLVEEKMERDAQFTQRKAERATLRSHFRDKYRLPKNETDESQIQMAGGDVELPRELAKMIEEDTEEEEEKASVLGQLASLPGLNLGSLKDKAQATLGDLKQSAEKCHVM
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
研究背景
Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (By similarity). Required for the maintenance of synaptic ultrastructure in the adult retina (By similarity). Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (By similarity). Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca(2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca(2+) vesicle release (By similarity).
Farnesylation mediates presynaptic targeting.
Cell junction>Synapse. Cell membrane>Lipid-anchor.
Note: Enriched at the synaptic terminal (By similarity). Localized at glycinergic synaptic contacts of AII amacrine cells with OFF cone bipolar cells in the OFF sublamina of the retina inner nuclear layer (By similarity).
Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.
Belongs to the complexin/synaphin family.
研究領域
· Organismal Systems > Nervous system > Synaptic vesicle cycle.
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