FLCN Antibody - #DF12608
| 製品: | FLCN Antibody |
| カタログ: | DF12608 |
| タンパク質の説明: | Rabbit polyclonal antibody to FLCN |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse, Rat, Monkey |
| 予測: | Pig, Bovine, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 45 kDa,70kDa; 64kD(Calculated). |
| ユニプロット: | Q8NFG4 |
| RRID: | AB_2845570 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12608, RRID:AB_2845570.
折りたたみ／展開
BHD; BHD skin lesion fibrofolliculoma protein; Birt Hogg Dube syndrome protein; Birt-Hogg-Dube syndrome protein; DKFZp547A118; FLCL; Flcn; FLCN_HUMAN; FLJ45004; FLJ99377; Folliculin; MGC17998; MGC23445;
免疫原
Expressed in most tissues tested, including skin, lung, kidney, heart, testis and stomach.
- Q8NFG4 FLCN_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNAIVALCHFCELHGPRTLFCTEVLHAPLPQGDGNEDSPGQGEQAEEEEGGIQMNSRMRAHSPAEGASVESSSPGPKKSDMCEGCRSLAAGHPGYISHDKETSIKYVSHQHPSHPQLFSIVRQACVRSLSCEVCPGREGPIFFGDEQHGFVFSHTFFIKDSLARGFQRWYSIITIMMDRIYLINSWPFLLGKVRGIIDELQGKALKVFEAEQFGCPQRAQRMNTAFTPFLHQRNGNAARSLTSLTSDDNLWACLHTSFAWLLKACGSRLTEKLLEGAPTEDTLVQMEKLADLEEESESWDNSEAEEEEKAPVLPESTEGRELTQGPAESSSLSGCGSWQPRKLPVFKSLRHMRQVLGAPSFRMLAWHVLMGNQVIWKSRDVDLVQSAFEVLRTMLPVGCVRIIPYSSQYEEAYRCNFLGLSPHVQIPPHVLSSEFAVIVEVHAAARSTLHPVGCEDDQSLSKYEFVVTSGSPVAADRVGPTILNKIEAALTNQNLSVDVVDQCLVCLKEEWMNKVKVLFKFTKVDSRPKEDTQKLLSILGASEEDNVKLLKFWMTGLSKTYKSHLMSTVRSPTASESRN
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q8NFG4 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S62 | Phosphorylation | P54646 (PRKAA2) | Uniprot |
| S68 | Phosphorylation | Uniprot | |
| S71 | Phosphorylation | Uniprot | |
| S72 | Phosphorylation | Uniprot | |
| S73 | Phosphorylation | Uniprot | |
| K100 | Ubiquitination | Uniprot | |
| K203 | Ubiquitination | Uniprot | |
| K206 | Ubiquitination | Uniprot | |
| T224 | Phosphorylation | Uniprot | |
| K272 | Ubiquitination | Uniprot | |
| S298 | Phosphorylation | Uniprot | |
| S302 | Phosphorylation | Uniprot | |
| S406 | Phosphorylation | Uniprot | |
| R477 | Methylation | Uniprot | |
| K534 | Ubiquitination | Uniprot | |
| S537 | Phosphorylation | Uniprot | |
| S542 | Phosphorylation | Uniprot | |
| S558 | Phosphorylation | Uniprot | |
| K559 | Ubiquitination | Uniprot | |
| K562 | Ubiquitination | Uniprot | |
| S571 | Phosphorylation | Uniprot |
研究背景
May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1.
Phosphorylated. Several different phosphorylated forms exist.
Cytoplasm. Nucleus.
Note: Mainly localized in the nucleus. Colocalizes with FNIP1 and FNIP2 in the cytoplasm.
Expressed in most tissues tested, including skin, lung, kidney, heart, testis and stomach.
Interacts (via C-terminus) with FNIP1 and FNIP2 (via C-terminus). This mediates indirect interaction with the PRKAA1, PRKAB1 and PRKAG1 subunits of 5'-AMP-activated protein kinase. Interacts with HSP90AA1 in the presence of FNIP1. Interacts with HSP70, STUB1, CDC37, AHSA1, CCT2, STIP1, PTGES3 and PPP5C.
Belongs to the folliculin family.
研究領域
· Environmental Information Processing > Signal transduction > mTOR signaling pathway. (View pathway)
· Human Diseases > Cancers: Specific types > Renal cell carcinoma. (View pathway)
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